Enucleation in Asian Indian patients: a histopathological review of 2009 cases

Kaliki, Swathi; Jajapuram, Sai Divya; Bejjanki, Kavya Madhuri; Ramappa, George; Mohamed, Ashik; Mishra, Dilip Kumar

doi:10.1038/s41433-018-0226-9

Cited by 6 publications

(9 citation statements)

References 26 publications

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“…In contrast to previous studies [6,7,9], our data showed a slight predominance of females undergoing enucleation, compared to males (51.4% vs. 48.6%). Trauma as a primary enucleation indication was more common among male than female patients (67.4% vs. 32.6%), similar to the findings of de Gottrau et al (79% vs. 21%) [3], Freitag (75% vs. 25%) [10], and Cheng (81.3% vs. 18.7%) [4].…”

Section: Discussioncontrasting

confidence: 99%

“…Furthermore, the number of enucleations with tumours did not decrease over time in the literature [9, 12]; a similar result was observed in our series (Figure 4) [15,16]. Similar to the findings of our study, tumours were also reported as the leading causes of enucleation in France [17], Turkey [8], and India [7] in 1996, 1997, and 2018, respectively.…”

Section: Discussionsupporting

confidence: 90%

“…In our study, the most common tumours were uveal MM among adults and RB in children, similar to the reports from China [4], Denmark [13], Germany [3], Iceland [9], Iran [18], and India [7]. The ratio of RB to MM was 1 : 5.5, which is similar to previous findings in our geographical region (France: 1 : 2 [17]; Poland: 1 : 13 [11]); notably, it contrasts with the ratios reported in Asia (China: 1.43 : 1 [4]; India: 7.3 : 1 [7]). It has been suggested that closer to Equator, MM has a lower prevalence, whereas RB has a higher prevalence [4].…”

Section: Discussionsupporting

confidence: 90%

“…The peak incidence of enucleation in Hungary (between 0–5 and 51–85 years) occurred in a similar age group among pediatric patients to that reported in China (between 0–10 and 31–40 years) [4] or in India (between 0 and 10 years) [6, 7] and in a similar age group among adult patients to that reported in Germany (between 61 and 75 years) [3]. In Hungary, in more than 82% of cases, enucleations were performed in subjects older than 30 years, while in India [6, 7] and Turkey [8], 82–84% and 54% of enucleations, respectively, were performed in subjects below 30 years of age.…”

Section: Discussionmentioning

confidence: 72%

“…There have been several clinicopathological studies on indications for enucleation, but these surveys are not current or were published in developing countries [3–7]. The order of primary clinical enucleation indications varies among different countries.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological Review of 547 Bulbar Enucleations in Hungary (2006–2017)

Tóth

Szentmáry

Sándor

et al. 2019

Journal of Ophthalmology

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Purpose. To analyse current clinicopathological enucleation indications in a large third-referral centre in a developed country (Hungary) over a period of 12 years. Methods. Retrospective review was performed on 547 enucleated eyes of 543 patients (48.6% males, age 52.7 ± 24.5 years) who were operated on between 2006 and 2017 at the Department of Ophthalmology of Semmelweis University, in Budapest, Hungary. For each subject, clinicopathological data, including patient demographics, indications for enucleation, B-scan ultrasound reports, operative details, and histopathological analyses, were reviewed. Primary enucleation indications were classified into trauma, tumours, systemic diseases, surgical diseases, infections or inflammations, miscellaneous diseases, and unclassifiable groups. Clinical immediate enucleation indications were classified as tumours, atrophia or phthisis bulbi, infection or inflammation, painful blind eye due to glaucoma, acute trauma, threatening or spontaneous perforation, cosmetic causes, and expulsive bleeding. Results. The most common primary enucleation indications were tumours (47.3%), trauma (16.8%), surgical diseases (15.7%), infection or inflammation (11.6%), systemic diseases (5.1%), miscellaneous diseases (2.0%), and unclassifiable diseases (1.5%). Clinical immediate enucleation indications were tumours (46.1%), atrophia or phthisis bulbi (18.5%), infection or inflammation (18.5%), painful blind eye due to glaucoma (11.2%), acute trauma (3.7%), threatening or spontaneous perforation (1.3%), cosmetic reasons (0.5%), and expulsive bleeding (0.4%). Conclusions. Intraocular tumours represent the most common clinicopathological indication for ocular enucleation in our study population. Following ocular trauma and systemic diseases, the rate of enucleation decreased in the last decade, compared to those previously reported in other developed countries. However, changes were not observed for surgical diseases, infectious and inflammatory causes, or for miscellaneous and unclassified diseases. Orbital implant financing should be increased to ensure better postoperative aesthetic rehabilitation, following enucleation in Hungary.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

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Clinicopathological Review of 547 Bulbar Enucleations in Hungary (2006–2017)

Tóth

Szentmáry

Sándor

et al. 2019

Journal of Ophthalmology

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Changing indications for enucleation and selected unusual pathologies

Thaung

2019

Saudi Journal of Ophthalmology

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PurposeTo survey clinical indications for enucleations received within a single specialist ophthalmic pathology department over a 21-year period.MethodsCases were identified from the departmental records and categorised by indication type as well as by year.ResultsOver time, there has been a decreasing trend in eyes removed for end-stage indications such as phthisis, blindness or pain, as well as a decrease in eyes removed following trauma.ConclusionWith the reducing number of eyes removed for end-stage disease and trauma, the majority of enucleations performed are now for malignancy. However, eyes are still removed for other indications. A selection of rarer pathologies is presented.

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Clinical Review of Ocular Traumas Resulting in Enucleation or Evisceration in a Tertiary Eye Care Center in Hungary

Tóth

Pluzsik

Csákány

et al. 2021

Journal of Ophthalmology

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Purpose. To analyse the demographic and clinical characteristics of ocular traumas resulting in enucleation/evisceration in a large tertiary referral center in a developed country (Hungary) over a period of 15 years. Patients and Methods. A retrospective review of enucleated/eviscerated eyes that underwent surgery between 2006 and 2020 at the Department of Ophthalmology of Semmelweis University, Budapest, Hungary, due to ocular trauma as the primary indication for enucleation/evisceration. For each subject, clinical history, B-scan ultrasound report, and histopathology results were reviewed. Results. There were 124 enucleated/eviscerated eyes from 124 patients (91 males (73.4%)). The mean age at the time of trauma was 37.3 ± 26.0 years while the mean age at the time of enucleation/evisceration was 46.9 ± 20.3 years. The main clinical diagnoses after ocular trauma were open globe injury (n = 96; 77.4%), ocular burns (n = 6; 4.8%), traumatic optic neuropathy (n = 4; 3.2%), bulbar avulsion (n = 3; 2.4%), traumatic cataract (n = 2; 1.6%), retinal ablation (n = 1; 0.8%), and traumatic carotid-cavernous fistula (n = 1; 0.8%). Among the 124 patients, 98 (79.0%) underwent enucleation and 26 (21.0%) evisceration. Patients who underwent primary enucleation/evisceration (n = 24 19.4%) were significantly older at the time of the injury (57.7 ± 22.7 years) than people who underwent secondary eye removal (32.4 ± 24.4 years) ( p < 0.0001 ). The mean time interval between trauma and enucleation/evisceration was 114.9 ± 163.5 months. The main clinical indications for anophthalmic surgery were atrophia/phthisis bulbi (n = 56, 45.2%), acute trauma (n = 25, 20.2%), painful blind eye due to glaucoma (n = 17, 13.7%), endophthalmitis (n = 10, 8.1%), and cosmetic reasons (n = 7, 5.6%). One patient (0.8%) had sympathetic ophthalmia. Conclusions. Primary enucleation/evisceration was performed in one-fifth of all ocular trauma-related anophthalmic surgeries in our tertiary eye care center with enucleation being the most common procedure. Atrophia/phthisis bulbi was the most frequent immediate clinical indication for enucleation/evisceration.

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Enucleation in Asian Indian patients: a histopathological review of 2009 cases

Cited by 6 publications

References 26 publications

Clinicopathological Review of 547 Bulbar Enucleations in Hungary (2006–2017)

Clinicopathological Review of 547 Bulbar Enucleations in Hungary (2006–2017)

Changing indications for enucleation and selected unusual pathologies

Clinical Review of Ocular Traumas Resulting in Enucleation or Evisceration in a Tertiary Eye Care Center in Hungary

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