The case of a 65-year-old diabetic patient who developed L5/S1 disc space infection caused by Streptococcus faecalis is reported. The patient had a history of a fall followed by transurethral resection of prostate within 2 weeks before presentation. Parenteral vancomycin administered for 6 weeks aborted the infection. The patient made good recovery. This is the first reported case of Streptococcus faecalis primary intervertebral disc space infection. The importance of prophylactic antibiotics during urosurgical operations in diabetic patients is stressed.