Environmental and genetic determinants of vitamin D status among older adults in London, UK

Jolliffe, David A.; Hanifa, Yasmeen; Witt, Karolina D; Venton, Timothy R; Rowe, Marion; Timms, Philip; Hyppönen, Elina; Walton, Robert; Griffiths, Christopher J.; Martineau, Adrian R.

doi:10.1016/j.jsbmb.2016.01.005

Cited by 34 publications

(20 citation statements)

References 27 publications

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“…For example, in a study of 642 healthy children in Denmark, VDR gene polymorphism was not proven to have any effect on vitamin D levels ( 42 ). Similar results were also obtained in a survey of 222 adults in the UK ( 43 ). It can therefore be assumed that polymorphic variants do not affect the serum level of vitamin D, but can affect its function by changing its binding sites.…”

Section: Discussionsupporting

confidence: 87%

Vitamin D Status in Russian Children and Adolescents: Contribution of Genetic and Exogenous Factors

et al. 2020

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Kondratyeva et al. Exogenous Factors in Vitamin D Results: We found that the blood level of 25(OH)D depended on the geographical location and the number of sunny days per year. The average blood level of 25(OH)D in adolescent boys was statistically significantly lower than in girls of this age group. The level of 25(OH)D also significantly depended on the prophylactic dose of cholecalciferol administered to the subjects. In the study, it was shown that a dose of cholecalciferol ≥1,000 IU per day can achieve a normal level of 25(OH)D in healthy children. We found no statistically significant association between single-nucleotide polymorphic variants of cytochrome P450 genes (CYP2C9 * 3, CYP3A4 * 3, CYP2C9 * 2, CYP2D6 * 4, and CYP3A4 * 1B) and blood level of 25(OH)D in the subjects. We also did not find a relationship between the TaqI, FokI, and BsmI polymorphisms of the VDR gene and serum 25(OH)D concentration. Conclusion: Exogenous factors (time of year, place of residence, and prophylactic administration of cholecalciferol), as well as endogenous factors (age and sex), play a determining role in the development of vitamin D deficiency and insufficiency; in contrast to genetic factors-polymorphic variants of the genes of xenobiotic phase 1 enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A4) and the VDR gene-which do not play such role. This study shows the need to create a diagnostic algorithm for Vitamin D deficiency based on the age, season of the year, and prophylactic dose of cholecalciferol.

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Section: Discussionsupporting

confidence: 87%

Vitamin D Status in Russian Children and Adolescents: Contribution of Genetic and Exogenous Factors

et al. 2020

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“…Still, despite the relatively small sample size there are statistical significant differences between the different tissues, suggesting true effects. It should also be noted that the distribution of the CYP24A1 rs6013897 and the CYP2R1 rs2060793 genotypes follows the same trend as in a previous study [34], indicating that the cohort could be representative for individuals in northern Europe. Another limitation is that we only have data on mRNA-expression and not on protein level.…”

Section: Endocrine Caresupporting

confidence: 75%

Genetic Expression Profile of Vitamin D Metabolizing Enzymes in the First Trimester

2016

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The aim of this study was to map the genetic expression of the vitamin D metabolizing enzymes CYP27A, CYP27B1, CYP2R1, and CYP24A1 in the first trimester in different human fetal tissues. In addition, the gene expression was correlated with fetal age, season, and presence of single nucleotide polymorphisms (SNPs) in the genes encoding CYP27A1 (rs4674344), CYP2R1 (rs2060793), and CYP24A1 (rs6013897). Fetal samples from livers (n=60), kidneys (n=43), lungs (n=37), and intestines (n=14) were analyzed by quantitative PCR. In addition, the expression of the enzymes was also analyzed in adult livers (n=20). The highest expression of CYP2R1 and CYP24A1 was found in fetal kidney and lung. CYP27A1 was expressed at the highest levels in the liver and kidney and CYP27B1 had the highest levels in the kidney. The expression of fetal hepatic CYP2R1 and CYP27A1 was increased during summertime. Carriers of the G-allele of the rs2060793 SNP in the CYP2R1 gene, a genotype previously associated with rickets, had lower levels of CYP2R1 mRNA.In conclusion, this study suggest that the kidneys rather than the liver, may be of importance for fetal vitamin D metabolism, even for the 25-hydroxylation, during the first trimester. The results also suggest that the lungs and intestines are important for vitamin D metabolism in the fetus. Finally, GG- carriers of the rs2060793 SNP had significantly lower CYP2R1 expression and might be at risk for 25-hydroxyvitamin D deficiency.

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“…[ 48 , 54 ]. Associations between the independent variables and 25(OH)D were expected, according to previous research in middle aged and older populations, for: age [ 49 , 54 ], household income [ 69 ], education [ 49 ], residence [ 70 , 71 ], alcoholic beverages consumption [ 53 , 72 ] physical activity [ 55 , 73 ] self-perceived health [ 54 ], supplement intake [ 55 , 74 ] and BMI [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

Association between serum 25-hidroxyvitamin D concentrations and ultraviolet index in Portuguese older adults: a cross-sectional study

et al. 2017

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BackgroundThe older population is a risk group for hypovitaminosis D. The Ultraviolet Index (UVI) can be an indicator of potential for cutaneous synthesis of vitamin D but physiological and other environmental factors also influence vitamin D synthesis and status. Knowledge about vitamin D status in Portuguese older adults is limited. This study aims to explore the association between Ultraviolet Index and serum 25-hidroxyvitamin D3 [25(OH)D] levels accounting for other potential influential factors.MethodsA cross-sectional study was conducted between December 2015 and June 2016, in 1497 Portuguese older adults (≥ 65 years) within Nutrition UP 65 project. For each participant, serum 25(OH)D was determined and the mean UVI (mUVI) in the respective residence district was calculated for the previous 30 days. Stepwise linear regression analyses were conducted for the following periods of blood collection: between December and June, December and March and April and June. Standardized regression coefficients (Sβ) and 95% confidence intervals were calculated.ResultsThe median 25(OH)D concentration was 35.9 nmol/L. The UVI was independently and positively associated with 25(OH)D in the models for December–June (Sβ = 0.244, 95% CI: 0.198; 0.291, P < 0.001) and April–June (Sβ = 0.295, 95% CI: 0.299; 0.362, P < 0.001) and independently and negatively associated in December–March period (Sβ = −0.149, 95% CI: -0.211; −0.087, P < 0.001).ConclusionsIn this sample with high vitamin D deficiency frequency, the UVI was a predictor of 25(OH)D levels but the direction of the association varied according to the blood collection period. Our results suggest that accounting for the time of year in future research regarding vitamin status and related public health recommendations may be relevant.Electronic supplementary materialThe online version of this article (10.1186/s12877-017-0644-8) contains supplementary material, which is available to authorized users.

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Environmental and genetic determinants of vitamin D status among older adults in London, UK

Cited by 34 publications

References 27 publications

Vitamin D Status in Russian Children and Adolescents: Contribution of Genetic and Exogenous Factors

Vitamin D Status in Russian Children and Adolescents: Contribution of Genetic and Exogenous Factors

Genetic Expression Profile of Vitamin D Metabolizing Enzymes in the First Trimester

Association between serum 25-hidroxyvitamin D concentrations and ultraviolet index in Portuguese older adults: a cross-sectional study

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