Enterovirus 71-Induced Autoimmune Hemolytic Anemia in a Boy

Pattanakitsakul, Ploy; Sirachainan, Nongnuch; Tassaneetrithep, Boonrat; Priengprom, Thongkoon; Kijporka, Pimpun; Apiwattanakul, Nopporn

doi:10.1177/11795476221132283

Cited by 2 publications

(1 citation statement)

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“…For example: enterovirus 71 can induce autoimmune hemolytic anemia. CD4 T cells and CD8 T cells are also important in the disease process of autoimmune hemolytic anemia [118]. Follicular helper T cells (Tfh), which is the initiator of eradicable immunity, can promote autoimmune hemolytic anemia [119].…”

Section: Thαβ Immunological Pathway Related With Autoimmune Hemolytic...mentioning

confidence: 99%

<strong></strong>Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A

2024

Preprint

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Systemic lupus erythematosus (SLE) is a prevalent autoimmune condition, yet its alignment with a specific host immunological pathway remains unclear. The THαβ host immunological pathway, recognized for its defense against viruses and prions, has recently emerged as a response to DNA, RNA, and protein pathogens. SLE patients often produce anti-double strand DNA antibodies and anti-nuclear antibodies, suggesting a potential association with the THαβ host immune reaction. Throughout the course of SLE, elevated levels of type 1 interferons, type 3 interferons, interleukin-10, IgG1, and IgA1 are commonly observed. These cytokines and antibody isotypes are indicative of the THαβ host immunological pathway. Similarly, Myasthenia gravis, Grave’s disease, Graft versus host disease, autoimmune hemolytic anemia, immune thrombocytopenia, dermatomyositis, and Sjogren’s syndrome are also linked to THαβ-related type 2 hypersensitivities. Considering the potential association of these diseases with dysregulated THαβ immune responses, therapeutic strategies such as anti-interleukin-10 or anti-interferons α/β could be explored to manage these disorders effectively.

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Section: Thαβ Immunological Pathway Related With Autoimmune Hemolytic...mentioning

confidence: 99%

<strong></strong>Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A

2024

Preprint

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Whole exome sequencing identifies genetic markers of enterovirus susceptibility in East Asians

Sung,

Luxton,

Hung

et al. 2024

Front. Microbiol.

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IntroductionFollowing acute enterovirus (EV) infection, outcomes vary based on factors like the immune response, viral cell entry receptor expression levels, tissue tropism, and genetic factors of both the host and virus. While most individuals exhibit mild, self-limited symptoms, others may suffer severe complications or prolonged infections that can lead to autoimmune disorders.MethodsTo elucidate host responses to EV infection, we performed whole exome sequencing on blood samples from both infected and uninfected individuals. Our initial focus was on genes encoding EV entry receptors—PSGL-1, SCARB2, and ANAXA2 for EV-A71, and CD155 for poliovirus—and on host genes ACBD3 and PI4KΒ, crucial for EV replication.ResultsAlthough no specific genetic variants directly associated with EV infection were identified, we discovered 118 variants across 116 genes enriched in East Asian populations through multi-layered variant filtering. These variants were further analyzed for their potential impacts on organs, biological processes, and molecular pathways. Phenome-wide association studies were conducted to refine our understanding of their contributions to EV infection susceptibility.DiscussionOur findings aim to develop a predictive panel based on these 118 variants, which could help susceptible individuals during EV outbreaks, guiding targeted clinical interventions and preventative strategies.

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Enterovirus 71-Induced Autoimmune Hemolytic Anemia in a Boy

Cited by 2 publications

References 40 publications

<strong></strong>Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A

<strong></strong>Type 2 Hypersensitivity Disorders including Systemic Lupus Erythematosus, Sjogren’s Syndrome, Grave’s Disease, Myasthenia Gravis, Immune Thrombocytopenia, Autoimmune Hemolytic Anemia, Dermatomyositis, and Graft versus Host Disease Are THab Dominant A

Whole exome sequencing identifies genetic markers of enterovirus susceptibility in East Asians

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