Environmental Effects Of Monosodium Glutamate On (NF-κB) Levels In The Male Reproductive System Of Rats

Abstract

Monosodium glutamate (MSG) has been identified as a food additive that Adversely affects MSG use on the reproductive efficiency by several mechanisms, this study was carried out to determine its role in stimulating the immune response in the reproductive system by estimating levels of NF-κB in serum and of its expression in reproductive organs. Thirty sex males rats were used in this study each included 12 male rats. Male rats A and B are receiving 60 and 120 mg/kg for 28 days respectively male rats of the control group were left without treatment for the period of the experiment. The levels of Nuclear factor-kappa NF-κB in serum and tissue fluid of testes and epididymis were measured. histological changes in addition to detection NF-κB expression were studying in testes and epididymis. Results of the present study recorded the toxic effect of MSG as it caused an elevation in the levels of NF-κB in serum, testicular, and epididymis tissue fluid. histological alternation in the reproductive organs was observed to represent detachment and vacuolation of the seminal epithelium, degeneration of spermatogenesis edema in a lumen in testicular tissues. Epididymal sections appeared to sever necrosis, degeneration in the epithelial layer and stereocilia, and the lumen of the epididymis. Also there was an increasing density of NFκB protein immunoreactivity in both testis and epididymis.

Disruptive consequences of monosodium glutamate on male reproductive function: A review

“…Egbuonu et al ( Al-Husseini et al, 2022 ) reported that the ingestion of MSG might adversely alter the functional capacity of the prostate. Another recent study reported the toxic effect of MSG as it caused an elevation in the levels of NFκB in serum, testicular, and epididymis tissue fluid ( Al-Husseini et al, 2022 ).…”

“…Egbuonu et al ( Al-Husseini et al, 2022 ) reported that the ingestion of MSG might adversely alter the functional capacity of the prostate. Another recent study reported the toxic effect of MSG as it caused an elevation in the levels of NFκB in serum, testicular, and epididymis tissue fluid ( Al-Husseini et al, 2022 ). Histological alternation in the reproductive organs was also reported to represent detachment and vacuolation of the seminal epithelium, degeneration of spermatogenesis edema in a lumen in testicular tissues ( Al-Husseini et al, 2022 ).…”

“…Another recent study reported the toxic effect of MSG as it caused an elevation in the levels of NFκB in serum, testicular, and epididymis tissue fluid ( Al-Husseini et al, 2022 ). Histological alternation in the reproductive organs was also reported to represent detachment and vacuolation of the seminal epithelium, degeneration of spermatogenesis edema in a lumen in testicular tissues ( Al-Husseini et al, 2022 ). The study by Wang et al ( Wang et al, 2021 ) documented that MSG can cause reproductive toxicity to male mice by damaging GnRH neurons thus the hallmark of male reproductive toxicity.…”

Вплив Модуляторів Циркадіанного Ритму На Екскреторну Та Натрійрегулювальну Функцію Нирок Щурів За Умов Гострого Десинхронозу Та Ліпополісахарид-Індукованої Системної Запальної Відповіді

“…Введення щурам глутамату натрію, який змінює експресію генів центрального осцилятора та активує прозапальні фактори транскрипції, наприклад, NF-κB [31,37], відповідно до наших даних, призводило до значно більшого зниження ШКФ та реабсорбції натрію, ніж це спостерігалося після відтворення ГД на тлі ЛПС-індукованої СЗВ. За даними інших дослідників, за умов природного освітлення щурів лише довготривале споживання глутамату натрію у значно вищій дозі (320 мг/кг маси тіла) виявляє суттєве порушення екскреторної функції нирок, що автори пов'язують з розвитком оксидативного стресу [38].…”