Enterotoxigenic Bacteroides fragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p

Cao, Yingying; Wang, Zhenhua; Yan, Yuqing; Ji, Linhua; He, Jie; Xuan, Baoqin; Shen, Chaoqin; Ma, Yanru; Jiang, Shanshan; Ma, Dan; Tong, Ting; Zhang, Xinyu; Gao, Zhiqiang; Zhu, Xiaoqiang; Fang, Jing‐Yuan; Chen, Haoyan; Hong, Jie

doi:10.1053/j.gastro.2021.08.003

Cited by 135 publications

(121 citation statements)

References 52 publications

Supporting

Mentioning

112

Contrasting

Order By: Relevance

“…A recent study reported that PHF5A was the target gene of miR-149, which was downregulated in CRC. 39 This may be a reason why PHF5A expression remains high upon inhibiting HATs. These findings emphasize the important roles of PHF5A in CRC progression.…”

Section: Discussionmentioning

confidence: 99%

PHF5A promotes colorectal cancer progression by alternative splicing of TEAD2

Chang

Zhao

Wang

et al. 2021

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

PHF5A promotes colorectal cancer progression by alternative splicing of TEAD2

Chang

Zhao

Wang

et al. 2021

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

“…B. fragilis is present in the intestinal mucosal layer as early as 10 days after birth [ 179 ]. The ETBF strain increases cell proliferation and tumor-promoting inflammation to promote colorectal cancer [ 137 , 138 , 139 ]. This connection with colorectal cancer is through the ETBF association with inflammatory bowel disease, which may act as a precursor to colorectal cancer [ 180 ].…”

Section: Bacterial Involvement In Colorectal Neoplasia Progressionmentioning

confidence: 99%

Bacterial Involvement in Progression and Metastasis of Colorectal Neoplasia

Seely

Morgan

Hagenstein

et al. 2022

Cancers

View full text Add to dashboard Cite

While the gut microbiome is composed of numerous bacteria, specific bacteria within the gut may play a significant role in carcinogenesis, progression, and metastasis of colorectal carcinoma (CRC). Certain microbial species are known to be associated with specific cancers; however, the interrelationship between bacteria and metastasis is still enigmatic. Mounting evidence suggests that bacteria participate in cancer organotropism during solid tumor metastasis. A critical review of the literature was conducted to better characterize what is known about bacteria populating a distant site and whether a tumor depends upon the same microenvironment during or after metastasis. The processes of carcinogenesis, tumor growth and metastatic spread in the setting of bacterial infection were examined in detail. The literature was scrutinized to discover the role of the lymphatic and venous systems in tumor metastasis and how microbes affect these processes. Some bacteria have a potent ability to enhance epithelial–mesenchymal transition, a critical step in the metastatic cascade. Bacteria also can modify the microenvironment and the local immune profile at a metastatic site. Early targeted antibiotic therapy should be further investigated as a measure to prevent metastatic spread in the setting of bacterial infection.

show abstract

“…According to a recent report, enterotoxigenic Bacteroides fragilis stimulation promotes PHF5A-mediated RNA alternative splicing of KAT2A via the downregulation of miR-149-3p, promoting intestinal inflammation and malignancy. This process depends on METTL14-mediated m6A methylation (Cao et al, 2021).…”

Section: Phytatementioning

confidence: 99%

Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer

Huo

Zhang

Huang

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Epigenetic modifications and metabolism are two fundamental biological processes. During tumorigenesis and cancer development both epigenetic and metabolic alterations occur and are often intertwined together. Epigenetic modifications contribute to metabolic reprogramming by modifying the transcriptional regulation of metabolic enzymes, which is crucial for glucose metabolism, lipid metabolism, and amino acid metabolism. Metabolites provide substrates for epigenetic modifications, including histone modification (methylation, acetylation, and phosphorylation), DNA and RNA methylation and non-coding RNAs. Simultaneously, some metabolites can also serve as substrates for nonhistone post-translational modifications that have an impact on the development of tumors. And metabolic enzymes also regulate epigenetic modifications independent of their metabolites. In addition, metabolites produced by gut microbiota influence host metabolism. Understanding the crosstalk among metabolism, epigenetic modifications, and gene expression in cancer may help researchers explore the mechanisms of carcinogenesis and progression to metastasis, thereby provide strategies for the prevention and therapy of cancer. In this review, we summarize the progress in the understanding of the interactions between cancer metabolism and epigenetics.

show abstract

Enterotoxigenic Bacteroides fragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p

Cited by 135 publications

References 52 publications

PHF5A promotes colorectal cancer progression by alternative splicing of TEAD2

PHF5A promotes colorectal cancer progression by alternative splicing of TEAD2

Bacterial Involvement in Progression and Metastasis of Colorectal Neoplasia

Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer

Contact Info

Product

Resources

About