Ento-A alleviates DSS-induced experimental colitis in mice by remolding intestinal microbiota to regulate SCFAs metabolism and the Th17 signaling pathway

Zhao, Hairong; Wang, Qian; Zhao, Jie; Wang, Dexiao; Liu, Heng; Gao, Pengfei; Shen, Yongmei; Wu, Taoqing; Wu, Xiumei; Zhao, Yu; Zhang, Chenggui

doi:10.1016/j.biopha.2023.115985

Cited by 2 publications

(1 citation statement)

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“…They affect adaptive immune cells, particularly CD4+ T cells, by modulating their activity, proliferation, differentiation, and intercellular homeostasis. SCFAs represented by butyrate inhibit Th17 activity and differentiation, while promoting Treg activity and differentiation, thereby restoring Th17/Treg immune homeostasis to alleviate IBD ( 171 – 175 ). Additionally, pentanoate promotes IL-10 expression and reduces IL-17A secretion by reprogramming T and B cell metabolism and epigenetics ( 176 ).…”

Section: Scfas In Ibdmentioning

confidence: 99%

Crosstalk between hypoxia-inducible factor-1α and short-chain fatty acids in inflammatory bowel disease: key clues toward unraveling the mystery

Xiao,

Guo,

Wang

2024

Front. Immunol.

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The human intestinal tract constitutes a complex ecosystem, made up of countless gut microbiota, metabolites, and immune cells, with hypoxia being a fundamental environmental characteristic of this ecology. Under normal physiological conditions, a delicate balance exists among these complex “residents”, with disruptions potentially leading to inflammatory bowel disease (IBD). The core pathology of IBD features a disrupted intestinal epithelial barrier, alongside evident immune and microecological disturbances. Central to these interconnected networks is hypoxia-inducible factor-1α (HIF-1α), which is a key regulator in gut cells for adapting to hypoxic conditions and maintaining gut homeostasis. Short-chain fatty acids (SCFAs), as pivotal gut metabolites, serve as vital mediators between the host and microbiota, and significantly influence intestinal ecosystem. Recent years have seen a surge in research on the roles and therapeutic potential of HIF-1α and SCFAs in IBD independently, yet reviews on HIF-1α-mediated SCFAs regulation of IBD under hypoxic conditions are scarce. This article summarizes evidence of the interplay and regulatory relationship between SCFAs and HIF-1α in IBD, pivotal for elucidating the disease’s pathogenesis and offering promising therapeutic strategies.

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Section: Scfas In Ibdmentioning

confidence: 99%