Entrance surface dose and induced DNA damage in blood lymphocytes of patients exposed to low-dose and low-dose-rate X-irradiation during diagnostic and therapeutic interventional radiology procedures

Basheerudeen, Safa Abdul Syed; Kanagaraj, Karthik; Jose, M.T.; Ozhimuthu, Annalakshmi; Paneerselvam, S.; Pattan, Sudha; Joseph, Santhosh; Raavi, Venkateswarlu; Prakash, Venkatachalam

doi:10.1016/j.mrgentox.2017.04.001

Cited by 19 publications

(4 citation statements)

References 36 publications

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Section: Introductionmentioning

confidence: 99%

“…3 The increasing use of ionizing radiation (IR) in medical diagnosis and treatment has raised concerns about its potential long-term effects on human health, as prolonged exposure to low-dose radiation has been found to cause adverse health effects including genomic instability and cancer. 4,5 Given this, recent years has seen increased interest in understanding the biological effects of chronic low-dose radiation exposure and its relationship to genomic instability. 6 This work has shown that occupational radiation exposure leads to increased genomic instability; however, little information is available regarding the effects and possible mechanisms of low-dose radiation over a protracted period of time.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China

Fang

et al. 2019

Dose-Response

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The increasing use of ionizing radiation (IR) in medical diagnosis and treatment has caused considerable concern regarding the effects of occupational exposure on human health. Despite this concern, little information is available regarding possible effects and the mechanism behind chronic low-dose irradiation. The present study assessed potential genomic damage in workers occupationally exposed to low-dose X-rays. A variety of analyses were conducted, including assessing the level of DNA damage and chromosomal aberrations (CA) as well as cytokinesis-block micronucleus (CBMN) assay, gene expression profiling, and antioxidant level determination. Here, we report that the level of DNA damage, CA, and CBMN were all significantly increased. Moreover, the gene expression and antioxidant activities were changed in the peripheral blood of men exposed to low-dose X-rays. Collectively, our findings indicated a strong correlation between genomic instability and duration of low-dose IR exposure. Our data also revealed the DNA damage repair and antioxidative mechanisms which could result in the observed genomic instability in health-care workers exposed to chronic low-dose IR.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China

Fang

et al. 2019

Dose-Response

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“…Like any radioactive modality, concerns about risks are always relevant but data in the literature corroborate that the benefits of using radioactive material outweighs its risks (Kunjachan et al., 2015 ; Simonetti et al., 2019 ). Similarly, imaging modalities like CT procedures that may induce DNA damage are used when the benefits outweigh the risks (Dos Santos et al., 2017 ; Helal-Neto et al., 2019 ; Basheerudeen et al., 2017 ; International Society for Pharmacoeconomics and Outcomes Research Rare Disease Special Interest Group, 2015 ). The use of radioactive polymeric nanoparticles may also improve efficacy, leading to a higher targeting in tissues/organs (Bolzati et al., 2012 ; Banerjee et al., 2017 ), which decreases the dose used (including the radioactive dose) and consequently reduces the risk.…”

Section: Discussionmentioning

confidence: 99%

Radioactive polymeric nanoparticles for biomedical application

Wu¹,

Helal-Neto

Matos

et al. 2020

Drug Delivery

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Nowadays, emerging radiolabeled nanosystems are revolutionizing medicine in terms of diagnostics, treatment, and theranostics. These radionuclides include polymeric nanoparticles (NPs), liposomal carriers, dendrimers, magnetic iron oxide NPs, silica NPs, carbon nanotubes, and inorganic metal-based nanoformulations. Between these nano-platforms, polymeric NPs have gained attention in the biomedical field due to their excellent properties, such as their surface to mass ratio, quantum properties, biodegradability, low toxicity, and ability to absorb and carry other molecules. In addition, NPs are capable of carrying high payloads of radionuclides which can be used for diagnostic, treatment, and theranostics depending on the radioactive material linked. The radiolabeling process of nanoparticles can be performed by direct or indirect labeling process. In both cases, the most appropriate must be selected in order to keep the targeting properties as preserved as possible. In addition, radionuclide therapy has the advantage of delivering a highly concentrated absorbed dose to the targeted tissue while sparing the surrounding healthy tissues. Said another way, radioactive polymeric NPs represent a promising prospect in the treatment and diagnostics of cardiovascular diseases such as cardiac ischemia, infectious diseases such as tuberculosis, and other type of cancer cells or tumors.

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“…Rest, physiotherapy and other conservative therapies help in relieving these orthopedic disorders. 16,17 Interventional Cardiologists' working in the cardiac catheterization labs and doing PCI's frequently are exposed to high levels of radiation, which may increase their cancer risk as compared to those cardiologists who are not working in the catheterization labs. 18 In this study, it was observed that the mean duration of working in cardiac catheterization labs was 17.92±4.57 years.…”

Section: Disscussionmentioning

confidence: 99%

Prevalence of Brain and Neck Neoplasms among Interventional Cardiologists; A Multicenter Study

Tariq

Samore²,

Rashid³

et al. 2022

PAFMJ

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Objective: To determine the prevalence of brain and neck neoplasms among Interventional Cardiologists. Study Design: Analytical Cross-sectional study. Place and Duration of Study: Department of Cardiology/Interventional Cardiology of two Tertiary Cardiac Care Centers of Rawalpindi and Lahore Pakistan from Mar 2021 to Apr2022. Methodology: By using the non-probability, consecutive sampling technique, fifty Interventional Cardiologists’ (n=50) of both genders between 35-75 years of age, working in the cardiac catheterization labs for more than 10-years are enrolled after their informed consents. The data was collected from the interviews of Interventional cardiologists, from the shared medical records and also from the family members and colleagues. The Interventional cardiologists were enquired about any neurological signs and symptoms particularly in relation to the head and neck malignancy and also asked about undergoing any CT/MRI or PET scan of head and neck region in the past or recent time. Descriptive statistics for data was computed byusing the SPSS version-25. Results: The mean age of the Interventional Cardiologists of tertiary cardiac care center of Rawalpindi was 50.40±7.77years while of Lahore was 49.16±8.89 years. There were 47(94.0%) males and 03(6.0%) females, from both the Institutes. The mean duration of working in cardiac catheterization labs was 17.92±4.57 years. The head and neck neoplasm’s among Interventional Cardiologists was observed in 01(2%) case. Conclusion: The research study concluded that the prevalence of head and neck neoplasms among Interventional Cardiologists is very low (2%). But still it is the need of hour to be more careful about radiation exposure among the Interventional Cardiologists working for long hours in the cardiac catheterization labs, to lessen down the chances of head and neck malignancy.

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Entrance surface dose and induced DNA damage in blood lymphocytes of patients exposed to low-dose and low-dose-rate X-irradiation during diagnostic and therapeutic interventional radiology procedures

Cited by 19 publications

References 36 publications

Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China

Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China

Radioactive polymeric nanoparticles for biomedical application

Prevalence of Brain and Neck Neoplasms among Interventional Cardiologists; A Multicenter Study

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