Enterococcus: Antimicrobial Resistance in Enterococci Epidemiology, Treatment, and Control

Chen, Anne Y.; Zervos, Marcus J.

doi:10.1007/978-1-60327-595-8_3

Cited by 4 publications

(3 citation statements)

References 217 publications

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“…La bacteria del género Enterococcus constituye uno de los principales agentes patógenos nosocomiales en todo el mundo. Las especies E. faecalis y E. faecium son las más comunes, y causan infecciones del tracto urinario, heridas quirúrgicas y torrente sanguíneo, además de endocarditis y sepsis neonatal, entre otras (1)(2)(3). Este microorganismo tiene entre sus características principales una resistencia intrínseca a los antimicrobianos y amplia resistencia adquirida, que limitan considerablemente las opciones terapéuticas, por lo cual el control de la infección es problemático (4).…”

Section: Investigación Originalunclassified

Susceptibilidad antimicrobiana y bases genéticas de la resistencia de cepas de Enterococcus causantes de infecciones en Cuba

Pérez¹,

Capote²,

Marrero³

et al. 2011

Rev Panam Salud Publica

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Section: Investigación Originalunclassified

Susceptibilidad antimicrobiana y bases genéticas de la resistencia de cepas de Enterococcus causantes de infecciones en Cuba

Pérez¹,

Capote²,

Marrero³

et al. 2011

Rev Panam Salud Publica

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“…This change is related to the fact that E. faecium has a number of mechanisms of intrinsic resistance to cephalosporins, lincosamides, low levels of aminoglycosides, and many β-lactams (Sieńko et al, 2014). Moreover, this species is also able to acquire resistance by means of mutations or as a result of the transfer of genes located on plasmids, transposons, or due to the incorporation of integrons (Chen et al, 2009;Sieńko et al, 2014). In the standard treatment of enterococcal infections, the use of a cell wall active agent (β-lactam, glycopeptide) with an aminoglycoside results in synergistic bactericidal activity (Rodriguez-Bano et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Comparison of antibiotic resistance and virulence between biofilm-producing and non-producing clinical isolates of Enterococcus faecium

et al. 2015

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An increase in the antibiotic resistance among Enterococcus faecium strains has been observed worldwide. Moreover, this bacteria has the ability to produce several virulence factors and to form biofilm that plays an important role in human infections. This study was designed to compare the antibiotic resistance and the prevalence of genes encoding surface protein (esp), aggregation substance (as), surface adhesin (efaA), collagen adhesin (ace), gelatinase (gelE), and hialuronidase (hyl) between biofilm-producing and non-producing E. faecium strains. Therefore, ninety E. faecium clinical isolates were tested for biofilm-forming ability, and then were assigned to two groups: biofilm-positive (BIO(+), n =70) and biofilm-negative (BIO(-), n = 20). Comparison of these groups showed that BIO(+) isolates were resistant to β-lactams, whereas 10% of BIO(-) strains were susceptible to ampicillin (statistically significant difference, p = 0.007) and 5% to imipenem. Linezolid and tigecycline were the only antibiotics active against all tested isolates. Analysis of the virulence factors revealed that ace, efaA, and gelE genes occurred more frequently in BIO(-) strains (ace in 50% BIO(+) vs. 75% BIO(-); efaA 44.3% vs. 85%; gelE 2.9% vs. 15%, respectively), while hyl gene appeared more frequently in BIO(+) isolates (87.1% BIO(+) vs. 65% BIO(-)). These differences were significant (p < 0.05). We concluded that BIO(+) strains were more resistant to antibiotics than BIO(-) strains, but interestingly, BIO(-) isolates were characterized by possession of higher virulence capabilities.

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“…Iraqi Journal of Science, 2018, Vol. 59, No.4A, pp: 1811-1825 1821 out so the resistance was due to linA/linA' gene and theresistance occured for these isolates ,nucleotidyltransferase encoded by linA/linA' gene causedenzymatic inactivation of clindamycin through nucleotidylation [34][35].The rest isolates (iMLS , M and SAB resistance phenotypes) showed reduction in linA/linA'expression atconcentration below MIC value (0.1 µg/ml)because these isolates had susceptibility to clindamycin so this antibiotic supressed the expression of linA/linA' gene as shown in Figures-(6, 7)and Table-9, the reduction in linA/linA' gene expression in isolates SA40 and SA32 (iMLS) indicated that S.aureus isolates remain sensitive to clindamycin due to the abcense of inducer (macrolides) antibiotics which led to induce lincosamide resistance [36].The inhibitory effect of clindamycin is due to effecient membrane penetrating ability, resulting in a higher intracellular concentration [37].…”

Section: Mohammed and Flayyihmentioning

confidence: 98%

Study the Expression of msrA,msrB and linA/linA’ genes in Presence of Some Antibiotics in Methicillin Resistance Staphylococcus aureus

Mohammed

Flayyih

2018

ijs

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Eight isolates of methicillin resistance Staphylococcus aureus(MRSA) (SA40,SA32,SA30,SA13,SA10,SA36,SA3 and SA7) with different resistance phenotypes to macrolides , lincosamides and streptogramins Were used to detect theexpression of msrA, msrB, and linA/linA'genesby using real time polymerase chain reaction before and after treatment with antibiotics (erythromycin , clarithromycin , clindamycin and lincomycin) calibrated with triosphosphateisomerase.There highst expression of these genes was after 18 hours. It was an induction in the expression of msrA gene in isolates (SA40,SA32,SA30 and SA13) in presence of erythromycin,however,the isolates showed reduction in expression level of this gene. Expression of msrB gene had been estimated along with the using of clarithromycin and there was induction in msrB expression in isolates (SA40,SA30,SA32,SA13,SA36,SA10and SA7) while the expression level was reduced in isolate (SA3). Isolates (SA30 and SA13) showed induction of linA/linA' expression with the using of clindamycin and lincomycin respectively.

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Enterococcus: Antimicrobial Resistance in Enterococci Epidemiology, Treatment, and Control

Cited by 4 publications

References 217 publications

Susceptibilidad antimicrobiana y bases genéticas de la resistencia de cepas de Enterococcus causantes de infecciones en Cuba

Susceptibilidad antimicrobiana y bases genéticas de la resistencia de cepas de Enterococcus causantes de infecciones en Cuba

Comparison of antibiotic resistance and virulence between biofilm-producing and non-producing clinical isolates of Enterococcus faecium

Study the Expression of msrA,msrB and linA/linA’ genes in Presence of Some Antibiotics in Methicillin Resistance Staphylococcus aureus

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