Environmental colonization and transmission of carbapenem-resistant enterobacteriaceae and carbapenem-resistant Acinetobacter baumannii in intensive care unit

Mirza, Shahzad; Trivedi, PriyalP; Gandham, NageswariR; Das, NikunjaKumar; Misra, Rabindra Nath; Kharel, Rashmi; Joe, Susan

doi:10.4103/mjdrdypu.mjdrdypu_210_21

Cited by 1 publication

(2 citation statements)

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“…The present study showed that the most frequently isolated critical GNB was K. pneumoniae followed by Acinetoacter species, E. coli and P. aeruginosa. This result is similar to reports from India [21], Nigeria [22,23] and Alexandria University [24], where K. pneumoniae was most commonly detected isolates from the environmental surfaces of the ICUs. In contrast to the present study, Acinetobacter species, A. baumannni was the most persistently detected isolate in ICUs [25,26].…”

Section: Discussionsupporting

confidence: 90%

“…[30]. Similarly, a study by Trivedi et al reported that carbapenemase production was highest in K. pneumoniae followed by E. coli, P. aeruginosa and Acinetobacter species [21]. Isolation of drug-resistant K. pneumoniae from environmental surfaces in the NICU is an important risk factor for neonatal infections, including septicemia, urinary tract infections, pneumonia, and soft tissue infections.…”

Section: Discussionmentioning

confidence: 98%

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Multidrug-resistant and carbapenemase-producing critical gram-negative bacteria isolated from the intensive care unit environment in Amhara region, Ethiopia

Kindu,

Moges,

Ashagrie

et al. 2023

PLoS ONE

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Background Intensive care units are units where healthcare-associated infections (HAIs) are common and antimicrobial resistance rates are increasing. Microbial contamination in hospital environment plays an important role in the development of HAIs. Intervention-based improvements in infection prevention and control at national and facility level are critical for the containment of antimicrobial resistance and prevention of HAIs. Objectives This study aimed to determine the distribution of multidrug-resistant and carbapenemase-producing critical gram negative bacteria (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa and Acinetobacter species) and their antibiotic resistance in intensive care unit environmental surfaces at the University of Gondar and Felege Hiwot Comprehensive Specialized Hospitals. Methods This was multicenter hospital-based cross sectional study. Environmental samples were swabbed from all intensive care units using a normal saline moistened-sterile cotton tip stick. Bacteria culturing and antibiotic susceptibility testing were performed following standard microbiological techniques. Selected meropenem-resistant isolates were phenotypically assessed for carbapenemase production using modified and simplified carbapenem inactivation methods. Results From a total of 384 environmental samples analyzed, 126 (32.8%) showed growth and 162 isolates were identified. K. pneumoniae (79/162, 48.8%) was the commonest isolate followed by Acinetobacter species (51/162, 31.5%), E. coli (19/162, 11.7%) and P. aeruginosa (13/162, 8.0%). Multidrug-resistant and carbapenemase-producing isolates were detected on most hospital environment surface types, especially from the baby bed sets and incubators. The most common multidrug-resistant and principal carbapenemase producer was K. pneumoniae, with rates of 71(89.9%) and 24(85.7%), respectively. Conclusion This study revealed the distribution of multidrug-resistant and carbapenemase-producing critical gram negative bacteria in the environment of intensive care unit. Higher detection rate of multidrug-resistant and carbapenemase-producing K. pneumoniae on most environmental surfaces calls for urgent control action and further attention.

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