Enteromorpha and polysaccharides from enteromorpha ameliorate loperamide-induced constipation in mice

Ren, Xiaoliang; Liu, Lei; Gamallat, Yaser; Zhang, Bingqiang; Xin, Yi

doi:10.1016/j.biopha.2017.11.119

Cited by 78 publications

(73 citation statements)

References 36 publications

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“…It has been shown that the body weight induced by activated carbon in constipation mice is lower than that of normal mice, which is corroborated by our study [23]. Moreover, the body weight of constipated mice induced by loperamide hydrochloride has been reported to be decreased [24]. Thus, constipation can lead to a slow increase in body weight.…”

Section: Discussionsupporting

confidence: 87%

Lactobacillus Plantarum CQPC05 Isolated from Pickled Vegetables Inhibits Constipation in Mice

Zhou

et al. 2019

Applied Sciences

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This study mainly investigated the influences of Lactobacillus plantarum CQPC05 (CQPC05) isolated from pickled vegetables on mouse constipation caused by activated carbon water. We used 16S rDNA technology to identify the microorganism, and activated carbon to establish a mouse constipation model. After the mice received L. plantarum (109 CFU/mL) by gavage, small intestine tissue sections were collected. The serum indices and small intestine-related mRNA expression were obtained. A strain of L. plantarum was identified, and named CQPC05. The body weight and activated carbon progradation rate in the mice of the CQPC05 treatment groups were significantly higher than those in the control group, and the excretion time of the first tarry stool was earlier than that of the control group. The results of serum indices indicated that serum gastrin (Gas), endothelin (ET), and acetylcholinesterase (AchE) levels in the CQPC05 treatment groups were significantly higher than those in the control group, while the somatostatin (SS) level was significantly lower. Compared to the constipation control group, the result of q-PCR demonstrated that CQPC05 could up-regulate the mRNA expression of c-Kit (stem cell factor receptor), SCF (stem cell factor), and GDNF (glial cell-derived neurotrophic factor) genes, and down-regulate the expression of TRPV1 (transient receptor potential cation channel subfamily V member 1) and iNOS (inducible nitric oxide synthase). In conclusion, L. plantarum CQPC05 can effectively alleviate constipation, and has good probiotic potential and application value.

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Section: Discussionsupporting

confidence: 87%

Lactobacillus Plantarum CQPC05 Isolated from Pickled Vegetables Inhibits Constipation in Mice

Zhou

et al. 2019

Applied Sciences

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“…(B), the relative abundance level of Enterobacteriaceae in the Lop + PBS‐treated group was 11‐fold higher compared with the normal group. Enterobacteriaceae is a Gram‐negative bacterial family that is composed of several major virulent pathogens such as Salmonella , which are elevated in constipated humans and mice . Interestingly, LYC and BB12 probiotic chocolate treatments significantly reduced ( P < 0.05) and normalized the abundance level of Enterobacteriaceae.…”

Section: Resultsmentioning

confidence: 99%

“…Enterobacteriaceae is a Gram-negative bacterial family that is composed of several major virulent pathogens such as Salmonella, which are elevated in constipated humans and mice. 57,58 Interestingly, LYC and BB12 probiotic chocolate treatments significantly reduced (P < 0.05) and normalized the abundance level of Enterobacteriaceae. Owing to the ability of probiotic bacteria to produce antimicrobial factors and pathogen competitive exclusion properties, 59 these bacteria could also reduce Enterobacteriaceae.…”

Section: Effect Of Probiotic Chocolate On Constipation-related Fecal mentioning

confidence: 93%

Prophylactic use of probiotic chocolate modulates intestinal physiological functions in constipated rats

et al. 2019

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BACKGROUND This study investigated the in vivo prophylactic effect of probiotic chocolate on constipation. Rats were administered chocolate containing 2.5 × 1010 CFU g−1 of probiotics daily for 4 weeks and treated with loperamide (5 mg kg−1) daily at the fourth week of treatment. RESULTS Probiotic chocolate treatment significantly (P < 0.05) increased the intestinal motility, colon length, fecal moisture content and number of excreted fecal pellets in constipated rats. Moreover, quantitative real‐time polymerase chain reaction data and histological images also revealed that both probiotic chocolate LYC and BB12 treatments were capable of upregulating the mRNA expression levels of colonic ZO‐1, occludin and AQP8, leading to the maintenance of the defensive barrier function in the constipated rats compared with the negative controls. Interestingly, these treatments also modulated gut bacterial populations by increasing the abundance levels of Lactobacillus and Bifidobacterium, as well as reducing the abundance level of Enterobacteriaceae. CONCLUSION The present study demonstrated that probiotic chocolate LYC and BB12 could potentially be used as alternative agents for prophylactic constipation. © 2018 Society of Chemical Industry

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“…In this table, results about the prebiotic effect of green seaweed species from genus Enteromorpha [38,82,86,[113][114][115] and Ulva [115] were included. Administration of green seaweeds or seaweed-extracted polysaccharides also resulted in an increase of SCFA production, stimulating of beneficial bacteria grown such as Lactobacillus [38,86,115], Bifidobacterium [38], or Akkermansia [38] whereas inhibited the growth of potentially pathogen bacteria [81,114]. Other beneficial actions were reported such as decrease lipopolysaccharide-binding protein in female mice [38], diminished histopathological lesions of inflammatory infiltrations in distal colon [114], or modulating diabetes-related genes expression in diabetic mice [22].…”

Section: Polysaccharides From Green Seaweedsmentioning

confidence: 99%

Potential Use of Marine Seaweeds as Prebiotics: A Review

et al. 2020

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Human gut microbiota plays an important role in several metabolic processes and human diseases. Various dietary factors, including complex carbohydrates, such as polysaccharides, provide abundant nutrients and substrates for microbial metabolism in the gut, affecting the members and their functionality. Nowadays, the main sources of complex carbohydrates destined for human consumption are terrestrial plants. However, fresh water is an increasingly scarce commodity and world agricultural productivity is in a persistent decline, thus demanding the exploration of other sources of complex carbohydrates. As an interesting option, marine seaweeds show rapid growth and do not require arable land, fresh water or fertilizers. The present review offers an objective perspective of the current knowledge surrounding the impacts of seaweeds and their derived polysaccharides on the human microbiome and the profound need for more in-depth investigations into this topic. Animal experiments and in vitro colonic-simulating trials investigating the effects of seaweed ingestion on human gut microbiota are discussed.

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Enteromorpha and polysaccharides from enteromorpha ameliorate loperamide-induced constipation in mice

Cited by 78 publications

References 36 publications

Lactobacillus Plantarum CQPC05 Isolated from Pickled Vegetables Inhibits Constipation in Mice

Lactobacillus Plantarum CQPC05 Isolated from Pickled Vegetables Inhibits Constipation in Mice

Prophylactic use of probiotic chocolate modulates intestinal physiological functions in constipated rats

Potential Use of Marine Seaweeds as Prebiotics: A Review

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