Environment Friendly Synthesis of <i>N</i>′-(1,3-Diphenylallylidene)-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazides: Crystal Structure and Their Anti-oxidant Potential

Abstract

An environment friendly synthesis of novel hybrid pharmacophores derived from synergism of nalidixic acid and 1,3-diphenylprop-2-en-1-ones is described. Percent yield and reaction times of microwave assisted reactions have been compared with the reactions carried out under conventional reaction conditions which show marked decrease in reaction times and significant increase in yields. Besides, anti-oxidant potential of the synthesized hybrid compounds was evaluated and some of the compounds showed marked ascorbic acid equivalence Ferric reducing anti-oxidant power (FRAP) and metal chelating capacities. Crystal study of one representative of the synthesized series is also presented.

The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery

“…Figure 8A reports the green synthetic step used for the preparation of the product, where microwave irradiation was used to increase the yield and decrease the reaction time. To assess the sustainability of the protocol, metrics of atom economy, carbon efficiencies and reaction mass efficiency were calculated, as well as energy consumption data ( Mubarak et al, 2019 ). Kalluraya and co-workers reported a regioselective synthesis of spiropyrrolidine derivatives in a comparative study in which microwave-assisted reactions afforded the best results in facilitating the condensation of starting materials and afterwards in the formation of the final regioselective cycloadducts ( Figure 8B ).…”