Environment as therapy: neuroscience for intellectual disability and dementia

Sansevero, Gabriele; Sale, Alessandro

doi:10.18632/oncotarget.14602

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Mice were tested in two different motor tasks, i.e., grip strength and grid walk. Each animal performed all the tests before the GL261 injection (baseline measurement) and 3,5,7,9,12,15,17,19, and 21 days after the tumor implant [27]. To exclude any influence of circadian rhythms on behavior, all tests were performed during the same time interval each day (2:00-5:00 p.m., light phase).…”

Section: Motor Testsmentioning

confidence: 99%

“…Voluntary physical exercise is among the components of the well-known paradigm of environmental enrichment (EE), a very effective strategy to restore plasticity and elicit recovery from different neurodevelopmental disorders [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. EE is known to profoundly affect the central nervous system (CNS) at the functional, anatomical, and molecular levels, both during the critical period and adulthood [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Voluntary Physical Exercise Reduces Motor Dysfunction and Hampers Tumor Cell Proliferation in a Mouse Model of Glioma

Tantillo

Colistra

Baroncelli

et al. 2020

IJERPH

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Currently, high-grade gliomas are the most difficult brain cancers to treat and all the approved experimental treatments do not offer long-term benefits regarding symptom improvement. Epidemiological studies indicate that exercise decreases the risk of brain cancer mortality, but a direct relationship between physical exercise and glioma progression has not been established so far. Here, we exploited a mouse model of high-grade glioma to directly test the impact of voluntary physical exercise on the tumor proliferation and motor capabilities of affected animals. We report that exposing symptomatic, glioma-bearing mice to running wheels (i) reduced the proliferation rate of tumors implanted in the motor cortex and (ii) delayed glioma-induced motor dysfunction. Thus, voluntary physical exercise might represent a supportive intervention that complements existing neuro-oncologic therapies, contributing to the preservation of functional motor ability and counteracting the detrimental effects of glioma on behavioral output.

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Section: Motor Testsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Voluntary Physical Exercise Reduces Motor Dysfunction and Hampers Tumor Cell Proliferation in a Mouse Model of Glioma

Tantillo

Colistra

Baroncelli

et al. 2020

IJERPH

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“…Copyright  Redolat R multidimensional perspective [56][57][58]. Recently, it has been proposed a more holistic approach to the treatment of Alzheimer's disease and other neurodegenerative diseases [29].…”

Section: Gr Up Smmentioning

confidence: 99%

Towards a more Comprehensive Approach to Non-Pharmacological Therapies for Alzheimer’s Disease and other Dementias

Redolat¹,

Fernández-Ríos²

2019

SM Gerontol Geriatr Res

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The significant rise in life expectancy and the growing ageing of the world's population are accompanied by an increase in the prevalence of neurodegenerative diseases. These disorders have a multidimensional impact on the quality of life for both patients and their caregivers and constitute a major challenge for social protection systems. Alzheimer's Disease (AD) represents an increasing burden for patients, their caregivers and the society. For that reason, it is necessary to assess all the factors involved in the disease pathogenesis of AD in order to address a more comprehensive approach to the management of the disease. In the absence of diseasemodifying pharmacological treatments, interest for in non-pharmacological therapies has recently increased as a complement to other types of interventions in people with AD and other dementias. Non-pharmacological interventions for behavioral and psychological symptoms in dementia patients should take into account the caring environment as well as the support and education of the caregivers. Individualized and person-centered models tailored to the tastes and preferences of each patient could offer better results than the more traditional ones. Information and communication technologies can also provide assistance to people with dementia and to their caregivers. We can conclude that there is a need for developing pharmacological and non-pharmacological treatments aimed to different therapeutic targets and that can be applied in the early stages of the disease development. A more comprehensive approach to the management of AD and an increasing interest in dementia prevention could contribute to the development of new therapeutic strategies. These interventions are expected to have positive impact on the quality of life of people with AD and their caregivers.Recently the classification system for AD has changed again [14] and this new research framework, based more in neuropathological changes than in clinical symptoms, will influence new approaches to the treatment since is expected to be accompanied by an earlier identification of at-risk patients [15,16]. It is necessary to assess all the factors involved in the disease pathogenesis of AD in order to address a more comprehensive approach to the search of new pharmacological treatments and the development of non-pharmacological therapies for the management of behavioral and psychological symptoms [17,18]. Some authors suggest that it would be necessary to reach a better knowledge of all the processes underlying biological ageing in order to develop new therapeutic

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“…Post-synaptic density protein 95 (PSD-95) has a fundamental role in the organization of the signal transduction apparatus at synapses, and it is therefore of special relevance in plasticity, i.e., learning and memory formation [23]. It shows complex variation patterns in aging and in neuropathologies, but, for example, it has been found to increase in rodents exposed to an enriched environment [24], a promising strategy to mitigate cognitive decline and Alzheimer's disease dysfunctions [25]. Mitochondria are deeply involved in neuronal plasticity [26] and neurogenesis [27], providing ATP for processes involved in neurite outgrowth.…”

Section: Introductionmentioning

confidence: 99%