Entropy monitoring decreases isoflurane concentration and recovery time in pediatric day care surgery -a randomized controlled trial

Abstract

In pediatric day care surgery, entropy monitoring resulted in statistically though not clinically significant faster awakening and significantly lower end – tidal isoflurane concentrations.

Clinical effectiveness and cost-effectiveness of depth of anaesthesia monitoring (E-Entropy, Bispectral Index and Narcotrend): a systematic review and economic evaluation

“…Risk of bias because of random sequence generation was considered low in four of the trials, in which sequences were generated either by computer 56,57,61 or by drawing lots. 62 Risk of bias because of random sequence generation was deemed unclear in the remaining three trials, which provided no information on the method of sequence generation.…”

“…[54][55][56][57] Anaesthetists who administered anaesthesia according to standard clinical monitoring were blinded to E-Entropy values. However, none of the studies unequivocally reported that study participants and personnel were blinded to the study groups.…”

“…56 Two trials were considered at high risk of attrition bias because the rate of attrition was ≥10% in at least one of the study arms, and not balanced across the arms. 58,62 The remaining two trials were judged to have unclear risk of attrition bias because of incomplete outcome data, either because attrition was not reported at all 55 or it was not reported separately by study arm.…”

“…One of the E-Entropy trials 56 reported that no external funding was used, and one trial 62 did not report whether or how the work was funded. Two trials were funded by non-commercial sponsors, which were a university 54 and a national science organisation.…”

“…In the four E-Entropy trials that were not supported by the E-Entropy device manufacturer, three did not refer to conflict of interests 54,58,62 and one stated that no conflicts were disclosed. 56 The seven E-Entropy studies were published during 2005 to 2010 and ranged in their total sample size from 50 to 335 patients. [54][55][56][57][58]61,62 Five of the trials involved a two-arm comparison of E-Entropy against standard clinical monitoring.…”