Environmental and occupational exposure to bisphenol A and endometriosis: urinary and peritoneal fluid concentration levels

Simonelli, Angela; Guadagni, Rossella; Franciscis, Pasquale De; Colacurci, Nicola; Pieri, Maria; Basilicata, Pascale; Pedata, Paola; Lamberti, Monica; Sannolo, Nicola; Miraglia, Nadia

doi:10.1007/s00420-016-1171-1

Cited by 63 publications

(40 citation statements)

References 55 publications

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“…Furthermore, these findings were not confirmed by a subsequent prospective case-control study authored by Cobellis et al involving 11 healthy women aged 35-39 years and 58 women aged 33-39 years with endometriosis; in this study, urinary BPA levels were detected in 51.7% of 58 patients with endometriosis suggesting possible relationship between endometriosis and BPA [118]. In the same line are the results reported in a prospective case-control study carried out by Simonelli et al enrolling 60 women with endometriosis and 68 healthy women aged 30-40 years, in which higher urinary BPA levels were observed in women affected by endometriosis [119]. Focusing on ovarian endometriosis, Rashidi et al in a prospective case-control study on 50 Iranian women with endometrioma and 50 healthy women aged 32-37 years detected higher urinary BPA levels in patients with endometrioma [120].…”

Section: Observational Studies In Humanssupporting

confidence: 86%

“…Several observational studies have been carried out to investigate the possible association between BPA exposure and the occurrence of endometriosis in humans [116][117][118][119][120][121][122]. The possible link between serum BPA levels and the occurrence of endometriosis has been firstly assessed by a prospective cross-sectional study in 2007 [116].…”

Section: Observational Studies In Humansmentioning

confidence: 99%

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Bisphenol A: an emerging threat to female fertility

Pivonello

Muscogiuri

Nardone

et al. 2020

Reprod Biol Endocrinol

168

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Bisphenol-A (BPA) has been reported to be associated to female infertility. Indeed, BPA has been found to be more frequently detected in infertile women thus leading to hypothesize a possible effect of BPA on natural conception and spontaneous fecundity. In addition, in procedures of medically assisted reproduction BPA exposure has been found to be negatively associated with peak serum estradiol levels during gonadotropin stimulation, number of retrieved oocytes, number of normally fertilized oocytes and implantation. BPA deleterious effects are more critical during perinatal exposure, causing dysregulation of hypothalamic-pituitary-ovarian axis in pups and adults, with a precocious maturation of the axis through a damage of GnRH pulsatility, gonadotropin signaling and sex steroid hormone production. Further, BPA exposure during early lifestage may have a transgenerational effect predisposing the subsequent generations to the risk of developing BPA related disease. Experimental studies suggested that prenatal, perinatal and postnatal exposure to BPA can impair several steps of ovarian development, induce ovarian morphology rearrangement and impair ovarian function, particularly folliculogenesis, as well as can impair uterus morphology and function, in female adult animal and offspring. Finally, studies carried out in animal models have been reported the occurrence of endometriosis-like lesions after BPA exposure. Moreover, BPA exposure has been described to encourage the genesis of PCOS-like abnormalities through the impairment of the secretion of sex hormones affecting ovarian morphology and functions, particularly folliculogenesis. The current manuscript summarizes the evidence regarding the association between BPA exposure and female infertility, reviewing both clinical and preclinical studies.

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Section: Observational Studies In Humanssupporting

confidence: 86%

Section: Observational Studies In Humansmentioning

confidence: 99%

Bisphenol A: an emerging threat to female fertility

Pivonello

Muscogiuri

Nardone

et al. 2020

Reprod Biol Endocrinol

168

View full text Add to dashboard Cite

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“…The hypothesis that exposure to bisphenols may enhance the risk of endometriosis risk is biologically plausible, as mentioned above. However, there has been little epidemiological research on this association to date, with an increased endometriosis risk reported by some authors [39,40] but no association by others [38,41]. This discrepancy may be attributable to differences in the criteria for selecting participants or in the timing of sample collections.…”

Section: Discussionmentioning

confidence: 99%

“…The present findings are in agreement with the study by Rashidi et al [37], who described an OR of 1.7 (95%CI 1.4-2.2) for the association between urinary BPA concentrations and endometriosis risk after adjustment for age, BMI, parity, and education, although urinary creatinine was not included as a covariate. Simonelli et al [40] also reported unadjusted associations between exposure and endometriosis, evaluated with the Student's t-test. This association is also supported by studies of mouse models of endometriosis, which related exposure to bisphenols in adulthood to increased endometriosis lesion growth and atretic oocyte number, disruption of the ovarian steroidogenic pathway, an increase in periglandular fibrosis, and the upregulation of matrix-remodeling enzymes [33,42].…”

Section: Discussionmentioning

confidence: 99%

Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study

Peinado

Lendínez

Sotelo

et al. 2020

IJERPH

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Aim: The aim of this study was to explore associations of urinary concentrations of bisphenols A (BPA), S (BPS), and F (BPF) and of thiobarbituric acid reactive substances (TBARS) with the risk of endometriosis in women of childbearing age. Methods: This case–control study enrolled 124 women between January 2018 and July 2019: 35 women with endometriosis (cases) and 89 women without endometriosis undergoing abdominal surgery for other reasons (controls). Endometriosis was diagnosed (cases) or ruled out (controls) by laparoscopic inspection of the pelvis and the biopsy of suspected lesions (histological diagnosis). Fasting urine samples were collected before surgery to determine concentrations of BPA, BPS, BPF, and TBARS. Associations of bisphenol and TBARS concentrations with endometriosis risk were explored with multivariate logistic and linear regression analyses. Results: After adjustment for urinary creatinine, age, BMI, parity, and residence, endometriosis risk was increased with each 1 log unit of BPA [OR 1.5; 95%CI 1.0–2.3] and Σbisphenols [OR 1.5; 95%CI 0.9–2.3] but was not associated with the presence of BPS and BPF. Classification of the women by tertiles of exposure revealed statistically significant associations between endometriosis risk and the second tertile of exposure to BPA [OR 3.7; 95%CI 1.3–10.3] and Σbisphenols [OR 5.4; 95%CI 1.9–15.6]. In addition, TBARS concentrations showed a close-to-significant relationship with increased endometriosis risk [OR 1.6; 95%CI 1.0–2.8], and classification by TBARS concentration tertile revealed that the association between endometriosis risk and concentrations of BPA [OR 2.0; 95%CI 1.0–4.1] and Σbisphenols [OR 2.2; 95%CI 1.0–4.6] was only statistically significant for women in the highest TBARS tertile (>4.23 μM). Conclusion: Exposure to bisphenols may increase the risk of endometriosis, and oxidative stress may play a crucial role in this association. Further studies are warranted to verify these findings.

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“…Furthermore, endometriosis symptoms are often associated with a significant impairment in psychological wellbeing [15,16], that has also a substantial impact on the quality of life [17,18]. Several different theories have been developed in order to justify the etiopathology of endometriosis; although the theory of retrograde menstruation [19,20], developed by Sampson, was widely accepted several years ago, to date, accumulating evidence suggests a key role of genetics, epigenetics, and immune mechanisms for the onset and progression of the disease [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

Riemma

Laganà

Schiattarella

et al. 2020

IJMS

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Background: Ion channels play a crucial role in many physiological processes. Several subtypes are expressed in the endometrium. Endometriosis is strictly correlated to estrogens and it is evident that expression and functionality of different ion channels are estrogen-dependent, fluctuating between the menstrual phases. However, their relationship with endometriosis is still unclear. Objective: To summarize the available literature data about the role of ion channels in the etiopathogenesis of endometriosis. Methods: A search on PubMed and Medline databases was performed from inception to November 2019. Results: Cystic fibrosis transmembrane conductance regulator (CFTR), transient receptor potentials (TRPs), aquaporins (AQPs), and chloride channel (ClC)-3 expression and activity were analyzed. CFTR expression changed during the menstrual phases and was enhanced in endometriosis samples; its overexpression promoted endometrial cell proliferation, migration, and invasion throughout nuclear factor kappa-light-chain-enhancer of activated B cells-urokinase plasminogen activator receptor (NFκB-uPAR) signaling pathway. No connection between TRPs and the pathogenesis of endometriosis was found. AQP5 activity was estrogen-increased and, through phosphatidylinositol-3-kinase and protein kinase B (PI3K/AKT), helped in vivo implantation of ectopic endometrium. In vitro, AQP9 participated in extracellular signal-regulated kinases/p38 mitogen-activated protein kinase (ERK/p38 MAPK) pathway and helped migration and invasion stimulating matrix metalloproteinase (MMP)2 and MMP9. ClC-3 was also overexpressed in ectopic endometrium and upregulated MMP9. Conclusion: Available evidence suggests a pivotal role of CFTR, AQPs, and ClC-3 in endometriosis etiopathogenesis. However, data obtained are not sufficient to establish a direct role of ion channels in the etiology of the disease. Further studies are needed to clarify this relationship.

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Environmental and occupational exposure to bisphenol A and endometriosis: urinary and peritoneal fluid concentration levels

Abstract: Results highlight the potential association between BPA exposure and endometriosis, as well as the current lack of knowledge regarding occupational exposure to BPA and the need of epidemiological studies focused on single activities/occupations, such as housewives, cleaners, students.

Cited by 63 publications

References 55 publications

Bisphenol A: an emerging threat to female fertility

Bisphenol A: an emerging threat to female fertility

Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study

Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

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