Enteropathogenic Escherichia coli: Stimulating Neutrophil Migration Across a Cultured Intestinal Epithelium Without Altering Transepithelial Conductance
Sonia K. Michail,
Dan R. Halm,
Frank Abernathy
Abstract:IntroductionMigration of neutrophils across the intestinal epithelium is the hallmark of inflammatory conditions of the bowel. In cultured intestinal epithelial monolayer models, neutrophils can be induced to migrate along a chemotactic gradient such as n‐formyl‐methionyl‐leucyl‐phenylalanine (fMLP). Physical passage of the neutrophils across the epithelium could disrupt the tight‐junctions, possibly leading to a large increase in the transepithelial conductance (Gt). The goal of this study is to determine whe… Show more
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