Entwicklungsarbeiten auf dem Arsen‐Gebiet

Abstract

Entwicklung und Wirkung d e r wesentlichen Heilmittel aus den Gruppen der Arsonsauren, heterocyclischen Arsenverbindungen, Anenobenzole und Arsenoxyde werden zusammengefalh. Offensichtlich mussen die Substanzen zunachst auf dem Krankheitserreger fixiert werden, urn wirken zu konnen. Welche Reaktionen dann im einzelnen ablaufen, ist noch nicht vollig geklart. Es encheint gesichert, dal3 die Sulfhydryl-Gruppen d e r Zellproteine die Arsenoceptoren darstellen. Die Funktion der gleichfalls fiir die Wirkung entscheidenden Substituenten (Seitenketten) ist noch nicht zu ubersehen, und man ist bei der Entwicklung neuer Praparate daher noch irnmer weitgehend auf Ernpirie angewiesen.

The structure and reactivity of arsenic compounds: Biological activity and drug design

“…His contribution to the field has been enumerated by a number of authors including Bauer [215], Albert [6], Schwyzer [216], and Holmstedt et al [217]. Later developments in the area describing the results of antisyphilitic and anti-nagana testing of several compounds synthesised by the German company H6chst have been outlined [7]. Nowadays these drugs have generally been superseded in the clinic by antibiotics, although a derivative of one of the earlier compounds, melarsoprol, is still used in advanced cases of sleeping sickness, Fig.…”

“…is reported [4,5] to have recommended the use of a paste of realgar, As,, $4, for the treatment of ulcers. In this century the most extensive use of arsenic compounds has been in the treatment of syphilis and trypanosomal diseases [3,6,7], although a variety of other conditions have been treated with As compounds including asthma, diabetes, and skin diseases [4] and until the 1950s [8], arsenic containing preparations were used as so-called tonics, e.g. Fowler's solution [9], reportedly first used by Fowler in 1786 [10-1.…”