Entomophthoromycosis Caused by Conidiobolus coronatus: Clinicomycological Study Of a Case

Mukhopadhyay, D.; Ghosh, L. M.; Thammayya, A; Sanyal, Mithu M.

doi:10.1016/s0385-8146(12)80113-1

Cited by 15 publications

(16 citation statements)

References 2 publications

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“…This investigator (184) explored the possibility of snuff-taking as a contributing factor but did not isolate Conidiobolus from any of the tobacco samples studied in his laboratory. Mukhopadhyay et al (312) reported a case of sinusitis zygomycosis caused by C. coronatus in a 72-year-old Brazilian woman with a history of chewing tobacco leaves, pond bathing, and cattle raising, suggesting that other possible contributing factors should be addressed.…”

Section: Conidiobolus Speciesmentioning

confidence: 99%

“…The majority of infections have been limited to tropical areas, particularly the African rain forest (184), but cases have been reported worldwide (283,389), including Nigeria (87,165,183,283,336,345), Congo (71,283), Zaire (282), Cameroon (82,165,283,378), Côte d'Ivoire (132,165), Central Africa (71,165,283,458), India (165,283,312), Brazil (16,43,99,466), Jamaica (57), Costa Rica (416), Columbia (165), Puerto Rico (165), Thailand (63), Malaysia (323), and the United States (136,165,239,319,486,487).…”

Section: Conidiobolus Speciesmentioning

confidence: 99%

“…Infection in the pharynx and larynx, causing dysphagia and obstruction of the larynx, as well as extensive and chronic lymphedema, has been reported (184,282,337). Sinusitis zygomycosis with C. coronatus has been reported worldwide in patients considered to be physiologically and immunologically competent, with different lengths of illness and varying success with treatments (99,312,323,416,454,466). Disseminated infections, including those with fatal outcomes, have been reported with C. coronatus in both immunocompetent and immunocompromised hosts.…”

Section: Conidiobolus Speciesmentioning

confidence: 99%

See 2 more Smart Citations

Zygomycetes in Human Disease

Ribes¹,

Vanover-Sams²,

Baker³

2000

Clinical Microbiology Reviews

1,092

1,053

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Section: Conidiobolus Speciesmentioning

confidence: 99%

Section: Conidiobolus Speciesmentioning

confidence: 99%

Section: Conidiobolus Speciesmentioning

confidence: 99%

See 1 more Smart Citation

Zygomycetes in Human Disease

Ribes¹,

Vanover-Sams²,

Baker³

2000

Clinical Microbiology Reviews

1,092

1,053

View full text Add to dashboard Cite

“…A entomoftoromicose causada por C. coronatus é infecção rara e cujo acometimento rinofacial foi primeiramente descrito em 1965 6 . Acomete principalmente lavradores masculinos, entre 40-60 anos de idade 3 .…”

Section: Discussionunclassified

Entomoftoromicose (zigomicose) causada por Conidiobolus coronatus em Mato Grosso (Brasil): relato de caso

Tadano

Paim

Hueb

et al. 2005

Rev. Soc. Bras. Med. Trop.

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RESUMOEsses fungos são comumente encontrados no solo e nas folhas secas do chão, sendo a infecção decorrente da implantação de esporos inalados, juntamente com partículas do solo, sobre a mucosa nasal. Sabe-se que in vitro o fungo é capaz de produzir várias enzimas tais como elastases, esterases, colagenases e lípases, as quais podem estar envolvidas na patogênese da infecção 3 . A entomoftoromicose causada por C. coronatus manifesta-se clinicamente como um infiltração granulomatosa crônica da mucosa nasal, estendendo-se para o tecido subcutâneo e pele da face contígua, sem delimitação de seu crescimento. Essa expansão tumoral produz sintomas como obstrução nasal e dor local, sendo freqüente a sinusite bacteriana, conseqüente ao processo obstrutivo presente. Chama a atenção, entretanto, a grande freqüência de deformidade facial, resultante de infiltração e edema da região 3 4 . O diagnóstico é geralmente confirmado por cultura e pela visualização microscópica do fungo em material obtido da lesão. Histopatologicamente, a doença se caracteriza por infiltrado granulomatoso do tecido subcutâneo, contendo material eosinofílico hialino, no qual são visualizadas hifas grandes, não septadas (ou raramente septadas) de C. coronatus 4 .Descreve-se aqui o primeiro caso de zigomicose nasofacial causada por C. coronatus em Mato Grosso. RELATO DO CASOJASF, 37 anos, pedreiro, residente em Sinop-MT, desde 1978. Relatou trauma facial com fratura de osso nasal em 1992. Há 2 anos vem apresentando obstrução nasal e epistaxe discreta e esporádica. Evoluiu com aumento progressivo de nódulos subcutâneos duros e pouco dolorosos no dorso do nariz e nas regiões paranasal e frontal. Durante esse período, foi submetido a exaustivo processo de investigação, incluindo biópsia da lesão em região infra-orbitária direita, com diagnóstico de processo inflamatório crônico granulomatoso tipo corpo estranho; porém sem conclusão etiológica. Recebeu vários tipos de tratamento empíricos, sem contudo apresentar melhora. Recentemente,

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“…The diagnosis was made on the basis of the autopsy findings; there were silver-positive and PAS-positive hyphal structures within associated Splendore-Hoeppli phenomena and marked eosinophil infiltration with necrosis, histological findings nearly unique for B. ranarum in human tissue (7,13,14). The only organisms in the histologic differential are Conidiobolus coronatus, Conidiobolus incongruus, and Pythium insidiosum, organisms that are associated with head and neck disease in humans or pleuropericarditis in immunosuppressed patients; however, these microorganisms would be equally rare as a cause of disseminated disease in immunocompetent subjects (4,8,15,19).…”

Section: Case Reportmentioning

confidence: 99%

Disseminated Basidiobolomycosis in an Immunocompetent Woman

Bigliazzi¹,

Poletti²,

Dell'Amore³

et al. 2004

J Clin Microbiol

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Basidiobolomycosis is a chronic subcutaneous infection of the trunk and limbs due to Basidiobolus ranarum.The disease is well known in tropical areas, although recent cases of gastrointestinal basidiobolomycosis have also been reported in Arizona. We describe a young immunocompetent women who had presented with eosinophilia and lung infiltrates. She subsequently died, and diagnosis of disseminated basidiobolomycosis was made on the basis of histological features at autopsy. CASE REPORTA nonsmoking, 40-year-old housewife was admitted to the hospital with sudden acute dyspnea and hypotension; she died a few minutes after admission to the emergency room due to cardiorespiratory arrest.Three days before, the patient noted the appearance of shortness of breath; hard subcutaneous and painless swellings localized to the back of the shoulders and arms were also noted. For 4 months she had been monitored as an outpatient with low-grade fever and increasing eosinophilia (white cell counts were 13.800 and then 28.280; eosinophils, 11% and then 30%), an elevated erythrocyte sedimentation rate (43 mm/h) and C-reactive protein (3.9 mg/dl), and increased immunoglobulin E (2,583 kU/liter). At that time, pulmonary function tests documented airflow obstruction and chest radiographs revealed a right upper lobe infiltrate. The oxygen saturation was 98% while on room air. Laboratory tests, including percentage of lymphocytes and total count of peripheral blood, hepatitis B virus and hepatitis C virus serological markers, and human immunodeficiency virus status, didn't reveal any form of immunosuppression. She did not suffer from diabetes mellitus or peptic ulcer disease. Symptoms persisted despite antibiotics (macrolide, penicillin-cephalosporin), inhaled corticosteroids, and long-acting ␤2 agonist treatment.A high-resolution computed tomography showed patchy subpleural infiltrates with a halo sign in the right lung (Fig. 1). Enlarged mediastinal lymph nodes, right pleural effusion, and two cysts in the liver were also detected. Bronchoscopy documented a nodular submucosal infiltration involving the distal trachea and proximal right bronchial system.Mucosal biopsies from the right main bronchus showed only eosinophil infiltration and necrosis. There were no organisms, granulomas, or evidence of neoplasm. Subsequently a surgical lung biopsy was taken from the middle right lobe. The histologic findings were similar to those of the transbronchial biopsy: eosinophil infiltration and necrosis with no organism identified. Skin biopsy from subcutaneous nodules, performed 1 day before death, showed eosinophilic panniculitis, in which scattered hyphal elements were present.Autopsy report. The macroscopic examination revealed necrotic small white-yellow opacities (3 to 4 mm in diameter) in the pericardium, parietal pleura of the right hemithorax, visceral surface of the right lung, liver, spleen, kidneys, adrenal glands, pancreas, uterus and peritoneum; the stomach presented fungating necrotic mucosal lesions. Small yellowish nonulcerated nod...

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Entomophthoromycosis Caused by Conidiobolus coronatus: Clinicomycological Study Of a Case

Cited by 15 publications

References 2 publications

Zygomycetes in Human Disease

Zygomycetes in Human Disease

Entomoftoromicose (zigomicose) causada por Conidiobolus coronatus em Mato Grosso (Brasil): relato de caso

Disseminated Basidiobolomycosis in an Immunocompetent Woman

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