Environmental complexity does affect scopolamine induced changes in activity

Stewart, Warren J.

doi:10.1016/0304-3940(75)90056-7

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…Stewart (19) reported that scopolamine-treated rats had a higher level of ambulation than control rats when tested in a simple open field (36 in. x 36 in.).…”

Section: Apparatusmentioning

confidence: 99%

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Use of Activity Measures in Behavioral Toxicology

Reiter¹

1978

Environmental Health Perspectives

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Locomotor activity measurements have been used extensively to evaluate chemically-induced changes in CNS function. This paper focuses on several factors including apparatus, age, biological rhythm, and social setting, which influence both locomotor activity levels per se and chemically induced changes in these activity levels. These data illustrate that failure to recognize, specify, and consider these factors is likely to result in equivocal studies subject to possible misinterpretation.

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“…Stewart (19) reported that scopolamine-treated rats had a higher level of ambulation than control rats when tested in a simple open field (36 in. x 36 in.).…”

Section: Apparatusmentioning

confidence: 99%

“…Since a number of environmental factors are known to influence activity levels [e.g., size and illumination (21) and spatial complexity (19)], the finding that environmental complexity interacts with drug- (19) and toxicant-induced (18) activity changes illustrates the need to consider these interactions in behavioral toxicity testing.…”

Section: Apparatusmentioning

confidence: 99%

Use of Activity Measures in Behavioral Toxicology

Reiter¹

1978

Environmental Health Perspectives

View full text Add to dashboard Cite

show abstract

“…The second probable source for these differences in activity is the test environment and its influence on the animal. Since a number of environmental factors are known to influence activity levels [e.g., size and illumination (21) and spatial complexity (19)], the finding that environmental complexity interacts with drug-( 19) and toxicant-induced (18) activity changes illustrates the need to consider these interactions in behavioral toxicity testing.…”

Section: Apparatusmentioning

confidence: 99%