Entwicklung von Empfehlungen zum Management von Arzneimitteltherapie bei Multimorbidität

Grandt, Daniel; Gamstätter, Thomas; Fölsch, Ulrich R.

doi:10.1055/a-1234-9684

Cited by 4 publications

(3 citation statements)

References 28 publications

(27 reference statements)

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“…Individuals with comorbid conditions have more hospitalizations, greater functional decline, and increased mortality rates [ 4 , 5 , 6 ]. Co-/multimorbidity poses many challenges for clinical management, e.g., due to multi-drug therapy and possible drug-disease and drug-drug interactions [ 1 , 7 , 8 , 9 ]. Comorbidity is associated with increased health care costs [ 10 ] and challenges the organization of (specialized) healthcare delivery [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Comorbidity Combinations in the Swedish Population

et al. 2022

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High comorbidity rates, especially mental–physical comorbidity, constitute an increasing health care burden, with women and men being differentially affected. To gain an overview of comorbidity rates stratified by sex across a range of different conditions, this study examines comorbidity patterns within and between cardiovascular, pulmonary, skin, endocrine, digestive, urogenital, musculoskeletal, neurological diseases, and psychiatric conditions. Self-report data from the LifeGene cohort of 31,825 participants from the general Swedish population (62.5% female, 18–84 years) were analyzed. Pairwise comorbidity rates of 54 self-reported conditions in women and men and adjusted odds ratios (ORs) for their comparison were calculated. Overall, the rate of pairwise disease combinations with significant comorbidity was higher in women than men (14.36% vs. 9.40%). Among psychiatric conditions, this rate was considerably high, with 41.76% in women and 39.01% in men. The highest percentages of elevated mental–physical comorbidity in women were found for musculoskeletal diseases (21.43%), digestive diseases (20.71%), and skin diseases (13.39%); in men, for musculoskeletal diseases (14.29%), neurological diseases (11.22%), and digestive diseases (10%). Implications include the need for integrating mental and physical health care services and a shift from a disease-centered to an individualized, patient-centered focus in clinical care.

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Section: Introductionmentioning

confidence: 99%

Sex Differences in Comorbidity Combinations in the Swedish Population

et al. 2022

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“…The risk for gastrointestinal bleeding is increased compared to monotherapy with only one drug group [4]. To minimize the risk for gastric ulcer and stomach bleeding during treatment with these drugs, the prophylactic co-prescribing of PPI or other antiulcer drugs is recommended [5].…”

Section: Dear Editormentioning

confidence: 99%

“…In addition to the examples mentioned, there are further constellations where indicated PPI prescribing should be checked [5]. The strength of the study lies in the database covering about 12% of all statutory health-insured persons in Germany (9 million persons).…”

Section: Dear Editormentioning

confidence: 99%