Entosis and Cell Cycle in Tumor Cell Culture

Kisurina-Evgenieva, O. P.; Khashba, L. A.; Mamichev, I. A.; Savitskaya, M. A.; Онищенко, Г. Е.

doi:10.1134/s1990519x19010073

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…The association of entosis with cancer progression could be explained by the hypothesis that it has a dual role—while entosis can lead to cell death, it can also promote cell survival [ 32 ]. Moreover, it was recently shown in vitro that both inner and outer entotic cells could synthesize DNA (BrdU incorporation) and enter mitosis during entosis [ 33 ]. At present, it is not clear what factor(s) determine whether entosis will lead to cell survival or cell death.…”

Section: Entosis In Cancermentioning

confidence: 99%

Entosis: From Cell Biology to Clinical Cancer Pathology

Młynarczuk-Biały

Dziuba²,

Sarnecka

et al. 2020

Cancers

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Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown. Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence. Finally, we highlight the potential relationship of cell adhesion with entosis in vitro, based on the model of the BxPc3 cells cultured in full adhesive conditions, comparing them to a commonly used MCF7 semiadhesive model of entosis.

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Section: Entosis In Cancermentioning

confidence: 99%

Entosis: From Cell Biology to Clinical Cancer Pathology

Młynarczuk-Biały

Dziuba²,

Sarnecka

et al. 2020

Cancers

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An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis

Sterling

Park

et al. 2023

Nat Commun

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Entosis is cell cannibalism utilized by tumor cells to engulf live neighboring cells for pro- or anti-tumorigenic purposes. It is unknown whether this extraordinary cellular event can be pathogenic in other diseases such as microcephaly, a condition characterized by a smaller than normal brain at birth. We find that mice mutant for the human microcephaly-causing gene Pals1, which exhibit diminished cortices due to massive cell death, also exhibit nuclei enveloped by plasma membranes inside of dividing cells. These cell-in-cell (CIC) structures represent a dynamic process accompanied by lengthened mitosis and cytokinesis abnormalities. As shown in tumor cells, ROCK inhibition completely abrogates CIC structures and restores the normal length of mitosis. Moreover, genetic elimination of Trp53 produces a remarkable rescue of cortical size along with substantial reductions of CIC structures and cell death. These results provide a novel pathogenic mechanism by which microcephaly is produced through entotic cell cannibalism.

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