Environmental enrichment and a selective metabotropic glutamate receptor2/3 (mGluR2/3) agonist suppress amphetamine self-administration: Characterizing baseline differences

Garcia, Erik J.; Cain, Mary E.

doi:10.1016/j.pbb.2020.172907

Cited by 7 publications

(7 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lever press training, AMP self‐administration and AMP‐seeking tests were conducted in standard operant conditioning chambers (ENV‐001, Med Associates, St. Albans, VT, USA) enclosed in a sound‐attenuating and ventilated cubicle. AMP or SAL infusions were administered via a syringe pump (PHM‐100, Med Associates) connected to a 10‐ml syringe (Arndt, Garcia, et al, 2015;Arndt, Johns, et al, 2015; Garcia et al, 2019; Garcia & Cain, 2020).…”

Section: Methodsmentioning

confidence: 99%

“…Rats were trained to self‐administered AMP (0.1 mg/kg/infusion) or SAL (equal volume to AMP) on an FR‐1 schedule of reinforcement in daily 1‐h sessions. Active lever presses infused AMP or SAL over ~5.9 s. Infusions of AMP and SAL were paired with the illumination of the white cue light above the active lever for 5.9 s and pump infusion sound (Arndt et al, 2019; Arndt, Johns, et al, 2015; Garcia et al, 2019; Garcia & Cain, 2020). After infusions, the cue light and infusion pump then turned off, and the house light remained on to signal a 20‐s timeout.…”

Section: Methodsmentioning

confidence: 99%

“…Rats were anesthetized with ketamine (80 mg/kg, ip) and diazepam (5 mg/kg, ip) (Arndt, Johns, et al, 2015; Garcia et al, 2019; Garcia & Cain, 2020). Polyurethane catheters (12‐cm length, 0.2‐mm internal diameter; SAI Infusion Technologies) were implanted into the left jugular vein.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Isolation housing elevates amphetamine seeking independent of nucleus accumbens glutamate receptor adaptations

Garcia

Cain

2021

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

Overdose death rates caused by psychostimulants have increased by 22.3% annually from 2008 to 2017. Cue-evoked drug craving progressively increases and contributes to perpetual relapse. Preclinical models have determined that glutamate receptor plasticity within the nucleus accumbens (NAc) drives amplified cue-evoked drug seeking after prolonged abstinence (>40 days).Isolated condition (IC) rearing increases cocaine and amphetamine (AMP) self-administration and cue-induced reinstatement. We tested the hypothesis that housing in the IC will augment AMP seeking after short and prolonged abstinence from AMP self-administration when compared with rats reared in the enrichment condition (EC). EC and IC male rats acquired stable AMP or SAL self-administration and were tested in a cue-induced AMP-seeking test after 1 and 40 days of abstinence. After the seeking test, the whole NAc was extracted and prepared for western blot analysis. Results indicate that IC rats had more active lever presses during a brief extinction interval and during the cue-induced seeking test. After 40 days of abstinence, IC rats had more active lever presses than EC rats during the cue-induced seeking test. Western blots indicated that the expression ratio between GluA1:mGlur5 was reduced only in IC-AMP-trained rats and the ratio between GluA1:mGlur1 was positively correlated with AMP seeking after prolonged abstinence in IC-AMP rats.These results indicate that IC housing engenders a vulnerable phenotype prone to persistent AMP seeking. The behavioural momentum of this vulnerable phenotype is further revealed when AMP-associated cues are presented following prolonged abstinence.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Isolation housing elevates amphetamine seeking independent of nucleus accumbens glutamate receptor adaptations

Garcia

Cain

2021

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…Other potential factors which could contribute to the effects of EE include increased expression of neurotrophin-3 and insulin-like growth factor-1 [ 87 ], improvements of N-methyl-D-aspartate receptor histone acetylation [ 190 ], and changes in metabotropic glutamate receptor mGluRs [ 191 , 192 ], consequently leading to downstream activation of other undiscussed pathways.…”

Section: Potential Molecular Mechanisms Associated With Ee In the Brainmentioning

confidence: 99%

The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease

2022

View full text Add to dashboard Cite

Environmental enrichment (EE) is an environmental paradigm encompassing sensory, cognitive, and physical stimulation at a heightened level. Previous studies have reported the beneficial effects of EE in the brain, particularly in the hippocampus. EE improves cognitive function as well as ameliorates depressive and anxiety-like behaviors, making it a potentially effective neuroprotective strategy against neurodegenerative diseases such as Alzheimer’s disease (AD). Here, we summarize the current evidence for EE as a neuroprotective strategy as well as the potential molecular pathways that can explain the effects of EE from a biochemical perspective using animal models. The effectiveness of EE in enhancing brain activity against neurodegeneration is explored with a view to differences present in early and late life EE exposure, with its potential application in human being discussed. We discuss EE as one of the non pharmacological approaches in preventing or delaying the onset of AD for future research.

show abstract

“…Further, a single treatment with LY341495 improved isolated mice performance in the Y maze test but not in the novel object recognition test, while repeating the treatments were efficient for both tasks (87,89). Conversely, mGluR2/3 agonist, LY379268 , has also improved recognition memory impairment in SI rats (87,90). Earlier investigations have suggested that stress and anxiety-like behaviors have appeared due to a mediator called the Corticotropin-releasing factor (CRF).…”

Section: Antidepressant Drugsmentioning

confidence: 99%

Cognitive Consequences of Social Isolation During COVID-19: side effects and treatments

Taherizadeh¹,

Rahmani²,

Alidadi³

et al. 2021

Preprint

View full text Add to dashboard Cite

Objective: During the COVID-19 pandemic, quarantine and staying at home is advised. The social relationship between people has become deficient, and human social isolation (SI) has become the consequence of this situation. It was shown that SI has made changes in hippocampal neuroplasticity, which will lead to poor cognitive function and behavioral abnormalities. There is a connection between SI, learning, and memory impairments. In addition, anxiety-like behavior and increased aggressive mood in long-term isolation have been revealed during the COVID-19 outbreak. Methods: Term searches was done in Google Scholar, Scopus, ScienceDirect, Web of Science and PubMed databases as well as hand searching in key resource journals from 1979–2020. Results: Studies have shown that some drug administrations may positively affect or even prevent social isolation consequences in animal models. These drug treatments have included opioid drugs, anti-depressants, Antioxidants, and herbal medications. In addition to drug interventions, there are non-drug treatments that include an enriched environment, regular exercise, and music. Conclusion: This manuscript aims to review improved cognitive impairments induced by SI during COVID-19.

show abstract

Environmental enrichment and a selective metabotropic glutamate receptor2/3 (mGluR2/3) agonist suppress amphetamine self-administration: Characterizing baseline differences

Cited by 7 publications

References 48 publications

Isolation housing elevates amphetamine seeking independent of nucleus accumbens glutamate receptor adaptations

Isolation housing elevates amphetamine seeking independent of nucleus accumbens glutamate receptor adaptations

The Molecular Effects of Environmental Enrichment on Alzheimer’s Disease

Cognitive Consequences of Social Isolation During COVID-19: side effects and treatments

Contact Info

Product

Resources

About