“…Chronic disease without active inflammation; Bowel wall thickening and enhancement on postgadolinium T1W images plus low signal intensity on T2W-FS images with possible stenosis and obstruction due to fibrosis, chronic disease with active inflammatory exacerbations; these conditions can overlap with active inflammation, require longitudinal repeated scanning (7,12,14,20,(26)(27)(28)(29)(30) (Figure 5a-b, Figure 6a MRI, extra-enteric complications of Crohn's disease or other causes of abdominal pain visualized on MRI, including liver or gallbladder disease (sclerosing cholangitis), mesenteric vascular thrombi, abdominal masses, tumors,and pancreatic abnormalities (7,14,(16)(17)(18)(19)(20)(21)26). MRE may also be used for the following clinical applications in Crohn's disease: Evaluation of the extent of small bowel disease at diagnosis, evaluation of disease burden in symptomatic patients to direct therapeutic management, evaluation of fibrostenotic disease,which may respond better to surgery than to the conservative medical therapy, confirmation of clinical remission and consideration for escalation of medical therapy if there is persistent submucosal disease despite clinical remissions, evaluation of intra-abdominal complications, including fistulae, tethering, stenosis, and abscesses, evaluation of perianal disease (7,9,11,(16)(17)(18)20,31).…”