Enterococcus faecalis extracts FK-23 modulates Propionibacterium acnes-induced lipogenesis in human sebocytes SZ-95 cells

Abstract

It is generally accepted that Propionibacterium acnes (P. Acne) is involved in the development of acne, while the mechanisms of sebaceous lipogenesis and its control is unclear. Enterococcus faecalis FK-23 had shown to promote an anti-inflammatory action in several animal models. In the current study, we examined whether FK-23 modulate lipogenesis in sebocytes. FK-23 stimulated lipogenesis, while inhibited them in the presence of P. Acne. FK-23 acutely inhibited acetyl-CoA carboxylase (ACC) phosphorylation levels, while stimulated them with P. Acne. FK-23 stimulated PPARγ expression and activity, while inhibited them with P. Acne as pioglitazone did. These combined evidences demonstrated that the dual action by FK-23 on lipogenesis should reflect differentiation machinery prior to PPARγ, leading to producing adequate levels of sebum.