Entosis implicates a new role for P53 in microcephaly pathogenesis, beyond apoptosis
Noelle A. Sterling,
Seo‐Hee Cho,
Seonhee Kim
Abstract:Entosis, a form of cell cannibalism, is a newly discovered pathogenic mechanism leading to the development of small brains, termed microcephaly, in which P53 activation was found to play a major role. Microcephaly with entosis, found in Pals1 mutant mice, displays P53 activation that promotes entosis and apoptotic cell death. This previously unappreciated pathogenic mechanism represents a novel cellular dynamic in dividing cortical progenitors which is responsible for cell loss. To date, various recent models … Show more
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