Entry Points for Catheter Placement in Convection-Enhanced Delivery – A Retrospective Anatomic Analysis

Dörner, Lutz; Nabavi, Arya; Hm, Mehdorn

doi:10.1055/s-0029-1243259

Cited by 1 publication

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“…Multiple CED injections might be required to reach the periphery and the infiltrative area of tumor. Other factors such as the safety and feasibility of treating the peritumoral area of the brain [41], the entry points for catheter placement [42] should be considered.…”

Section: Discussionmentioning

confidence: 99%

Convection-enhancement delivery of platinum-based drugs and LipoplatinTM to optimize the concomitant effect with radiotherapy in F98 glioma rat model

et al. 2015

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The prognosis for patients with glioblastoma remains poor with current treatments. Although platinum based drugs are sometimes offered at relapse, their efficacy in this setting is still disputed. In this study, we use convection-enhanced delivery (CED) to deliver the platinum-based drugs (cisplatin, carboplatin, and Lipoplatin ™ -liposomal formulation of cisplatin) directly into the tumor of F98 glioma-bearing rats that were subsequently treated with γ radiation (15 Gy). CED increased by factors varying between 17 and 111, the concentration of these platinum-based drugs in the brain tumor compared to intra-venous (i.v.) administration, and by 9-to 34-fold, when compared to intra-arterial (i.a.) administration. Furthermore, CED resulted in a better systemic tolerance to platinum drugs compared to their i.a. injection. Among the drugs tested, carboplatin showed the highest maximum tolerated dose (MTD). Treatment with carboplatin resulted in the best median survival time (MeST) (38.5 days), which was further increased by the addition of radiotherapy (54.0 days). Although the DNA-bound platinum adduct were higher at 4 h after CED than 24 h for carboplatin group, combination with radiotherapy led to similar improvement of median survival time. However, less toxicity was observed in animals irradiated 24 h after CEDbased chemotherapy. In conclusion, CED increased the accumulation of platinum drugs in tumor, reduced the toxicity, and resulted in a higher median survival time. The best treatment was obtained in animals treated with carboplatin and irradiated 24 h later.

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Section: Discussionmentioning

confidence: 99%

Convection-enhancement delivery of platinum-based drugs and LipoplatinTM to optimize the concomitant effect with radiotherapy in F98 glioma rat model

et al. 2015

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Entry Points for Catheter Placement in Convection-Enhanced Delivery – A Retrospective Anatomic Analysis

Abstract: Inserting CED catheter via the described entry points will presumably save time in planning and reduce side effects.

Cited by 1 publication

References 13 publications

Convection-enhancement delivery of platinum-based drugs and LipoplatinTM to optimize the concomitant effect with radiotherapy in F98 glioma rat model

Convection-enhancement delivery of platinum-based drugs and LipoplatinTM to optimize the concomitant effect with radiotherapy in F98 glioma rat model

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