In this paper, entropy generation rate in the flow of couple stress fluid undergoing exothermic chemical reaction through a porous vertical channel is studied by applying the second law of thermodynamics. A semi-analytical solution for the governing equations is obtained using Adomian decomposition method (ADM). The effects of couple stress parameter, internal heat generation parameter, Dufour number on the velocity, temperature distribution, entropy generation rate and Bejan number are investigated and the results were presented graphically. The results show that solutal diffusivity has significant effect on the entropy generation rate and irreversibility of heat in a couple stress fluid flow.