Environmental and nuclear influences on microalgal chloroplast gene expression

Carrera-Pacheco, Saskya E.; Hankamer, Ben; Oey, Melanie

doi:10.1016/j.tplants.2023.03.013

Cited by 2 publications

(1 citation statement)

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“…As in plants [267], the algal chloroplast genome affords high-level accumulation of recombinant therapeutics [268][269][270][271] (Figure 5B). The prokaryotic features of the polyploid chloroplast genome (plastome) enable efficient homologous recombination-based transgene insertion and multigene expression with synthetic operons [272].…”

Section: Production Of Heterologous Immunotherapeutics In Microalgaementioning

confidence: 99%

The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics

Cutolo,

Caferri,

Campitiello

et al. 2023

Marine Drugs

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Rheumatoid arthritis (RA) is an invalidating chronic autoimmune disorder characterized by joint inflammation and progressive bone damage. Dietary intervention is an important component in the treatment of RA to mitigate oxidative stress, a major pathogenic driver of the disease. Alongside traditional sources of antioxidants, microalgae—a diverse group of photosynthetic prokaryotes and eukaryotes—are emerging as anti-inflammatory and immunomodulatory food supplements. Several species accumulate therapeutic metabolites—mainly lipids and pigments—which interfere in the pro-inflammatory pathways involved in RA and other chronic inflammatory conditions. The advancement of the clinical uses of microalgae requires the continuous exploration of phytoplankton biodiversity and chemodiversity, followed by the domestication of wild strains into reliable producers of said metabolites. In addition, the tractability of microalgal genomes offers unprecedented possibilities to establish photosynthetic microbes as light-driven biofactories of heterologous immunotherapeutics. Here, we review the evidence-based anti-inflammatory mechanisms of microalgal metabolites and provide a detailed coverage of the genetic engineering strategies to enhance the yields of endogenous compounds and to develop innovative bioproducts.

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