Enteroviruses in Spain over the decade 1998–2007: Virological and epidemiological studies

Trallero, Gloria; Avellón, Ana; Otero, Almudena; Miguel, Teresa de; Pérez, C.; Rabella, N; Rubio, G; Echevarrı́a, Juan E.; Cabrerizo, María

doi:10.1016/j.jcv.2009.11.013

Cited by 83 publications

(102 citation statements)

References 42 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sequence analysis of the amplified product displayed that the three EV belonged to the EV-B species, and were assigned to E-9. These findings are consistent with other reports, which described that E-9 is among the most common virus typed in the majority of EV CNS infection cases observed in patients under 15-years-old [17,33,57]. Echovirus-9 was already detected several times over a 12-year period in Tunisia [3].…”

Section: Discussionsupporting

confidence: 93%

Enteroviral Central Nervous System Infections in Children of the Region of Monastir, Tunisia: Diagnosis, Laboratory Findings of Cerebrospinal Fluid and Clinical Manifestations

et al. 2012

View full text Add to dashboard Cite

Human enteroviruses (HEV) are one of the major causes of central nervous system (CNS) infections in pediatrics. A prospective study was conducted to assess the epidemiological, clinical, and laboratory characteristics of enterovirus (EV) infections of the CNS in children under 15-years-old, suspected of having viral CNS infections and admitted to the Pediatric Department of Monastir University Hospital, Tunisia. Enteroviral RNA was detected by 5 0 NCR nested RT-PCR assay in 33 % (20 out of 60) of cerebrospinal fluid specimens, whereas only six samples (10 %) were EV positive in cell culture. EV-positive patients were clustered according to their clinical manifestations, predominantly diagnosed as aseptic meningitis (65 %) and meningoencephalitis (20 %). Fever, headache, vomiting, and neck stiffness were the most pronounced symptoms. Pleocytosis with the predominance of lymphocytes was observed in 60 % of EV positive specimens. Although patients suffering from EV infections were encountered throughout the year, most occurred during spring and summer months. Using VP1-2A nested RT-PCR and sequence analysis, three of the 20 positive HEV were identified as Echovirus (E)-9. This is the first report of a cluster of aseptic meningitis cases caused by E-9 in Monastir.

show abstract

Section: Discussionsupporting

confidence: 93%

Enteroviral Central Nervous System Infections in Children of the Region of Monastir, Tunisia: Diagnosis, Laboratory Findings of Cerebrospinal Fluid and Clinical Manifestations

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The detected non-polio serotypes included the ones which have been frequent in previous studies from Finland, Norway and Spain, [14][15][16] indicating that certain CAV serotypes are predominating. However, no CBV4, CBV5 and CAV9 strains, the strongest candidates to be diabetogenic serotypes [17][18] were detected, even though neutralizing antibodies against these viruses were present in most of the mothers (Fig.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 66%

Enterovirus infections in young infants: Are children still protected by maternal antibodies?

Salur¹,

Oikarinen²,

Tauriainen³

et al. 2011

Human Vaccines

View full text Add to dashboard Cite

“…Coxsackievirus B infections are associated with severe neurological manifestations and are involved in acute myocarditis and fatal neonatal infections (24,25). CVB5 is frequent in virus isolation records, as it consistently appears in the top five commonly identified EV types in the United States and France (13,14) and has exhibited the highest annual prevalence in a number of countries (26,27). Acute meningitis is the typical clinical presentation in CVB5 outbreaks, but the virus was recently involved in an outbreak of neurological hand, foot, and mouth disease in China (28).…”

mentioning

confidence: 99%

Phylogenetic Patterns of Human Coxsackievirus B5 Arise from Population Dynamics between Two Genogroups and Reveal Evolutionary Factors of Molecular Adaptation and Transmission

Henquell

Mirand

Richter

et al. 2013

J Virol

View full text Add to dashboard Cite

The aim of this study was to gain insights into the tempo and mode of the evolutionary processes that sustain genetic diversity in coxsackievirus B5 (CVB5) and into the interplay with virus transmission. We estimated phylodynamic patterns with a large sample of virus strains collected in Europe by Bayesian statistical methods, reconstructed the ancestral states of genealogical nodes, and tested for selection. The genealogies estimated with the structural one-dimensional gene encoding the VP1 protein and nonstructural 3CD locus allowed the precise description of lineages over time and cocirculating virus populations within the two CVB5 clades, genogroups A and B. Strong negative selection shaped the evolution of both loci, but compelling phylogenetic data suggested that immune selection pressure resulted in the emergence of the two genogroups with opposed evolutionary pathways. The genogroups also differed in the temporal occurrence of the amino acid changes. The virus strains of genogroup A were characterized by sequential acquisition of nonsynonymous changes in residues exposed at the virus 5-fold axis. The genogroup B viruses were marked by selection of three changes in a different domain (VP1 C terminus) during its early emergence. These external changes resulted in a selective sweep, which was followed by an evolutionary stasis that is still ongoing after 50 years. The inferred population history of CVB5 showed an alternation of the prevailing genogroup during meningitis epidemics across Europe and is interpreted to be a consequence of partial cross-immunity.

show abstract

Enteroviruses in Spain over the decade 1998–2007: Virological and epidemiological studies

Cited by 83 publications

References 42 publications

Enteroviral Central Nervous System Infections in Children of the Region of Monastir, Tunisia: Diagnosis, Laboratory Findings of Cerebrospinal Fluid and Clinical Manifestations

Enteroviral Central Nervous System Infections in Children of the Region of Monastir, Tunisia: Diagnosis, Laboratory Findings of Cerebrospinal Fluid and Clinical Manifestations

Enterovirus infections in young infants: Are children still protected by maternal antibodies?

Phylogenetic Patterns of Human Coxsackievirus B5 Arise from Population Dynamics between Two Genogroups and Reveal Evolutionary Factors of Molecular Adaptation and Transmission

Contact Info

Product

Resources

About