Entrainment and synchronization of brain oscillations to auditory stimulations

Henao, David; Navarrete, Miguel; Valderrama, Mario; Quyen, Michel Le Van

doi:10.1016/j.neures.2020.03.004

Cited by 18 publications

(7 citation statements)

References 71 publications

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“…Stephens and colleagues 15 demonstrate that regional differences in the brain’s INT, as indexed in their study by the power spectrum, are related to the temporal structure of the external information, with the former aligning to the latter: (I) regions with shorter INT and faster dynamics, i.e., early auditory cortex, are activated during shorter stimulus segments (e.g., single phonemes or words) (see also refs. 89 – 91 for more support in terms of entrainment); (II) regions with intermediate timescales and balanced slow–fast dynamics, i.e., superior temporal gyrus and inferior frontal gyrus, are recruited by intermediate durations in the temporal structure of stimuli (e.g., the structure of sentences); and (III) regions with longer intrinsic timescales and slower dynamics, i.e., precuneus and medial prefrontal cortex, are activated by slowly varying stimulus dynamics (e.g., stimulus narrative, see also refs. 1 , 15 , 26 , 27 , 36 ).…”

Section: Part Ii: Input Processing Through Intrinsic Neural Timescalesmentioning

confidence: 99%

The brain and its time: intrinsic neural timescales are key for input processing

et al. 2021

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We process and integrate multiple timescales into one meaningful whole. Recent evidence suggests that the brain displays a complex multiscale temporal organization. Different regions exhibit different timescales as described by the concept of intrinsic neural timescales (INT); however, their function and neural mechanisms remains unclear. We review recent literature on INT and propose that they are key for input processing. Specifically, they are shared across different species, i.e., input sharing. This suggests a role of INT in encoding inputs through matching the inputs’ stochastics with the ongoing temporal statistics of the brain’s neural activity, i.e., input encoding. Following simulation and empirical data, we point out input integration versus segregation and input sampling as key temporal mechanisms of input processing. This deeply grounds the brain within its environmental and evolutionary context. It carries major implications in understanding mental features and psychiatric disorders, as well as going beyond the brain in integrating timescales into artificial intelligence.

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Section: Part Ii: Input Processing Through Intrinsic Neural Timescalesmentioning

confidence: 99%

The brain and its time: intrinsic neural timescales are key for input processing

et al. 2021

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“…By fully considering the variability in the phase and latency of the generated neural oscillations (15) , TMS-induced oscillations allow to increase the sensitivity of detecting stroke-related changes in brain dynamics. Last, induced oscillations are known to reflect higher-order processing (76, 77) , which is of particular importance when studying poststroke recovery. Thus, the analysis of TMS-induced oscillations in the present study explained the observed variability in motor recovery of fine motor tasks, such as the nine-hole peg and box and blocks tests, which rely on higher-order motor processes, such as grasping and manipulation, that engage complex motor networks distributed among motor, premotor and parietal cortices, among others (78) .…”

Section: Discussionmentioning

confidence: 99%

Brain oscillatory modes as a proxy of stroke recovery

harquel¹,

Hummel

2023

Preprint

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Stroke is the leading cause of long-term disability, making the search for successful rehabilitation treatment one of the most important public health issues. A better understanding of the neural mechanisms underlying impairment and recovery and the development of associated markers is critical for tailoring treatments to each individual patient with the ultimate goal of maximizing therapeutic outcomes. Here, we used a novel and powerful method consisting of combined transcranial magnetic stimulation (TMS) and multichannel electroencephalography (EEG) to analyze TMS-induced brain oscillations in a large cohort of 60 stroke patients from the acute to the early-chronic phase after a stroke. A data-driven parallel factor analysis (PARAFAC) approach to tensor decomposition allowed to detect brain oscillatory modes specifically centered on the θ, α and β frequency bands. In the acute stage, patients presented a general slowdown of these oscillatory modes, highlighting stroke-induced perturbations within thalamocortical processing. Furthermore, low-frequency modes evolved across stroke stages, according to the extent of motor recovery, associated with changes in GABAergic intracortical inhibition. Overall, these longitudinal changes provide novel insights into the ongoing functional reorganization of brain networks after a stroke and the underlying mechanisms. Notably, we propose that the observed α-mode decrease corresponds to a beneficial disinhibition phase between the subacute and early-chronic stages that fosters structural and functional plasticity and facilitates recovery. Monitoring this phenomenon at the individual patient level will provide critical information for phenotyping patients, developing electrophysiological biomarkers and refining therapies based on personalized excitatory/inhibitory neuromodulation using noninvasive or invasive brain stimulation techniques.

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“…To our knowledge, this is the first RCT in adult burn patients using a live MAR protocol specifically focusing on entrainment. From other studies it is known that neuronal network oscillations can be entrained by external auditory stimuli and may enhance cognitive and motor function or sleep quality for example ( 59 ). Thus, one of the aims of the exploratory part of this study including EEG, EMG, and ECG measurements, is to further explain and/or uncover the basic mechanisms of live and entrained music as a potential stimulus that may help adult burn patients regulate their pain perception.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Music Therapy on Perceived Pain, Mental Health, Vital Signs, and Medication Usage of Burn Patients Hospitalized in the Intensive Care Unit: A Randomized Controlled Feasibility Study Protocol

et al. 2021

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Background: Burn patients experience major physiological and psychological stressors during treatment and rehabilitation, including elevated levels of pain, anxiety, stress, or depression. Music interventions inclusive of music therapy (MT) have been shown to improve such symptoms, but rigorous clinical trials investigating specific music therapy methods in adult burn patients are scarce.Methods: This is a single center Randomized Controlled Trial (RCT) protocol with two parallel arms. Participants are 81 adult burn patients admitted to the Intensive Care Unit (ICU) of the University Hospital Fundación Santa Fe de Bogotá in Colombia. The intervention consists of a Music Assisted Relaxation (MAR) protocol, a music therapy technique composed of entrained live music combined with a guided relaxation and/or the use of imagery. The effects of the MAR will be compared to a control group (treatment as usual) over a period of maximum 2 weeks or six interventions. The primary outcome measure is perceived background pain, as measured with a Visual Analog Scale (VAS) before and after each intervention. Secondary outcomes are anxiety and depression levels; vital signs; and the use of pain medication. Additionally, some patients in the intervention group will be invited to participate in electroencephalography, electromyography, and electrocardiography recordings during the MAR.Discussion: This study protocol follows the SPIRIT guidelines for defining items of clinical trials and is the first study in Colombia to evaluate the effects of music therapy for adult burn patients. With this RCT it is hoped to gather new knowledge about the potential of music therapy to help critical care patients cope and recover from their injuries during the hospitalization in the ICU.Trial registration:www.clinicaltrials.gov, Identifier: NCT04571255.Protocol version: V1.0, May 24th 2021

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Entrainment and synchronization of brain oscillations to auditory stimulations

Cited by 18 publications

References 71 publications

The brain and its time: intrinsic neural timescales are key for input processing

The brain and its time: intrinsic neural timescales are key for input processing

Brain oscillatory modes as a proxy of stroke recovery

The Effect of Music Therapy on Perceived Pain, Mental Health, Vital Signs, and Medication Usage of Burn Patients Hospitalized in the Intensive Care Unit: A Randomized Controlled Feasibility Study Protocol

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