Entrapment and release difference resulting from hydrogen bonding interactions in niosome

Formulation of Span 80 niosomes modified with SDS for lactic acid entrapment

“…Cholesterol increased the lactic acid entrapment efficiency, niosome size, and the zeta potential absolute value, which varied from 6%, 181 nm, and −25 mV in formulations without cholesterol (experiment 5) to 12%, 260 nm, and −61 mV in the 10 mol/m 3 cholesterol formulation (experiment 7), respectively. These results are in agreement with those obtained by other researchers for the entrapment of hydrophilic solutes in niosomes, such as calcein [1,18], salicylic acid [3], mannitol [37], cromolyn sodium [38], and atenolol [39].…”

“…(2014) [1][2][3][4][5][6][7][8][9][10][11][12][13] www.deswater.com doi: 10.1080/19443994.2014.993726 attractiveness of these vesicles for industrial production [10,11]. Encapsulation efficiency depends on several factors such as the type of structure (multilamellar, unilamellar, or multivesicular), the length of the hydrophobic group of surfactant forming the bilayer, the nature and size of the hydrophilic head, pH and composition of the formulation medium, and the nature of the solute (hydrophobicity, polarity, molecular weight, and structure).…”

“…Niosomes, like liposomes, are able to encapsulate both hydrophobic and hydrophilic compounds inside their core and in the bilayer, respectively. Nevertheless, from a technical point of view, niosomes are preferred because of their greater chemical stability, high purity, low cost, content uniformity, and their easy handling and storage, which overcome the drawbacks associated with liposomes [1][2][3][4]. Another advantage is the simple method for the large-scale production of niosomes without the use of unacceptable solvents, so they are widely used in pharmaceutical, cosmetic, and, to a lesser extent, food applications [5][6][7][8][9].…”

Uptake and transport of insulin across intestinal membrane model using trimethyl chitosan coated insulin niosomes

“…In specific time interval, 0.2 ml of supernatant release medium was collected and replaced by freshly prepared buffer. The individual samples were centrifuged at 25,000 rpm for 10 min and the insulin concentration was measured by previously described ELISA [7,42]. All the experiments were performed in triplicate.…”

Novel non-ionic surfactant proniosomes for transdermal delivery of lacidipine: optimization using 23factorial design andin vivoevaluation in rabbits

“…On increasing the amount of lecithin added, a significant decrease in %EE was observed. Hao & Li (2011) found that the number of niosomes taking part in encapsulation decreases as increasing the lipid concentration, which might be ascribed to the aggregate of niosomes at high lipid level. Similar results were also obtained by Xu et al (2009) of lecithin was too high, the entrapment efficiency would decrease.…”