Enthalpies of solution of methylcalix[4]resorcinarene in non-aqueous solvents as a function of concentration and temperature

Enthalpies of solution of C-alkylresorcin[4]arenes in alcohols at T= 298.15 K

“…Additionally are included D sln H 1 m and S H data for C-MeRA in the same alcohols that were obtained in a previous study [17] for purposes of comparison.…”

“…Studies related to the synthesis, conformational properties and applications in (host + guest) systems of C-alkylresorcin [4]arenes and their derivatives have been reported in the literature [1,[3][4][5][6][7][8][9][10][11][12][13][14]. Although abundant information on these topics is available, the physicochemical behavior of these macrocycles in solution is still not well understood and only a few works have been published [3,11,[15][16][17][18].…”

“…In a previous study [17], we reported the molar enthalpies of solution of C-methylresorcin [4]arene (figure 1a) in three different alcohols. The results showed that solution processes for all systems are endothermic, whereas the solvation enthalpies are negative.…”

Isothermal Calorimetry: Molecular Interactions between Small Molecules in Organic Solvents

“…In practice, an ITC experiment measures accurately the heat released or adsorbed when a molecule solution is titrated into another in a given aqueous or non-aqueous solution. The large majority of ITC measurements is conducted in aqueous solutions to study protein-ligand, DNA-drug and/or protein-protein interactions [10] whereas most of the ITC investigations in organic solvents or non-aqueous/aqueous mixtures focus on the solvation or dissolution thermodynamic study of various small molecules [20][21][22][23], drugs [24], single amino acids [25][26][27], small peptides [28], metal ions [29], etc. It is worth noting also some complexation studies for copper ions with β-alanine in ethanol [30], 15-crown-5 ether with Na + in water-ethanol [31], 18-crown-6 with triglycine in water-acetone and water-dimethyl sulfoxide [32], β-cyclodextrin with benzoic acid in water-ethanol [32], fluorescein isothiocyanate with polymers in water-methanol [33], and the association analysis of urea-based supramolecular polymers in different solvents [34].…”

Enthalpies of Solution of C-Alkylresorcin[4]arenes in Water and Acetonitrile: Hydrophilic and Hydrophobic Effects

“…While some physicochemical properties of C -ARAs have been reported, − rather little is known about their enthalpies of solution (Δ sln H ) in either aqueous or nonaqueous solvents. , Such properties are not only of intrinsic interest but can also provide fundamental insight into the behavior of C -ARAs in solution and, by analogy, of other classes of macrocyclic compounds. However, apart from the previous work by our group, , to the best of our knowledge there are no thermodynamic data on related systems from which worthwhile conclusions can be drawn at the present time.…”