Enterovirus inhibiting activities of two lupane triterpenoids and anthraquinones from senna siamea stem bark against three serotypes of echovirus

Ogbole, Omonike O.; Akinleye, Toluwanimi E.; Faleye, Temitope Oluwasegun Cephas; Ja, Aznar

doi:10.23893/1307-2080.aps.05720

Cited by 3 publications

(2 citation statements)

References 33 publications

(32 reference statements)

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“…Emodin has been shown to have potent inhibitory activities against Coxsackie virus (CVB 5 ) and respiratory syncytial virus (RSV) [16]. Another anthraquinone, physcion, isolated from Senna siamea, has been shown to possess anti-enteroviral activities [17]. Rhein (an anthraquinone) has been reported to demonstrate anti-influenza A virus activity through regulating oxidative stress and various signaling pathways like MAP-kinase (mitogen activated protein kinase) and nuclear factor kappa B (NF-B) pathways [18].…”

Section: Fig 3 Interaction Of Cassiaoccidentalin C With Sars-cov-2 mentioning

confidence: 99%

Evaluation of Phytochemicals of Cassia occidentalis L. for their Binding Affinities to SARS-CoV-2 3C-Like Protease: An in Silico Approach

Bondhon

Rana

Hasan

et al. 2020

AJRID

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Aims: Corona virus SARS-CoV-2, otherwise known as COVID-19 has created a pandemic resulting in social and financial crisis throughout the world. The virus has no known drugs or vaccines for preventive or therapeutic purposes. The objective of the present study was to screen phytochemicals from Cassia occidentalis L. in virtual screening (in silico) studies to evaluate their potential of binding to the main 3C-like protease of the virus and so stop its replication. Study Design: Molecular docking approach was used for virtual screening studies. Place and Duration of Study: University of Development Alternative between April and July 2020. Methodology: Molecular docking (blind) were done with the help of Autodock Vina. We have used the pdb file (6LU7) of the main protease of SARS-CoV-2 3C-like protease or SARS-CoV-2 3CLpro (monomeric form) to study binding of the phytochemicals. Results: Of the nine phytochemicals studied, the C-glycosidic flavonoids, cassiaoccidentalins A-C demonstrated excellent binding affinities to the protease. The compounds bound to the active site of the protease with binding energy values of -8.2 to-8.4 kcal/mol. Conclusion: The in silico studies suggest that the compounds merit actual COVID-19 inhibitory tests and have potential for anti-COVID-19 use.

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Section: Fig 3 Interaction Of Cassiaoccidentalin C With Sars-cov-2 mentioning

confidence: 99%

Evaluation of Phytochemicals of Cassia occidentalis L. for their Binding Affinities to SARS-CoV-2 3C-Like Protease: An in Silico Approach

Bondhon

Rana

Hasan

et al. 2020

AJRID

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“…The stems of Senna plant species are identified with physcion, chrysophanol, betulinic acid, lupeol, and emodin [130,131]. In other studies, Lü et al [132][133][134] [133], and 1,8,10-trihydroxyl-1-O-β-D-glucopyranosyl-3-methyl-10-C (S)-β-Dglucopyranosyl-anthrone-9 [134] from stem.…”

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confidence: 99%

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Alshehri

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over the synthetic formulation of drugs. Senna is evolving as one of the important plants which have been vastly studied for its beneficial effects. Various parts of Senna species including the root, stem, leaves, and flower are found rich in numerous phytochemicals. In vitro, in vivo, and clinical experiments established that extracts from Senna plants have diverse beneficial effects by acting as a strong antioxidant and antimicrobial agent. In this review, Senna genus is comprehensively discussed in terms of its botanical characteristics, traditional use, geographic presence, and phytochemical profile. The bioactive compound richness contributes to the biological activity of Senna plant extracts. The review emphasizes on the in vivo and in vitro antioxidant and anti-infectious properties of the Senna plant. Preclinical studies confirmed the beneficial effects of the Senna plant extracts and its bioactive components in regard to the health-promoting activities. The safety, side effects, and therapeutic limitations of the Senna plant are also discussed in this review. Additional research is necessary to utilize the phenolic compounds towards its use as an alternative to pharmacological treatments and even as an ingredient in functional foods.

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Design, Synthesis and Structural Characterization of Novel Thioanthraquinone Analogues from 1,5-Dichloroanthraquinone

Özkök

2023

Journal of the Turkish Chemical Society Section A: Chemistry

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Anthraquinone and its derivatives are considered intermediate agents with superior properties due to their activities in chemical and biological reaction. A new, economical, practical and one-step synthesis method was developed by our research team for the synthesis of amino and thioanthraquinones in previous studies (1). With this synthesis method, thioanthraquinone analogs 2(a-d) were obtained from 1,5-Dichloroanthraquinone (1) and bioactive thiols. The synthesized organic molecules were purified by column chromatography and their structures were identified with spectroscopic methods. Fluorescence analyzes of synthesized thioanthraquinone analogues were performed. It was determined that all thioanthraquinone analogues synthesized and characterized in the study showed fluorescence activity. These new analogues with fluorescence are expected to find application in drug delivery systems and sensor studies.

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Enterovirus inhibiting activities of two lupane triterpenoids and anthraquinones from senna siamea stem bark against three serotypes of echovirus

Cited by 3 publications

References 33 publications

Evaluation of Phytochemicals of Cassia occidentalis L. for their Binding Affinities to SARS-CoV-2 3C-Like Protease: An in Silico Approach

Evaluation of Phytochemicals of Cassia occidentalis L. for their Binding Affinities to SARS-CoV-2 3C-Like Protease: An in Silico Approach

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Design, Synthesis and Structural Characterization of Novel Thioanthraquinone Analogues from 1,5-Dichloroanthraquinone

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