Environmental and Human Microbiome for Health

Panthee, Bimala; Gyawali, Saroj; Panthee, Pratiksha; Techato, Kuaanan

doi:10.3390/life12030456

Cited by 24 publications

(32 citation statements)

References 99 publications

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“…Specifically, indoor microbiota can be shaped according to the diversity and composition of soil and plants by transferring outdoor microbes indoors and adding houseplants to built-in interiors (Roviello et al, 2021). To an increasing extent, studies have shown that the interaction between human and environmental microbiomes affects human health and the prevalence of NCDs (Ahn and Hayes, 2021;Panthee et al, 2022). Roslund et al (2022) investigated the impact of biodiversity on immune tolerance using a double-blind and placebo-controlled intervention trial.…”

Section: Figurementioning

confidence: 99%

Microbiota shaping and bioburden monitoring of indoor antimicrobial surfaces

Mäki

Salonen²,

Kivisaari³

et al. 2023

Front. Built Environ.

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Indoor residents are constantly exposed to dynamic microbiota that have significant health effects. In addition to hand hygiene, cleaning, and disinfection, antimicrobial coatings (AMCs) can prevent the spread of infectious diseases in public areas. The sustainable use of antimicrobial-coated products requires an assessment of their pros and cons for human health and the environment. The toxicity and resistance risks of AMCs have been considered, but large-scale genetic studies on the microbial community compositions and resistomes of AMCs are scarce. The use of an AMC can reduce the total number of microbes on a surface but poses the risk of dysbiosis, microbial imbalance, such as the polarized growth of metallophilic, metal- and antimicrobial-resistant, and other survivor bacteria, and the overall reduction of microbial diversity. Loss of diversity may lead to the enrichment of harmful bacteria and an increased risk of communicable or immunological non-communicable inflammatory diseases (NCDs). In public buildings, such as kindergartens and nursing homes for the elderly, the use of AMCs is likely to increase due to epidemics and pandemics in recent years. Therefore, comprehensive metagenomic research is needed to monitor the effects of AMCs on indoor microbial community compositions and functions. Although the determination of good indoor microbiota and homeostasis is difficult, microbial communities that have health-protective or harmful effects can and should be identified using a metagenomic sequencing approach before the large-scale implementation of AMCs.

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Section: Figurementioning

confidence: 99%

Microbiota shaping and bioburden monitoring of indoor antimicrobial surfaces

Mäki

Salonen²,

Kivisaari³

et al. 2023

Front. Built Environ.

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“…There are abundant microorganisms (known as the microbiota) that live inside the human body and on the skin surface, which far outnumbers the body's somatic cells (Turnbaugh et al, 2007). Human microbes can be divided into three categories-beneficial, pathogenic and opportunistic and they play a vital role in maintaining human health (Panthee et al, 2022). The change of microbial diversity in the human body is related to diseases in various parts of the human body, including the skin, gastrointestinal tract, urinary tract, reproductive tract, and other disease-prone parts (Binek, 2012).…”

Section: Introductionmentioning

confidence: 99%

Urogenital tract and rectal microbiota composition and its influence on reproductive outcomes in infertile patients

Dong

Zhong²,

Zhang³

et al. 2023

Front. Microbiol.

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IntroductionMicrobiota in the human body are closely related to human diseases. Female urogenital tract and rectal microbes have been considered as important factors affecting female pregnancy, but the mechanism is unknown.MethodsCervical, vaginal, urethral, and rectal swabs were collected from 22 infertile patients and 10 controls, and follicular fluid was extracted from 22 infertile patients. The microbial composition of different sampling sites of infertile patients was examined. By comparing the microbial composition difference between infertile patients and controls and combining bioinformatics methods to analyze the potential impact of the female urogenital tract (cervical, vaginal and urethral) and rectal microbial diversity on female infertility and pregnancy outcomes.ResultsLactobacillus predominated in the female urogenital tract, but its abundance decreased in infertile patients, whereas the abundance of Gardnerella and Atopobium increased. The microbial changes in the urethra had the same trend as that in the vagina. Compared with healthy controls, the cervical and rectal microbial diversity of infertile patients were significantly increased and decreased, respectively. There might be interactions between microbes in different parts of female. Geobacillus thermogeniticans was enriched in the urogenital tract and rectum of infertile patients, and has a good predictive effect on infertility. Compared with infertile patients, L. johnsonii was enriched in the vagina, urethra, and intestine of the control group. L. acidophilus in follicular fluid might be associated with Non-pregnancy.ConclusionThis study found that the microbial composition of infertile patients was changed compared with that of healthy people. The translocation of Lactobacillus between the rectum and urogenital tract might play a protective barrier role. The changes of Lactobacillus and Geobacillus might be related to female infertility or pregnancy outcome. The study provided a theoretical basis for the future treatment of female infertility from the perspective of microorganisms by detecting the microbial changes associated with female infertility.

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“…These associations could reflect the direct impacts of environmental microbial exposure on inhabitants' health, as well as through indirect effects of dust microbiota on the human gut, skin, oral, and respiratory microbiomes (6)(7)(8). Housing characteristics and other environmental exposures have been shown to influence indoor microbial communities, including farm-related exposures (8)(9)(10)(11). Living in or near a farm environment entails unique microbial exposures and subsequent health concerns.…”

Section: Introductionmentioning

confidence: 99%

Metagenomics reveals novel microbial signatures of farm exposures in house dust

Wang

Dalton

Lee

et al. 2023

Preprint

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Indoor home dust microbial communities, important contributors to human health outcomes, are shaped by environmental factors, including farm-related exposures. Detection and characterization of microbiota are influenced by sequencing methodology; however, it is unknown if advanced metagenomic whole genome shotgun sequencing (WGS) can detect novel associations between environmental exposures and the indoor built-environment dust microbiome, compared to conventional 16S rRNA amplicon sequencing (16S). This study aimed to better depict indoor dust microbial communities using WGS to investigate novel associations with environmental risk factors from the homes of 781 farmers and farm spouses enrolled in the Agricultural Lung Health Study. We examined various farm-related exposures, including living on a farm, crop versus animal production, and type of animal production, as well as non-farm exposures, including home cleanliness and indoor pets. We assessed the association of the exposures on within-sample alpha diversity and between-sample beta diversity, and the differential abundance of specific microbes by exposure. Results were compared to previous findings using 16S. We found most farm exposures were significantly positively associated with both alpha and beta diversity. Many microbes exhibited differential abundance related to farm exposures, mainly in the phyla Actinobacteria, Bacteroidetes, Firmicutes, and Proteobacteria. The identification of novel differential taxa associated with farming at the genera level, including Rhodococcus, Bifidobacterium, Corynebacterium, and Pseudomonas, was a benefit of WGS compared to 16S. Our findings indicate that characterization of dust microbiota, an important component of the indoor environment relevant to human health, is heavily influenced by sequencing techniques. WGS is a powerful tool to survey the microbial community that provides novel insights on the impact of environmental exposures on indoor dust microbiota, and should be an important consideration in designing future studies in environmental health.

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Environmental and Human Microbiome for Health

Cited by 24 publications

References 99 publications

Microbiota shaping and bioburden monitoring of indoor antimicrobial surfaces

Microbiota shaping and bioburden monitoring of indoor antimicrobial surfaces

Urogenital tract and rectal microbiota composition and its influence on reproductive outcomes in infertile patients

Metagenomics reveals novel microbial signatures of farm exposures in house dust

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