Enterovirus detection in stool samples from Mozambican children with acute gastroenteritis

Global landscape of coxsackieviruses in human health

“…Even so, the most common gastrointestinal manifestation related to EVs, particularly CVs, is diarrhea. Worldwide, numerous studies have detected CVs from the feces of patients with acute gastroenteritis (AGE), even though many of these failed to include a matched healthy control or were unable to perform an assay to identify bacteria or the presence of viruses less commonly associated with AGE ( Pham et al, 2018 ; Machado et al, 2020 ; Bero et al, 2023 ). In order to recognize EVs as major causative agents of AGE, some studies conducted in the presence of healthy controls have found CVs as an important etiologic agent of the AGE ( Rao et al, 2013 ; Chansaenroj et al, 2017 ; Rao, 2021 ; Rao et al, 2014 ).…”

“…In these studies, the majority of gastrointestinal manifestations have been implicated most frequently to EVB, particularly CVB ( Rao et al, 2013 ; Chansaenroj et al, 2017 ). In addition to CVB, other CVs-types have also been linked to gastrointestinal symptoms, such as CVA1, CVA2, CVA4, CVA5, CVA6, CVA8, CVA9, CVA10, CVA11, CVA12, CVA13, CVA14, CVA16, CVA17, CVA19, CVA20, CVA21, CVA22, and CVA24 ( Table 1 ) ( Anon., Anon., Reports on Isolation/Detection of Viruses, 2005 ; Bero et al, 2023 ; Rao et al, 2013 ; Chansaenroj et al, 2017 ; Rao, 2021 ; Rao et al, 2014 ; Rojjanadumrongkul et al, 2020 ; Chitambar et al, 2012 ; Patil et al, 2015 ). It's also interesting to highlight that follow-up studies revealed a significant association of CVs with persistent diarrhea in children ( Rao, 2021 ; Rao et al, 2014 ).…”

Ten different viral agents infecting and co‐infecting children with acute gastroenteritis in Southern Italy: Role of known pathogens and emerging viruses during and after COVID‐19 pandemic

“…However, the role of these viruses as pathogens causing AGE is still not fully understood. 9 In the present study we determined, by Real time PCR, the prevalence of ten different viruses in a pediatric population of Southern Italy hospitalized with AGE. Besides the RVA, AdV and noroviruses, (that we called known pathogens, KP) other six lessknown viruses (that we called emerging pathogens, EP) were investigated: AstV, SaV, AiV, HPeV, SalV and EV.…”

“…EVs involvement in AGE is strongly suspected by their detection in infected patients. However, the role of these viruses as pathogens causing AGE is still not fully understood 9 …”

“…Infectious acute gastroenteritis (AGE) represents a world public health relevant problem being an important cause of children mortality in developing countries and the main cause of pediatric morbidity worldwide. [1][2][3][4][5][6][7][8][9][10] The pathogens mainly involved in the episodes of AGE are the enteric viruses, which account for about 70% of the cases and are responsible every year for millions of children infections. 1,11 Gastroenteritis is usually characterized by mild symptomatology lasting a couple of days, with symptoms including diarrhea, abdominal pain, nausea, vomiting.…”