Due to large-scale digitization of data and information in various application domains, the evolution of ubiquitous computing platforms and the growth and usage of the Internet, industries are moving towards a new era of technology. With this revolution, the IT infrastructure of industries is rapidly undergoing a continuous change. However, the insecure communication channel; intelligent adversaries in and out of the scene; and loopholes in the software and system development add complexity in deployment of the IT infrastructure in place. In addition, the heterogeneous service level requirements from the customers, service providers, users, along with implementation policies in industries add complexity to this problem. Hence, it is necessary to assess the risk associated with the deployment of the IT infrastructure in industries to ensure the security of the assets involved. In this chapter, we present an efficient risk assessment mechanism in IT infrastructure deployment in industries, which ensures a strong security perimeter over the underlying organizational resources.