Environmental and occupational chemicals

Jensen, Allan Astrup

doi:10.1016/b978-044481981-9/50028-x

Cited by 3 publications

(2 citation statements)

References 130 publications

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“…The study was community-based, and conducted in a very stable population with a median time of residency exceeding 35 years. BMI and lactation have been shown to be associated with organochlorine concentrations (Rogan et al, 1987;Jensen, 1988;Kelsey et al, 1993). Among controls in our study, neither BMI nor the length of lactation was significantly associated with serum PCBs or organochlorine pesticides levels, and they did not appear to confound the association between organochlorines and risk of breast cancer.…”

Section: Discussionmentioning

confidence: 58%

Case–control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia

Pavúk¹,

Cerhan

Lynch

et al. 2003

J Expo Sci Environ Epidemiol

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This case-control study was designed to investigate association between polychlorinated biphenyls (PCBs) and risk of breast cancer in an area of high environmental exposure in the Michalovce district of eastern Slovakia. Incident breast cancer cases from the Michalovce district diagnosed between May 1997 and May 1999 were recruited through the Oncology Department of the District Hospital. A total of 15 individual PCB congeners, 2,2 0 -bis(4-chlorophenyl)-1,1-dichloroethylene (DDE), 2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (DDT), and hexachlorobenzene (HCB) were measured in the serum of 24 breast cancer patients and 88 population controls in 1998-1999. The median levels of total PCBs were similar in cases (2586 ng/g of lipid) and controls (2682 ng/g of lipid). Higher serum levels (highest vs. lowest tertile) of total PCBs (odds ratio (OR) ¼ 0.42, 95% CI 0.10-1.82, p-for trend ¼ 0.31), group 1 congeners (OR ¼ 0.37, 95% CI 0.10-1.43, P-for trend ¼ 0.02), group 2 congeners (OR ¼ 0.32, 95% CI 0.07-1.56, P-for trend ¼ 0.60), and group 3 congeners (OR ¼ 0.49, 95% CI 0.12-2.04, P-for trend ¼ 0.51) were inversely associated with risk of breast cancer. Higher serum levels of DDE (OR ¼ 3.04, 95% CI 0.65-14.3, P-for trend ¼ 0.10) were positively associated with risk of breast cancer, while there was no association for DDT (OR ¼ 1.19, 95% CI 0.27-5.23, P-for trend ¼ 0.68), and an inverse association for HCB (OR ¼ 0.45, 95% CI 0.06-3.19, P-for trend ¼ 0.67). While generally not statistically significant, PCB and HCB levels were inversely associated with risk of breast cancer in this highly exposed population. DDE, but not DDT, was positively associated with risk.

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Section: Discussionmentioning

confidence: 58%

Case–control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia

Pavúk¹,

Cerhan

Lynch

et al. 2003

J Expo Sci Environ Epidemiol

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“…Su contenido de cloro les confiere poca polaridad, por lo tanto son insolubles en agua; el DDE manifiesta un log K ow 5,83 26 y no se excreta fácilmente por vía urinaria sino que se acumula en el tejido adiposo. En la etapa de lactancia se movilizan a la leche y ésta es la vía preferente de eliminación en los mamíferos femeninos [27][28][29][30][31] .…”

Section: Plaguicidas Organocloradosunclassified

Waste and pollutants in human milk

Flores¹,

Martínez²,

Gonzalo³

et al. 2002

Rev. Esp. Salud Publica

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RESUMENLa contaminación de la leche humana por xenobióticos es un problema generalizado a nivel mundial, que se ve afectado por las variaciones geográficas, climáticas, culturales y socioeconómicas de cada lugar. Las políticas de salud pública han enfrentado la situación mediante una vigilancia sostenida y legislaciones restrictivas con el objeto de reducir los efectos perjudiciales sobre las poblaciones y el ambiente, sin embargo se registran datos objetivables, sobre todo en los países en desarrollo. En esta revisión se destacan aspectos generales y particulares de los residuos y contaminantes organoclorados, organofosforados, antibióticos, metales pesados, bifenilos policlorados, dioxinas y furanos, valores de sus contenidos, efectos tóxicos estudiados y los límites máximos permitidos por las legislaciones internacionales.Palabras clave: Contaminación ambiental. Residuos. Toxicidad. Lactancia. ABSTRACT Waste and Pollutants in Human MilkThe contamination of human milk by xenobiotics is a common problem worldwide which is affected by the geographical, climate-related, cultural and socioeconomic variations in each individual location.Public health policies have dealt with this situation by means of ongoing monitoring and restrictive legislation in order to reduce the damaging effects on the populations and the environment, objectivatable data however being recorded particularly in the developing countries. Overall and individual aspects of waste and contaminating oganochlorines, organophosphorates, antibiotics, polychlorate biphenyls, dioxins and furans, their content values, toxic effects studies and the maximum limits permitted under international legislation are highlighted.

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Screening of Mercury and Persistent Organochlorine Pollutants in Long-Finned Pilot Whale (Globicephala melas) in the Faroe Islands

Dam¹,

Bloch

2000

Marine Pollution Bulletin

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Environmental and occupational chemicals

Cited by 3 publications

References 130 publications

Case–control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia

Case–control study of PCBs, other organochlorines and breast cancer in Eastern Slovakia

Waste and pollutants in human milk

Screening of Mercury and Persistent Organochlorine Pollutants in Long-Finned Pilot Whale (Globicephala melas) in the Faroe Islands

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