Enteropathy‐associated T‐cell lymphomas have a cytotoxic T‐cell phenotype

Bruin, Peter C. de; Connolly, C. E.; Oudejans, Joost J.; Kummer, J. Alain; Jansen, Wicher; McCarthy, Conni; Meijer, C. J. L. M.

doi:10.1046/j.1365-2559.1997.2660862.x

Cited by 62 publications

(25 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…26 Cytolytic molecules like granzyme B and perforin are reportedly expressed not only in reactive lymphocytes, but also in neoplastic cells in Hodgkin lymphomas and NHLs as well. 27,28 Granzyme B ϩ tumor cells were mainly found in extranodal T-cell lymphomas and NK cell lymphomas, localized in mucosal lymphoid tissue. 29 It was suggested that these lymphomas are the neoplastic counterparts of activated CTLs or NK cells.…”

Section: Discussionmentioning

confidence: 99%

Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?

Bladergroen

Meijer

Berge

et al. 2002

Blood

138

109

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?

Bladergroen

Meijer

Berge

et al. 2002

Blood

138

109

View full text Add to dashboard Cite

“…However, studies in malignant lymphomas demonstrated that not only reactive cytotoxic leukocytes but also the neoplastic cells in various types of malignant lymphomas expressed these cytotoxic proteins. [12][13][14] Apart from rare NK/T-cell lymphomas, 15,16 expression of granzyme B (GrB), TIA-1, and perforin was noted in 70 to 90% of noncutaneous CD30 ϩ anaplastic large cell lymphomas (ALCL) of T-or null-cell phenotype and in sporadic cases of Hodgkin's disease. [17][18][19] In primary cutaneous lymphomas, recent studies demonstrated expression of GrB and TIA-1 proteins in variable proportions of neoplastic cells in most cases of lymphomatoid papulosis and primary cutaneous CD30 ϩ ALCL, but not or rarely in CD30 Ϫ primary cutaneous large T-cell lymphomas.…”

Section: Granzyme B (Grb) and T-cell-restricted Intracellularmentioning

confidence: 99%

Expression of Cytotoxic Proteins by Neoplastic T Cells in Mycosis Fungoides Increases with Progression from Plaque Stage to Tumor Stage Disease

Vermeer

Geelen

Kummer

et al. 1999

The American Journal of Pathology

View full text Add to dashboard Cite

show abstract

“…1,3). The cells had scant amounts of faintly eosinophilic cytoplasm and large, hyperchromatic nuclei.…”

mentioning

confidence: 99%

Primary Epitheliotropic Intestinal T-cell Lymphoma in a Horse

et al. 2002

View full text Add to dashboard Cite

Abstract.A 17-year-old Quarterhorse gelding with a clinical diagnosis of protein-losing enteropathy was submitted for necropsy following a 4-5-month duration of weight loss, decreased appetite, and hypoproteinemia. Gross findings included multiple 1-2-cm diameter ulcers on the luminal surfaces of the duodenum and ileum. Histologic examination revealed individual large, round cells infiltrating much of the mucosal epithelium of the duodenum, jejunum, ileum, and colon in addition to multifocal areas of ulceration. Similar round cells infiltrated Brunner's glands and expanded the submucosa beneath the foci of ulceration. Immunohistochemical staining indicated the round cell population was of T-lymphocyte origin. Several features of this equine neoplasm bear similarities to enteropathy-associated T-cell lymphoma in humans.Alimentary lymphoma in the horse is typically characterized by patchy to diffuse mucosal to transmural intestinal thickenings and infiltration of mesenteric lymph nodes. 2,6,8 In many cases, the neoplastic lymphocytes are suspected, but not demonstrated, to be of B-cell origin, presumably originating from gut-associated lymphoid follicles, 2,8 and predominantly infiltrate the lamina propria and submucosa. Herein we report an equine intestinal lymphoma in which neoplastic cells expressed T-cell, but not B-cell, antigens and were most frequently located within mucosal epithelium.A 17-year-old Quarterhorse gelding presented to the referring veterinarian in October 1999 with a 1-2-month history of weight loss and partial anorexia, which was unresponsive to antibiotic therapy, vitamin B complex, deworming, and dental care. Following a thorough clinical workup, the clinical diagnosis was protein-losing enteropathy, most likely due to small intestinal malabsorption and gastric ulceration. Treatment consisted of dexamethasone, omeprazole, and vitamin supplementation. Although the appetite improved over the next month, the horse failed to gain weight. A second glucose absorption curve revealed 27% improvement, and gastroscopy indicated the gastric ulcers had improved. Over an additional 4 weeks, the horse was able to maintain body weight but remained thin. The horse was euthanized after collapsing in the trailer in transit to the University of Illinois College of Veterinary Medicine, Urbana, Illinois.On gross examination, the horse was emaciated, with serious atrophy of pericardial and mesenteric fat. Present within the parenchyma of the right thyroid gland was a 2-ϫ 1.5-ϫ 1-cm ovoid, gray mass, which bulged at the periphery on sectioning. The abdominal cavity contained approximately 15 liters of clear, watery, pale amber fluid. The thoracic cavity contained approximately 5 liters of clear, watery, pale

show abstract

Enteropathy‐associated T‐cell lymphomas have a cytotoxic T‐cell phenotype

Abstract: EATCL is a clinicopathological entity with a grim prognosis and with tumour cells representing a unique neoplastic equivalent of CTLs arrested in varying stages of activation.

Cited by 62 publications

References 10 publications

Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?

Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?

Expression of Cytotoxic Proteins by Neoplastic T Cells in Mycosis Fungoides Increases with Progression from Plaque Stage to Tumor Stage Disease

Primary Epitheliotropic Intestinal T-cell Lymphoma in a Horse

Contact Info

Product

Resources

About