n this issue ofJAGS, Brennen and colleagues provide one of I the first published series of cases of vancomycin-resistant enterococcus/enterococci (VRE) isolated from residents in a long-term care facility (LTCF).'.' However, VRE has been a well-described clinical problem in the setting of nosocomial infection^."^ Bacteremia caused by VRE is associated with a high mortality rate.' Moreover, patients who have VRE bacteremia appear to have a poorer prognosis than patients with blood stream infections with vancomycin-sensitive enterococci.6 In large part, this poor clinical outcome with VRE infections is a result of the unavailability of effective antibiotics against the organism and the severe clinical condition of the patient. Risk factors for VRE infection include severe underlying illness, immunosuppression, advanced age, requirement of intensive care unit treatment, prolonged hospitalization, surgical interventions, and previous exposure to antibiotics, especially vancomycin, third-generation cephalosporins, and antianaerobic Interestingly, in a recent report of 89 nonhospitalized patients infected with human immunodeficiency virus (HIV) who were receiving longterm antibiotic therapybut only one patient each receiving a cephalosporin or antianaerobic agentthere were no cases of rectal colonization with VRE."Enterococci were previously classified as streptococci of the Lancefield group D. There are two major pathogenic