Entomophthoromycosis in India—a 4‐year study

Krishnan, Srivilliputtur G. Santhana; Sentamilselvi, G; Kamalam, A.; Das, Kishore; Janaki, C

doi:10.1111/j.1439-0507.1998.tb00377.x

Cited by 48 publications

(41 citation statements)

References 3 publications

(1 reference statement)

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“…The limiting factors of oral KI include the following: (1) gastric intolerance, (2) thyroid metabolic disturbances, and (3) drug hypersensitivity. However, oral KI (40 mg/kg daily) for 4-6 wk has been successful in some cases of facial conidiobolomycosis (Kamalam and Thambiah 1982;Nazir et al 1997;Krishnan et al 1998).…”

Section: Managementmentioning

confidence: 99%

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Human Fungal Pathogens of Mucorales and Entomophthorales

Mendoza

Vilela

Voelz

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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In recent years, we have seen an increase in the number of immunocompromised cohorts as a result of infections and/or medical conditions, which has resulted in an increased incidence of fungal infections. Although rare, the incidence of infections caused by fungi belonging to basal fungal lineages is also continuously increasing. Basal fungal lineages diverged at an early point during the evolution of the fungal lineage, in which, in a simplified four-phylum fungal kingdom, Zygomycota and Chytridiomycota belong to the basal fungi, distinguishing them from Ascomycota and Basidiomycota. Currently there are no known human infections caused by fungi in Chytridiomycota; only Zygomycotan fungi are known to infect humans. Hence, infections caused by zygomycetes have been called zygomycosis, and the term "zygomycosis" is often used as a synonym for "mucormycosis." In the four-phylum fungal kingdom system, Zygomycota is classified mainly based on morphology, including the ability to form coenocytic (aseptated) hyphae and zygospores (sexual spores). In the Zygomycota, there are 10 known orders, two of which, the Mucorales and Entomophthorales, contain species that can infect humans, and the infection has historically been known as zygomyEditors:

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Section: Managementmentioning

confidence: 99%

“…infection, resulting in some success. Complete cure of the infection had been achieved in some patients, mostly those with early diagnosis (Kelly et al 1980;Nazir et al 1997;Krishnan et al 1998;Gugnani 1999).…”

Section: Managementmentioning

confidence: 99%

Human Fungal Pathogens of Mucorales and Entomophthorales

Mendoza

Vilela

Voelz

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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“…En pacientes diabéticos y en personas con inmunosupresión existe predisposición a la enfermedad, que se puede diseminar y ser fatal (21)(22)(23). En el manejo de la enfermedad se han empleado diversos agentes con resultados satisfactorios, entre ellos, yoduro de potasio, sulfas, ketoconazol, fluconazol e itraconazol (1,(9)(10)(11)(12)14,19,24).…”

Section: Discussionunclassified

Conidiobolomicosis: hallazgos histopatológicos.

Pérez

Correa²,

Fuentes³

et al. 2004

biomedica

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La conidiobolomicosis es una micosis subcutánea que se localiza generalmente en la línea media facial; es causada por un hongo saprófito de suelos y vegetales secos, propio de regiones intertropicales, que afecta principalmente a hombres adultos. El agente etiológico Conidiobolus coronatus pertenece a la clase de los Zigomicetos, orden Entomoftorales; se caracteriza por hifas cortas y gruesas, generalmente aseptadas, que crece entre 30°C y 37°C y produce granulomas nasales. Se informan a continuación los hallazgos histológicos de un caso de conidiobolomicosis en un paciente de 31 años de raza negra, natural y procedente de la región de Urabá, quien presentaba deformidad mediofacial con edema de nariz, labio superior e imágenes polipoides en senos maxilares con destrucción del tabique nasal. La biopsia demostró inflamación granulomatosa necrosante difusa en la dermis profunda e hipodermis asociada con eosinófilos y fenómeno de Splendore-Hoeppli, en cuya zona central se ubicaban espacios aparentemente vacíos que contenían el hongo que no se tiñó con HE, pero que sí lo hizo con las coloraciones de PAS y Grocott lo cual permitió la observación de hifas de paredes gruesas y rígidas, con torsión central y extremos cónicos.Palabras clave: conidiobolomicosis, Conidiobolus coronatus, micosis subcutáneas, entomoftoromicosis, rinoentomoftoromicosis, cigomicosis. Conidiobolomycosis: a case report with histophathologic findingsConidiobolomycosis is a subcutaneous mycosis of the facial midline affecting primarily adult males. It is caused by the saprophytic fungus, Conodiobolus coronatus, present in soils and dried vegetables, characteristic of intertropical regions. C. coronatus belongs to the class Zygomycetes, order Entomophthorales; it is a fungus composed of thick, short hyphae that grows at temperatures between 30°C and 37°C and causes nasal granulomas. The histologic findings are described of a case of conidiobolomycosis in a 31-year-old male, born and resident in the Urabá region of Colombia. He presented with a mid-facial deformity of the nose and upper lip edema, and polypoid images in the maxillary sinuses with destruction of the nasal septum. The biopsy revealed a diffuse inflammatory lesion located in the deep dermis and in the hypodermis corresponding to a necrotizing granuloma. Associated eosinophils and the presence of the Splendore-Hoeppli phenomenon were noted in the vacant central zone which apparently corresponded to location of the fungal hyphae. They did not stain with HE stain, but reacted to the PAS and Grocott staining techniques and appeared as rigid, thick-walled hyphae, centrally twisted and with cone-shaped endings.

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“…Conidiobolus spp. typically cause a chronic, indolent infection restricted to the nasal mucosa and face and characterized by polyps or palpable subcutaneous masses (Foss et al, 1996;Krishnan et al, 1998). Despite its indolent nature, Walsh et al reported an angioinvasive infection due to Conidiobolus spp.…”

mentioning

confidence: 98%

“…Basidiobolomycosis is a chronic infection of the subcutaneous tissue that mainly involves the thighs, buttocks, or trunks (Krishnan et al, 1998). Conidiobolus spp.…”

mentioning

confidence: 99%