Environmental Endocrine Disruptors and Endometriosis

Rumph, Jelonia T.; Stephens, Victoria R.; Archibong, Anthony E.; Osteen, Kevin G.; Bruner‐Tran, Kaylon L.

doi:10.1007/978-3-030-51856-1_4

Cited by 20 publications

(16 citation statements)

References 88 publications

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“…The endocrine system is an assembly of hormone-secreting tissues that promote downstream interactions between hormones and their highly specific receptors to regulate essential life processes including growth and development, tissue function, metabolism, and reproduction (Hiller-Sturmhofel and Bartke, 1998). EDCs are classically defined as exogenous chemicals that interfere with the normal physiological functions of the endocrine system potentially causing adverse health effects and promotion of disease (Rumph et al, 2020). Unfortunately, due to industrialization, exposure to EDCs is inevitable and occurs across the lifespan of most mammals.…”

Section: Environmental Endocrine Disrupting Chemicalsmentioning

confidence: 99%

“…This study sparked a surge in subsequent studies that sought to examine the potential link between TCDD exposure and the development of endometriosis (Bois and Eskenazi, 1994;Eskenazi et al, 2002;Heilier et al, 2005;Matta et al, 2021). Nevertheless, epidemiologic data is mixed with a number of studies failing to identify a clear association between TCDD exposure and endometriosis (reviewed in Rumph et al, 2020).…”

Section: Environmental Endocrine Disrupting Chemicalsmentioning

confidence: 99%

“…Taken together, these data provide evidence that EDC exposure can promote the development of both endometriosis and adenomyosis in multiple species. However, while numerous studies support a role of TCDD in the development of endometriosis in women (reviewed by Rumph et al, 2020), to our knowledge, a potential role of this compound and the development of adenomyosis in women has not been investigated.…”

Section: Environmental Endocrine Disrupting Chemicalsmentioning

confidence: 99%

“…One of the most well-known pharmaceutical EDC exposures was as a consequence of diethylstilbestrol (DES) consumption by pregnant women in an attempt to mitigate the risk of miscarriage, preterm birth, and other pregnancy-related complications (Rumph et al, 2020). DES is a synthetic, highly potent estrogen that was initially prescribed to women with high-risk pregnancies.…”

Section: Diethylstilbestrolmentioning

confidence: 99%

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The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis

et al. 2022

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Women with endometriosis, the growth of endometrial glands and stroma outside the uterus, commonly also exhibit adenomyosis, the growth of endometrial tissues within the uterine muscle. Each disease is associated with functional alterations in the eutopic endometrium frequently leading to pain, reduced fertility, and an increased risk of adverse pregnancy outcomes. Although the precise etiology of either disease is poorly understood, evidence suggests that the presence of endometriosis may be a contributing factor to the subsequent development of adenomyosis as a consequence of an altered, systemic inflammatory response. Herein, we will discuss the potential role of exposure to environmental toxicants with endocrine disrupting capabilities in the pathogenesis of both endometriosis and adenomyosis. Numerous epidemiology and experimental studies support a role for environmental endocrine disrupting chemicals (EDCs) in the development of endometriosis; however, only a few studies have examined the potential relationship between toxicant exposures and the risk of adenomyosis. Nevertheless, since women with endometriosis are also frequently found to have adenomyosis, discussion of EDC exposure and development of each of these diseases is relevant. We will discuss the potential mechanisms by which EDCs may act to promote the co-development of endometriosis and adenomyosis. Understanding the disease-promoting mechanisms of environmental toxicants related to endometriosis and adenomyosis is paramount to designing more effective treatment(s) and preventative strategies.

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Section: Environmental Endocrine Disrupting Chemicalsmentioning

confidence: 99%

Section: Environmental Endocrine Disrupting Chemicalsmentioning

confidence: 99%

Section: Environmental Endocrine Disrupting Chemicalsmentioning

confidence: 99%

Section: Diethylstilbestrolmentioning

confidence: 99%

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The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis

et al. 2022

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“…Besides, as mentioned before, there is a large part of endometriosis that is related to non-genetic parameters, either through stochastic reasons, or through environmental exposures. Nevertheless, until now no really convincing causal environmental factor has been found in endometriosis, as recently reviewed [ 102 ], albeit some scanty evidence suggest potential links with bisphenol A, phthalates and organochlorinated components [ 103 ].…”

Section: Discussionmentioning

confidence: 99%

Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing

Lalami

Abo

Borghese

et al. 2021

IJMS

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This review aims at better understanding the genetics of endometriosis. Endometriosis is a frequent feminine disease, affecting up to 10% of women, and characterized by pain and infertility. In the most accepted hypothesis, endometriosis is caused by the implantation of uterine tissue at ectopic abdominal places, originating from retrograde menses. Despite the obvious genetic complexity of the disease, analysis of sibs has allowed heritability estimation of endometriosis at ~50%. From 2010, large Genome Wide Association Studies (GWAS), aimed at identifying the genes and loci underlying this genetic determinism. Some of these loci were confirmed in other populations and replication studies, some new loci were also found through meta-analyses using pooled samples. For two loci on chromosomes 1 (near CCD42) and chromosome 9 (near CDKN2A), functional explanations of the SNP (Single Nucleotide Polymorphism) effects have been more thoroughly studied. While a handful of chromosome regions and genes have clearly been identified and statistically demonstrated as at-risk for the disease, only a small part of the heritability is explained (missing heritability). Some attempts of exome sequencing started to identify additional genes from families or populations, but are still scarce. The solution may reside inside a combined effort: increasing the size of the GWAS designs, better categorize the clinical forms of the disease before analyzing genome-wide polymorphisms, and generalizing exome sequencing ventures. We try here to provide a vision of what we have and what we should obtain to completely elucidate the genetics of this complex disease.

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Bisphenol A and polycystic ovary syndrome in human: A systematic review

Urbanetz,

Soares‐Junior,

dos Santos Simões

et al. 2024

Intl J Gynecology & Obste

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BackgroundPolycystic ovary syndrome (PCOS) is an endocrine disorder characterized by anovulation, hyperandrogenism, and polycystic ovarian morphology. Its etiology is uncertain and one of the hypotheses is that environmental factors, such as the bisphenol A (BPA) endocrine disruptor, may be involved.ObjectiveTo investigate the association between exposure to BPA and PCOS.Search StrategyResearch was conducted focusing on studies published in English, Portuguese, and Spanish from January 2001 to March 2023 and available in Embase, Medline/PubMed, Rima, Lilacs, Scielo, Google academic, and SCI databases.Selection CriteriaStudies in humans that evaluated the association between exposure to BPA and a diagnosis of PCOS.Data Collection and AnalysisFollowing PRISMA guidelines, study characteristics and relevant data were extracted.Main ResultsSelection of 15 case–control and 7 cross‐sectional studies with a total of 1682 PCOS patients. The studies were carried out in China, Poland, Turkey, Japan, Greece, Italy, the USA, Iran, Iraq, Egypt, India, Czechia, and Slovakia. A positive relationship between exposure to BPA and PCOS was described in19 studies (1391 [82.70%] of the PCOS patients). The fluids used in the studies were serum, urine, plasma, and follicular fluid. BPA was measured by ELISA and by chromatography (HPLC, HPLC‐MS/MS, GC–MS, and GC–MS/MS). Diagnosis of PCOS used Rotterdam criteria in 15, NIH 1999 in 3, AE&PCOS Society in 2, similar to the Rotterdam criteria in 1, and criteria not informed in 1. Androgens were measured in 16 studies; in 12, hyperandrogenism was positively associated with BPA. BPA level was related to body mass index (BMI) in studies. In 15 studies independently of BMI, women with PCOS had higher BPA levels. Carbohydrate metabolism disorders were evaluated in 12 studies and in 6 a positive correlation was found with BPA levels. Lipid profile was evaluated in seven studies and in only one the correlation between lipid profile and BPA levels was present.ConclusionsExposure to BPA is positively associated with PCOS, mainly with the hyperandrogenism.

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Environmental Endocrine Disruptors and Endometriosis

Cited by 20 publications

References 88 publications

The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis

The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis

Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing

Bisphenol A and polycystic ovary syndrome in human: A systematic review

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