Environmental and sensitization variations among asthma and/or rhinitis patients between 2008 and 2018 in China

Wang, Wanjun; Wang, Jianhong; Song, Guihua; Xie, Hua; Lin, Xiaoping; Chai, Renjie; Zhu, Rongfei; He, Yuqing; Tang, Jun; Wang, Junge; Yang, Jinghua; Zhi, Lili; Wu, Lin; Jiang, Yan; Zhou, Xiaoqin; Huang, Dongming; Wang, Ning; Xu, Rui; Gao, Yuan; Chen, Zhimin; Liu, Jinling; Han, Xiaoli; Tan, Guolin; Wu, Jinzhun; Zhao, Deyu; Chen, Jianjun; Zhang, Xiwei; Li, Mengrong; Sun, Yuemei; Jiang, Yi; Zhang, Weitian; Qiu, Qianhui; Liu, Chuanhe; Yin, Jie; Hao, Guodong; Li, Hua-Bin; Xu, Yongsheng; Chen, Shaohua; Zhang, Hua; Chen, Shi; Meng, Juan; Zeng, Dan; Tang, Wei; Hao, Chuangli; Li, Jing; Zhong, Nanshan

doi:10.1002/clt2.12116

Cited by 15 publications

(16 citation statements)

References 33 publications

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“…It is well known that HDMs, as the most prevalent aeroallergen, sensitized over 90% of atopic patients in Asia 15 . Compared with a recent national cross‐sectional study conducted from 2008 to 2018, HDMs were still the most popular aeroallergens in China 16 . In our study, HDMs and pollens sensitization was observed in nearly half of the cases of AA patients in the eastern and western regions, respectively, consistent with Lebanese asthmatic patients 17 .…”

Section: Discussionsupporting

confidence: 64%

Patterns of aeroallergen sensitization in asthma patients identified by latent class analysis: A cross‐sectional study in China

Zhang,

Luo,

et al. 2023

Clinical & Translational All

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Background: This cross-sectional study aimed to identify latent sensitization profiles of asthma patients in mainland China, unveiling the association between regional differences and sensitization patterns.Methods: 1056 asthma participants from 10 medical centers divided into eastern and western cohorts were clustered into four individual sensitization patterns, respectively, by using an unsupervised statistical modeling method, latent class analysis (LCA), based on the levels of 12 aeroallergens specific IgE reactivities.

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Section: Discussionsupporting

confidence: 64%

Patterns of aeroallergen sensitization in asthma patients identified by latent class analysis: A cross‐sectional study in China

Zhang,

Luo,

et al. 2023

Clinical & Translational All

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“…30 In China, national surveys have reported increased allergy prevalence in children between 2008 and 2018 for tree pollens (3% sensitisation to black poplar in 2008 vs 6% in 2018) and dust mite allergens (32% vs 65%). 28 Similar increasing trends were reported in South Korea between 2009 and 2018. 31 The International Study on Asthma and Allergies in Childhood reported a global increasing trend in the prevalence of rhinoconjunctivitis caused by airborne allergens (typically presenting as sneezing or a runny or blocked nose and itchy, watery eyes), between the mid-1990s and early 2000s.…”

Section: Allergies To Airborne Allergenssupporting

confidence: 72%

“…Whereas, globally, dust mite, cockroach, and mould remain a source of major airborne allergens. [24][25][26][27][28] Sensitisation rates and allergy to airborne allergens, including grass pollen, tree pollen, and dust mites, appear to have increased globally in the 21st century. For example, studies conducted in northern Sweden show increased sensitisation rates in children aged 11-12 years in 2010 compared with 2000 (37% positive for allergen-specific IgE in 2010 vs 28% in 2000).…”

Section: Allergies To Airborne Allergensmentioning

confidence: 99%

Allergies to food and airborne allergens in children and adolescents: role of epigenetics in a changing environment

Koppelman¹,

Vicedo-Cabrera²,

Andersen³

et al. 2022

The Lancet Child & Adolescent Health

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“…Therefore, a previous study indicated that tIgE developed as a Th2 biomarker involved in regulating the Th2 inflammatory response [ 32 ]. Dust mites are the main allergens in Southern China [ 33 , 34 ], both in airway and skin allergic diseases. Allergen immunotherapy (AIT) is the only treatment for allergic diseases [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study

Hou

et al. 2023

JCM

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Background: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevalence of allergies. Methods: This was a real-world, cross-sectional study of 1273 outpatients diagnosed with one or more allergic diseases in Guangzhou, the most populated city of southern China, with leading industrial and commercial centers, between April 2021 and March 2022. Seven allergic diseases (allergic rhinitis (AR), asthma (AS)/cough variant asthma (CVA), atopic dermatitis (AD)/eczema, food allergy (FA), allergic conjunctivitis (AC), drug allergy (DA), and anaphylaxis) were assessed. Positive rates of sensitization to different allergens were measured using an allergen detection system of the UniCAP (Pharmacia Diagnostics, Sweden) instrument platform to compare the groups of allergic multimorbidities against a single entity. Results: There were 659 (51.8%) males and 614 (48.2%) females aged from 4 months to 74 years included in the analysis. The study participants who were diagnosed with allergic diseases had an average of 1.6 diagnoses. Overall, 46.5% (592 of 1273) of the patients had more than one allergic condition, and allergic rhinitis was the most common type of multimorbidity. Women were more likely to suffer from an allergic disease alone, whereas allergic multimorbidities were more likely to be diagnosed in men (p = 0.005). In addition, allergic multimorbidities were common in all age groups, with an incidence ranging from 37.1% to 57.4%, in which children and adolescents were more frequently diagnosed with allergic multimorbidities than adults (18–60 years old) (all p < 0.05). Allergic multimorbidity was observed throughout the year. A difference in the positive rate of allergens sensitization and total immunoglobulin E (tIgE) levels between different allergic multimorbidities was observed. Conclusions: Allergic multimorbidities were very commonly found in nearly half of all patients with allergies. The proportion of allergic multimorbidities varied with the type of disease, sex, age, and allergen distribution pattern. These findings may help clinicians to develop “One health” strategies for the clinical management of allergic diseases.

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Environmental and sensitization variations among asthma and/or rhinitis patients between 2008 and 2018 in China

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 15 publications

References 33 publications

Patterns of aeroallergen sensitization in asthma patients identified by latent class analysis: A cross‐sectional study in China

Patterns of aeroallergen sensitization in asthma patients identified by latent class analysis: A cross‐sectional study in China

Allergies to food and airborne allergens in children and adolescents: role of epigenetics in a changing environment

Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional Study

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