Environment-wide association study on childhood obesity in the U.S.

Uche, Uloma Igara; Suzuki, Sumihiro; Fulda, Kimberly; Zhou, Zhengyang

doi:10.1016/j.envres.2020.110109

Cited by 13 publications

(13 citation statements)

References 114 publications

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“…In this study, we not only confirmed established risk factors, such as maternal second-hand smoking, but also identified several factors not reported or not examined in previous EWAS in western countries (8,9), such as ASB consumption and soymilk intake. The comparison with RCTs or MR studies support a role of dairy intake, binge eating and possibly earlier puberty, suggesting these factors or their drivers (for example, sex hormones as the drivers of age at puberty) might be considered as potential targets for intervention.…”

Section: Discussionsupporting

confidence: 83%

“…Environment-wide association studies (EWAS) enable us to assess a variety of exposures across the human environmental exposome in a high-throughput manner (5), similar to genome wide association studies for genetic associations. Previous EWAS have been successfully performed on outcomes, such as type 2 diabetes (6), cardiovascular disease (7), and childhood obesity in western settings (8, 9) but not in a Chinese setting. In the previous EWAS of childhood adiposity in the US (6-17 years old), UK and Europe (6-11 years old), second-hand smoking was related to higher childhood BMI, whilst some other exposures, such as vitamins, were not consistently associated with adiposity in these settings (8, 9).…”

Section: Introductionmentioning

confidence: 99%

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Environment-wide and epigenome-wide association study of adiposity in “Children of 1997” birth cohort

Zhao

Fan

Huang

et al. 2022

Preprint

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Background: Increasing childhood adiposity is a global issue requiring potentially local solutions to ensure it does not continue into adulthood. We systematically identified potentially modifiable targets of adiposity at the onset and end of puberty in Hong Kong the most economically developed major Chinese city. Methods:We conducted an environment-wide association study (EWAS) and an epigenome-wide association study of adiposity to systematically assess associations with body mass index (BMI) and waist-hip ratio (WHR) in Hong Kong's population-representative "Children of 1997" birth cohort.Univariable linear regression was used to select exposures related to adiposity at ~11.5 years (BMI n≤7,119, WHR n=5,691) and ~17.6 years (n = 3,618) at Bonferroni-corrected significance, and multivariable linear regression to adjust for potential confounders followed by replication (n=308) and CpG by CpG analysis (n=286) at ~23 years. Findings were compared with evidence from randomized controlled trials (RCTs) and Mendelian randomization (MR) studies.Results: At ~11.5 and ~17.6 years the EWAS identified 14 and 37 exposures associated with BMI, as well as seven and 12 associated with WHR respectively. Most exposures had directionally consistent associations at ~23 years. Maternal second-hand smoking, maternal weight, and birth weight were consistently associated with adiposity. Diet (including dairy intake and artificially sweetened beverages), physical activity, snoring, binge eating, and earlier puberty were positively associated with BMI at ~17.6 years, while eating before sleep was inversely associated with BMI at ~17.6 years. Findings for birth weight, dairy intake, binge eating, and possibly earlier puberty are consistent with available evidence from RCTs or MR studies We found 21 CpGs related to BMI and 18 to WHR. Conclusions:These novel insights into potentially modifiable factors associated with adiposity at the outset and the end of puberty could, if causal, inform future interventions to improve population health in Hong Kong and similar Chinese settings..

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Environment-wide and epigenome-wide association study of adiposity in “Children of 1997” birth cohort

Zhao

Fan

Huang

et al. 2022

Preprint

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“…The ExWAS approach was firstly used to explore the association of numerous nutrition and environmental factors with various health outcomes in adults, such as abdominal obesity 19 , blood pressure 20 , diabetes mellitus 15 and telomere length 21 . The application of ExWAS in studying excess weight in younger age groups is still limited to a single study investigating the association between polycyclic aromatic hydrocarbons with childhood obesity among 6–17 years participants using data from the 1999–2016 National Health and Nutrition Examination Survey (NHANES) waves 22 .…”

Section: Introductionmentioning

confidence: 99%

An exposome-wide association study on body mass index in adolescents using the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and 2013–2014 data

Haddad

Andrianou

Parrish

et al. 2022

Sci Rep

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Excess weight is a public health challenge affecting millions worldwide, including younger age groups. The human exposome concept presents a novel opportunity to comprehensively characterize all non-genetic disease determinants at susceptible time windows. This study aimed to describe the association between multiple lifestyle and clinical exposures and body mass index (BMI) in adolescents using the exposome framework. We conducted an exposome-wide association (ExWAS) study using U.S. National Health and Nutrition Examination Survey (NHANES) 2003–2004 wave for discovery of associations between study population characteristics and zBMI, and used the 2013–2014 wave to replicate analysis. We included non-diabetic and non-pregnant adolescents aged 12–18 years. We performed univariable and multivariable linear regression analysis adjusted for age, sex, race/ethnicity, household smoking, and income to poverty ratio, and corrected for false-discovery rate (FDR). A total of 1899 and 1224 participants were eligible from 2003–2004 and 2013–2014 survey waves. Weighted proportions of overweight were 18.4% and 18.5% whereas those for obese were 18.1% and 20.6% in 2003–2004 and 2013–2014, respectively. Retained exposure agents included 75 laboratory (clinical and biomarkers of environmental chemical exposures) and 64 lifestyle (63 dietary and 1 physical activity) variables. After FDR correction, univariable regression identified 27 and 12 predictors in discovery and replication datasets, respectively, while multivariable regression identified 22 and 9 predictors in discovery and replication datasets, respectively. Six were significant in both datasets: alanine aminotransferase, gamma glutamyl transferase, segmented neutrophils number, triglycerides; uric acid and white blood cell count. In this ExWAS study using NHANES data, we described associations between zBMI, nutritional, clinical and environmental factors in adolescents. Future studies are warranted to investigate the role of the identified predictors as early-stage biomarkers of increased BMI and associated pathologies among adolescents and to replicate findings to other populations.

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“…Recent studies have researched obesity in relation to specific drugs or drug types [ 12 – 16 ]. There have also been recent studies that examined various aspects of obesity such as childhood obesity [ 16 , 17 ], obesity and hours spent at work [ 18 ], exposure to certain pollutants or chemicals [ 19 – 21 ], trends in obesity [ 22 ], and obesity and waist circumference [ 23 ]. However, there have not been any studies that look at overall RXD use in individuals with obesity.…”

Section: Introductionmentioning

confidence: 99%

Assessing the use of prescription drugs and dietary supplements in obese respondents in the National Health and Nutrition Examination Survey

et al. 2022

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Introduction Obesity is a common disease and a known risk factor for many other conditions such as hypertension, type 2 diabetes, and cancer. Treatment options for obesity include lifestyle changes, pharmacotherapy, and surgical interventions such as bariatric surgery. In this study, we examine the use of prescription drugs and dietary supplements by the individuals with obesity. Methods We conducted a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) data 2003–2018. We used multivariate logistic regression to analyze the correlations of demographics and obesity status with the use of prescription drugs and dietary supplement use. We also built machine learning models to classify prescription drug and dietary supplement use using demographic data and obesity status. Results Individuals with obesity are more likely to take cardiovascular agents (OR = 2.095, 95% CI 1.989–2.207) and metabolic agents (OR = 1.658, 95% CI 1.573–1.748) than individuals without obesity. Gender, age, race, poverty income ratio, and insurance status are significantly correlated with dietary supplement use. The best performing model for classifying prescription drug use had the accuracy of 74.3% and the AUROC of 0.82. The best performing model for classifying dietary supplement use had the accuracy of 65.3% and the AUROC of 0.71. Conclusions This study can inform clinical practice and patient education of the use of prescription drugs and dietary supplements and their correlation with obesity.

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Environment-wide association study on childhood obesity in the U.S.

Cited by 13 publications

References 114 publications

Environment-wide and epigenome-wide association study of adiposity in “Children of 1997” birth cohort

Environment-wide and epigenome-wide association study of adiposity in “Children of 1997” birth cohort

An exposome-wide association study on body mass index in adolescents using the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and 2013–2014 data

Assessing the use of prescription drugs and dietary supplements in obese respondents in the National Health and Nutrition Examination Survey

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