Environmental and human health risks associated with exposure to hazardous elements present in urban dust from Barranquilla, Colombian Caribbean

Osorio‐Martinez, Jorge; Silva, Luis; Flores, Érico M.M.; Nascimento, Mariele S.; Picoloto, Rochele S.; Olívero-Verbel, Jesús

doi:10.1002/jeq2.20200

Cited by 12 publications

(3 citation statements)

References 63 publications

(131 reference statements)

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“…Al powder is used in explosives, fireworks and steel manufacturing. Thus, various sources could expose humans to these common nanoparticles [71][72][73][74][75][76][77][78][79][80][81]. In this study, we used intraperitoneal administration of nanoparticles in spinal nerve lesion model to study their effects on neuropathic pain.…”

Section: Nanoparticles Are Abundant In the Environmentmentioning

confidence: 99%

Cerebrolysin Attenuates Exacerbation of Neuropathic Pain, Blood-spinal Cord Barrier Breakdown and Cord Pathology Following Chronic Intoxication of Engineered Ag, Cu or Al (50–60 nm) Nanoparticles

et al. 2023

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Neuropathic pain is associated with abnormal sensations and/or pain induced by non-painful stimuli, i.e., allodynia causing burning or cold sensation, pinching of pins and needles like feeling, numbness, aching or itching. However, no suitable therapy exists to treat these pain syndromes. Our laboratory explored novel potential therapeutic strategies using a suitable composition of neurotrophic factors and active peptide fragments-Cerebrolysin (Ever Neuro Pharma, Austria) in alleviating neuropathic pain induced spinal cord pathology in a rat model. Neuropathic pain was produced by constrictions of L-5 spinal sensory nerves for 2–10 weeks period. In one group of rats cerebrolysin (2.5 or 5 ml/kg, i.v.) was administered once daily after 2 weeks until sacrifice (4, 8 and 10 weeks). Ag, Cu and Al NPs (50 mg/kg, i.p.) were delivered once daily for 1 week. Pain assessment using mechanical (Von Frey) or thermal (Hot-Plate) nociceptive showed hyperalgesia from 2 weeks until 10 weeks progressively that was exacerbated following Ag, Cu and Al NPs intoxication in nerve lesioned groups. Leakage of Evans blue and radioiodine across the blood-spinal cord barrier (BSCB) is seen from 4 to 10 weeks in the rostral and caudal cord segments associated with edema formation and cell injury. Immunohistochemistry of albumin and GFAP exhibited a close parallelism with BSCB leakage that was aggravated by NPs following nerve lesion. Light microscopy using Nissl stain exhibited profound neuronal damages in the cord. Transmission electron microcopy (TEM) show myelin vesiculation and synaptic damages in the cord that were exacerbated following NPs intoxication. Using ELISA spinal tissue exhibited increased albumin, glial fibrillary acidic protein (GFAP), myelin basic protein (MBP) and heat shock protein (HSP 72kD) upregulation together with cytokines TNF-α, IL-4, IL-6, IL-10 levels in nerve lesion that was exacerbated following NPs intoxication. Cerebrolysin treatment significantly reduced hyperalgesia and attenuated BSCB disruption, edema formation and cellular changes in nerve lesioned group. The levels of cytokines were also restored near normal levels with cerebrolysin treatment. Albumin, GFAP, MABP and HSP were also reduced in cerebrolysin treated group and thwarted neuronal damages, myelin vesiculation and cell injuries. These neuroprotective effects of cerebrolysin with higher doses were also effective in nerve lesioned rats with NPs intoxication. These observations suggest that cerebrolysin actively protects spinal cord pathology and hyperalgesia following nerve lesion and its exacerbation with metal NPs, not reported earlier.

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Section: Nanoparticles Are Abundant In the Environmentmentioning

confidence: 99%

Cerebrolysin Attenuates Exacerbation of Neuropathic Pain, Blood-spinal Cord Barrier Breakdown and Cord Pathology Following Chronic Intoxication of Engineered Ag, Cu or Al (50–60 nm) Nanoparticles

et al. 2023

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“…Noteworthily, non-carcinogenic risks were estimated for all the heavy metals considered in the present study. However, carcinogenic risk assessments were only restricted for Cr, Pb, Cd, Ni, and Co; due to their known carcinogenic potencies in human systems (Osorio-Martinez et al, 2021).…”

Section: Risk Characterizationmentioning

confidence: 99%

“…Where CSF is the cancer slope factor (mg/kg/day) -1 (Gabarrón et al, 2017;USEPA, 2002;Osorio-Martinez et al, 2021). The values for CSF for selected metals for the different routes of exposure are provided by USEPA (USEPA, 2010), depicted in Supplementary Data, Table S4.…”

Section: Cancer Risk Assessmentmentioning

confidence: 99%

Ecotoxicological status and health risks implication of heavy metals in urban soils of the A’koon and Brahabobom communities, Tarkwa – Ghana

Fosu

Gyimah

Boakgye

et al. 2023

Preprint

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Heavy metal contamination of urban soils and it possible detrimental effects to both environmental quality and humans have gained significant attention for decades. However, data on the ecotoxicological status and health implication of heavy metal pollution of soils in Tarkwa remains vague. Herein, nine heavy metals (Cd, Co, Cu, Cr, Fe, Mn, Pb, Ni, and Zn) were analyzed in 20 urban soils, of typical artisanal mining communities in Tarkwa, using Flame Atomic Absorption Spectrophotometer (AAS VARIAN AA240FS). Multivariate statistical analysis as well as ecotoxicological indexes were employed to identify pollution sources of metals and possible ecotoxicological effects, respectively. In addition, non-carcinogenic and carcinogenic risks for residents’ exposure through oral, dermal, and inhalation were estimated. The mean concentrations (mg/kg) of the nine metals followed a decreasing order: Fe > Mn > Zn > Cr > Pb > Cu > Co > Ni > Cd. Results on principal component analysis (PCA) and hierarchical cluster analysis (HCA) were in concomitant revealing that Pb and Cd inputs may be due to anthropogenic influenced whiles the occurrences of Cr, Fe, Co in the soil could be attributed to similar geochemical processes. Noteworthily, 45% of soils samples from the study sites had the total toxic unit (TTU) greater than 4, an indication that the heavy metals may pose deleterious effects on soil-dwelling organisms. For all the exposure routes, the estimated hazard quotients (HQs) for the children, youth, and adult populations were < 1, for all metals. However, hazard index (HI) estimations showed a considerable non-cancer risk to children residents of the A’Koon community via dermal exposure (HI = 1.5). The potential cancer risks associated with daily exposures revealed that children resident of the two communities may be susceptible to Cr via inhalation (> 1 × 10− 4), at a cancer risks of 5.7 × 10− 4 and 4.13 × 10− 4 for the Brahabobom and A’koon communities, respectively.

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Oxidative potential of metal-polluted urban dust as a potential environmental stressor for chronic diseases

Schiavo

Meza-Figueroa

Vizuete-Jaramillo

et al. 2022

Environ Geochem Health

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Environmental and human health risks associated with exposure to hazardous elements present in urban dust from Barranquilla, Colombian Caribbean

Cited by 12 publications

References 63 publications

Cerebrolysin Attenuates Exacerbation of Neuropathic Pain, Blood-spinal Cord Barrier Breakdown and Cord Pathology Following Chronic Intoxication of Engineered Ag, Cu or Al (50–60 nm) Nanoparticles

Cerebrolysin Attenuates Exacerbation of Neuropathic Pain, Blood-spinal Cord Barrier Breakdown and Cord Pathology Following Chronic Intoxication of Engineered Ag, Cu or Al (50–60 nm) Nanoparticles

Ecotoxicological status and health risks implication of heavy metals in urban soils of the A’koon and Brahabobom communities, Tarkwa – Ghana

Oxidative potential of metal-polluted urban dust as a potential environmental stressor for chronic diseases

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