Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk

Courtier, Audrey; Potheret, Damien; Giannoni, Patrizia

doi:10.1016/j.lfs.2022.120689

Cited by 4 publications

(4 citation statements)

References 257 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, by advancing our understanding of the role of microbiota in the development of asthma, it becomes possible to further evaluate the critical roles played by microbiota in human chronic airway inflammation. This has the potential to lead to the development of novel therapeutic strategies involving dietary interventions (SCFA), probiotics ( Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria ), fecal microbiota transplantation, or selective bacterial manipulation to modify microbiota ( 98 ). This review posits that investigating the relationship between microbiota changes and the development of lung diseases provides an avenue to identify new therapeutic targets.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Cross-domain microbiomes: the interaction of gut, lung and environmental microbiota in asthma pathogenesis

Zhang,

Zheng,

Luo

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

Recent experimental and epidemiological studies underscore the vital interaction between the intestinal microbiota and the lungs, an interplay known as the “gut-lung axis”. The significance of this axis has been further illuminated following the identification of intestinal microbial metabolites, such as short-chain fatty acids (SCFA), as key mediators in setting the tone of the immune system. Through the gut-lung axis, the gut microbiota and its metabolites, or allergens, are directly or indirectly involved in the immunomodulation of pulmonary diseases, thereby increasing susceptibility to allergic airway diseases such as asthma. Asthma is a complex outcome of the interplay between environmental factors and genetic predispositions. The concept of the gut-lung axis may offer new targets for the prevention and treatment of asthma. This review outlines the relationships between asthma and the respiratory microbiome, gut microbiome, and environmental microbiome. It also discusses the current advancements and applications of microbiomics, offering novel perspectives and strategies for the clinical management of chronic respiratory diseases like asthma.

show abstract

Section: Conclusion and Prospectsmentioning

confidence: 99%

Cross-domain microbiomes: the interaction of gut, lung and environmental microbiota in asthma pathogenesis

Zhang,

Zheng,

Luo

et al. 2024

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Despite some contradictory research [ 56 ], an increasing body of experimental proof provides confirmation that BMAA plays a significant role in neurodegenerative diseases (ND) [ 57 , 58 , 59 ]. Some analytical methods related to liquid chromatography and fluorescence-based detection of BMAA, especially in older literature, may be prone to overestimation of BMAA concentration in studied samples and should be treated cautiously [ 60 , 61 ].…”

Section: Cyanobacterial Toxinsmentioning

confidence: 99%

“…Most animal models used for studying BMAA were based on investigating BMAA effects in the brain and other organs [ 59 ]. Thus, Xie and co-authors reported that in their experiments, less than 1% of total BMAA detected in adult mice plasma was taken in the brain [ 71 ], i.e., blood-brain barrier (BBB) was not easily permeable for BMAA.…”

Section: Cyanobacterial Toxinsmentioning

confidence: 99%

Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases

Nugumanova

Ponomarev

Askarova

et al. 2023

Toxins

View full text Add to dashboard Cite

Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, and terrestrial ecosystems. The health significance of these metabolites, which include genotoxic- and neurotoxic agents, is confirmed by continued associations between the occurrence of animal and human acute toxic events and, in the long term, by associations between cyanobacteria and neurodegenerative diseases. Major mechanisms related to the neurotoxicity of cyanobacteria compounds include (1) blocking of key proteins and channels; (2) inhibition of essential enzymes in mammalian cells such as protein phosphatases and phosphoprotein phosphatases as well as new molecular targets such as toll-like receptors 4 and 8. One of the widely discussed implicated mechanisms includes a misincorporation of cyanobacterial non-proteogenic amino acids. Recent research provides evidence that non-proteinogenic amino acid BMAA produced by cyanobacteria have multiple effects on translation process and bypasses the proof-reading ability of the aminoacyl-tRNA-synthetase. Aberrant proteins generated by non-canonical translation may be a factor in neuronal death and neurodegeneration. We hypothesize that the production of cyanopeptides and non-canonical amino acids is a more general mechanism, leading to mistranslation, affecting protein homeostasis, and targeting mitochondria in eukaryotic cells. It can be evolutionarily ancient and initially developed to control phytoplankton communities during algal blooms. Outcompeting gut symbiotic microorganisms may lead to dysbiosis, increased gut permeability, a shift in blood-brain-barrier functionality, and eventually, mitochondrial dysfunction in high-energy demanding neurons. A better understanding of the interaction between cyanopeptides metabolism and the nervous system will be crucial to target or to prevent neurodegenerative diseases.

show abstract

“…The reports presented in Table S1 suggest that exposure to BMAA can occur through the same routes of exposure that are known for other cyanotoxins: through drinking water (e.g., in a case when a cyanobacterial mass development occurs in a drinking water reservoir), recreational activities (e.g., swimming, canoeing or bathing), the aquatic food web, terrestrial plants and animals and food supplements [53,[74][75][76]. Synthesized by cyanobacteria and microalgae, BMAA is transported through some food webs in aquatic ecosystems from zooplankton and benthos invertebrates, planktivorous fish, shellfish, snails and crustaceans to carnivorous fish and mammals.…”

Section: Exposure To Bmaamentioning

confidence: 99%

Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases

et al. 2022

View full text Add to dashboard Cite

In the present review we have discussed the occurrence of β-N-methylamino-L-alanine (BMAA) and its natural isomers, and the organisms and sample types in which the toxin(s) have been detected. Further, the review discusses general pathogenic mechanisms of neurodegenerative diseases, and how modes of action of BMAA fit in those mechanisms. The biogeography of BMAA occurrence presented here contributes to the planning of epidemiological research based on the geographical distribution of BMAA and human exposure. Analysis of BMAA mechanisms in relation to pathogenic processes of neurodegeneration is used to critically assess the potential significance of the amino acid as well as to identify gaps in our understanding. Taken together, these two approaches provide the basis for the discussion on the potential role of BMAA as a secondary factor in neurodegenerative diseases, the rationale for further research and possible directions the research can take, which are outlined in the conclusions.

show abstract

Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk

Cited by 4 publications

References 257 publications

Cross-domain microbiomes: the interaction of gut, lung and environmental microbiota in asthma pathogenesis

Cross-domain microbiomes: the interaction of gut, lung and environmental microbiota in asthma pathogenesis

Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases

Environmental Neurotoxin β-N-Methylamino-L-alanine (BMAA) as a Widely Occurring Putative Pathogenic Factor in Neurodegenerative Diseases

Contact Info

Product

Resources

About