Entrapment and release of saquinavir using novel cationic solid lipid nanoparticles

Solid lipid nanoparticles for ocular drug delivery

“…Mehnert and Mäder (2001) classified these methods into four categories; namely high shear homogenization and ultrasound (Hou et al, 2003), high pressure (hot and cold homogenization) (zur Mühlen et al, 1998;Mehnert & Mäder, 2001;Olbrich et al, 2001;Radomska-Soukharev, 2007;Helgason et al, 2009), solvent emulsification/evaporation, and microemulsion-based SLNs preparation (Mehnert & Mäder, 2001;Heydenreich et al, 2003;Vighi et al, 2007;Kuo & Chen, 2009). In addition to the previous methods, SLNs composed of glyceryl monostearate (GMS) can be successfully prepared by a solvent emulsification-diffusion technique (Trotta et al, 2003) or by a double emulsion technique (Lv et al, 2009).…”

“…Characterization of structure and quality is a very important step in determining stability and release kinetics of SLNs. A number of methods have been employed to measure SLN particle size and morphology, amongst them photon correlation spectroscopy (PCS) (Mehnert & Mäder, 2001;Olbrich et al, 2001;Hu et al, 2002;Kuo & Chen, 2009;Lv et al, 2009), atomic force microscopy (AFM) (Olbrich et al, 2001;Vighi et al, 2007), transmission electron microscopy (TEM) (Hou et al, 2003;Trotta et al, 2003;Lv et al, 2009), and fieldflow-fractionation (FFF) being the most popular. Zeta potential measurement is equally important in order to predict stability of colloidal dispersions.…”

“…Sometimes ultracentrifugation for a period of time is solely sufficient to separate SLNs from the aqueous phase (Kuo & Chen, 2009). The amount of drug present in the aqueous continuous phase can be determined by a sensitive method like HPLC or UV spectroscopy.…”

Exploring the Nanotechnology-Based Drug Delivery Systems for AIDS Treatment

“…SLN were fabricated via a microemulsion method and stabilized by polysorbate 80; in addition, the lipid phase contained cationic stearylamine, dioctadecyldimethyl ammonium bromide, non-ionic Compritol 888 ATO and cacao butter. The in vitro drug release assay suggested that the carriers could sustain drug delivery without an apparent initial burst (Kuo & Chen, 2009). Aji Alex et al (2010) investigated the use of SLNs to target intestinal lymphatic vessels.…”

“…In addition to surfactant systems, polymeric nanoparticles have been extensively studied as nanometric carriers, and these carriers presenting different morphologies, including nanospheres or nanocapsules. In this document, these are referred to as polymeric nanoparticles (Mainardes et al, 2010;Sharma & Garg, 2010, Schäfer et al, 1992, Shah & Amiji, 2006, Destache et al, 2009, Mahajan et al, 2009) and solid lipid nanoparticles (Aji Alex et al, 2010;Kuo & Chen, 2009;Shegokara et al, 2010). The advantages and limitations of each system are discussed, thus, this work can be used as a start point for researchers focusing on nanotechnologybased drug delivery systems for the treatment of AIDS.…”