The small bowel is one of the most difficult parts of the gastrointestinal tract to evaluate because of its long length, complex looped configuration, and also because of its distant location. Only the proximal portion of the jejunum and the terminal ileum can be examined with the use of upper gastrointestinal endoscopy and colonoscopy. Thus, other examination tools such as small bowel follow-through, enteroclysis, capsule endoscopy and double-balloon enteroscopy are used to evaluate entire small bowel loops.Recently, double-balloon enteroscopy (DBE), a new method that allows visualization of entire small bowel, is being frequently used in clinical settings. It also enables to take biopsy specimens, therapeutic interventions and contrast radiography. In our department, we introduced enteroscopy-guided contrast radiography (ECR) of small bowel lesions by injecting water-soluble contrast medium via a side hole of the enteroscope.The aim of this prospective study was to evaluate the usefulness of ECR and to demonstrate the ECR finding of various small bowel lesions. Results: ECR demonstrated abnormal findings in 11 among the 13 patients. In the cases of tumors and bezoar, the ECR images were very helpful for the surgical planning. However, for the evaluation of inflammatory lesions, DBE showed more accurate results and ECR could not demonstrate small or shallow ulcerative lesions. Conclusion: ECR can be helpful for surgical planning or determination of treatment effect in the cases of small bowel lesions that require surgical treatment or follow-up study.