Enteroaggregative<i>Escherichia coli</i>Strains as a Cause of Traveler's Diarrhea: A Case‐Control Study

Gascón, Joaquím; Vargas, Martha; Quintó, Llorenç; Corachán, M; Anta, M. T. Jiménez de; Vila, Jordi

doi:10.1086/517826

Cited by 63 publications

(48 citation statements)

References 18 publications

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“…Recently, in a case-control study to elucidate the role of EAggEC as a cause of traveller's diarrhoea, Gasco Ân et al [5] found that EAggEC strains were isolated signi®cantly more often from cases than from controls. Cohen et al [26] found EAggEC in 12±13% of the patients who have travelled to Central or South America, the Caribbean or Mexico.…”

Section: Discussionmentioning

confidence: 99%

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Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance

Vila

Vargas

Ruiz

et al. 2001

Journal of Medical Microbiology

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Section: Discussionmentioning

confidence: 99%

“…However, they are an important cause of acute and persistent infant diarrhoea in less-developed countries [1±4] and of traveller's diarrhoea [5,6]. Recently, they have been associated with diarrhoea in industrialised countries [7±9] and with diarrhoea in patients with human immunode®ciency virus infection [10].…”

Section: Introductionmentioning

confidence: 99%

Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance

Vila

Vargas

Ruiz

et al. 2001

Journal of Medical Microbiology

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“…6 ETEC is also the most common cause of travelers' diarrhea accounting for 10-60% of infections depending on the region visited. 7,8 Extrapolation of these figures suggests there may be 10 million cases of travelers' diarrhea caused by ETEC per year. 9 ETEC also causes disease in animals including cattle and neonatal and post-weaning pigs 10 with host specificity occurring through acquisition of colonization factors (CF) rather than emergence of animal specific lineages.…”

Section: Epidemiologymentioning

confidence: 99%

Infection strategies of enteric pathogenic Escherichia coli

Young²,

et al. 2012

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“…Few studies have compared the presence of EAEC markers in strains isolated from children with and without diarrhea in different geographic regions (9,11,24). No single study of enteric EAEC, their heterogeneous natures, and the epidemiological significance of the organism is available in Mongolia.…”

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confidence: 99%

Typical Enteroaggregative Escherichia coli Is the Most Prevalent Pathotype among E. coli Strains Causing Diarrhea in Mongolian Children

et al. 2004

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Diarrhea remains one of the main sources of morbidity and mortality in the world, and a large proportion is caused by diarrheagenic Escherichia coli. In Mongolia, the epidemiology of diarrheagenic E. coli has not been well studied. A total of 238 E. coli strains from children with sporadic diarrhea and 278 E. coli strains from healthy children were examined by PCR for 10 virulence genes: enteropathogenic E. coli (EPEC) eae, tir, and bfpA; enterotoxigenic E. coli (ETEC) lt and st; enteroinvasive E. coli (EIEC) ipaH; enterohemorragic E. coli stx1 and stx2; and enteroaggregative E. coli (EAEC) aggR and astA. EAEC strains without AggR were identified by the HEp-2 cell adherence test. The detection of EAEC, ETEC, EPEC, and EIEC was significantly associated with diarrhea. The incidence of EAEC (15.1%), defined by either a molecular or a phenotypic assay, was higher in the diarrheal group than any other category (0 to 6.0%). The incidence of AggR-positive EAEC in the diarrheal group was significantly higher than in the control group (8.0 versus 1.4%; P ‫؍‬ 0.0004), while that of AggR-negative EAEC was not (7.1 versus 4.3%). Nineteen AggR-positive EAEC strains harbored other EAEC virulence genes-aggA, 2 (5.5%); aafA, 4 (11.1%); agg-3a, 5 (13.8%); aap, 8 (22.2%); aatA, 11 (30.5%); capU, 9 (25.0%); pet, 6 (16.6%); and set, 3 (8.3%)-and showed 15 genotypes. EAEC may be an important pathogen of sporadic diarrhea in Mongolian children. Genetic analysis showed the heterogeneity of EAEC but illustrated the importance of the AggR regulon (denoting typical EAEC) as a marker for virulent EAEC strains.Diarrhea continues to be one of the most common causes of morbidity and mortality among infants and children in developing countries (5, 18). Five distinct classes of diarrheagenic Escherichia coli (DEC) are recognized as being associated with diarrheal disease. They are enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC), enteropathogenic E. coli (EPEC), enterohemorrhagic E. coli (EHEC), and enteroaggregative E. coli (EAEC); diffuse adhering E. coli (DAEC) may represent a sixth category, but this has not been clearly established (18). Each class of DEC is defined on the basis of distinct virulence characteristics, and tests for these characteristics have been developed to distinguish DEC classes from each other and from nonpathogenic E. coli strains of the normal flora (15, 34). The epidemiological significance of each E. coli category in childhood diarrhea varies with the geographical area. It has become clear that there are important regional differences in the prevalences of the different categories of DEC. The incidences of diarrheal illnesses caused by the different categories of DEC were examined mainly in Latin America, Africa, southern and Southeast Asia, and the Middle East (1,3,25,32,35,36,45). Study of the prevalences of DEC categories and their importance in childhood diarrhea has not been carried out in Mongolia. Therefore, to define the association of various categories of E. coli with diarrhea in Mongolia, w...

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EnteroaggregativeEscherichia coliStrains as a Cause of Traveler's Diarrhea: A Case‐Control Study

Cited by 63 publications

References 18 publications

Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance

Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance

Infection strategies of enteric pathogenic Escherichia coli

Typical Enteroaggregative Escherichia coli Is the Most Prevalent Pathotype among E. coli Strains Causing Diarrhea in Mongolian Children

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