Enteritis caused by Campylobacter jejuni followed by acute motor axonal neuropathy: a case report

Miljković-Selimović, Biljana; Lavrnić, Dragana; O, Morić; Ng, L.-K.; Price, Lawrence J.; Šuturkova, Ljubica; Kocić, Branislava; Babić, Tatjana; Ristic, Lidija; Apostolski, Slobodan

doi:10.1186/1752-1947-4-101

Cited by 7 publications

(4 citation statements)

References 15 publications

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“…Campylobacter jejuni is considered to be a commensal organism of chicken gut [37] and the leading causative agent of gastroenteritis in humans worldwide [38]. Although the experimental infection of chickens with C. jejuni can lead to diarrhea, chickens sometimes can develop severe paralysis resembling neuropathy [22, 39].…”

Section: Association Of C Jejuni With Gbs and Its Subtypesmentioning

confidence: 99%

Role ofCampylobacter jejuniInfection in the Pathogenesis of Guillain-Barré Syndrome: An Update

Nyati

2013

BioMed Research International

153

128

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Our current knowledge on Campylobacter jejuni infections in humans has progressively increased over the past few decades. Infection with C. jejuni is the most common cause of bacterial gastroenteritis, sometimes surpassing other infections due to Salmonella, Shigella, and Escherichia coli. Most infections are acquired due to consumption of raw or undercooked poultry, unpasteurized milk, and contaminated water. After developing the diagnostic methods to detect C. jejuni, the possibility to identify the association of its infection with new diseases has been increased. After the successful isolation of C. jejuni, reports have been published citing the occurrence of GBS following C. jejuni infection. Thus, C. jejuni is now considered as a major triggering agent of GBS. Molecular mimicry between sialylated lipooligosaccharide structures on the cell envelope of these bacteria and ganglioside epitopes on the human nerves that generates cross-reactive immune response results in autoimmune-driven nerve damage. Though C. jejuni is associated with several pathologic forms of GBS, axonal subtypes following C. jejuni infection may be more severe. Ample amount of existing data covers a large spectrum of GBS; however, the studies on C. jejuni-associated GBS are still inconclusive. Therefore, this review provides an update on the C. jejuni infections engaged in the pathogenesis of GBS.

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Section: Association Of C Jejuni With Gbs and Its Subtypesmentioning

confidence: 99%

Role ofCampylobacter jejuniInfection in the Pathogenesis of Guillain-Barré Syndrome: An Update

Nyati

2013

BioMed Research International

153

128

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“…Some species definitely cause human disease. C.jejuni is one of the most important food-borne pathogen in the world, and its infection is a leading cause of acute bacterial diarrhea in humans in many developed countries [12], [13]. Campylobacter coli , Campylobacter upsaliensis , and Campylobacter lari are also associated with human gastroenteritis [6], [7], [14].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Genomic Characterization of Campylobacter Genus Reveals Some Underlying Mechanisms for its Genomic Diversification

Zhou

Guo

et al. 2013

PLoS ONE

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Campylobacter species.are phenotypically diverse in many aspects including host habitats and pathogenicities, which demands comprehensive characterization of the entire Campylobacter genus to study their underlying genetic diversification. Up to now, 34 Campylobacter strains have been sequenced and published in public databases, providing good opportunity to systemically analyze their genomic diversities. In this study, we first conducted genomic characterization, which includes genome-wide alignments, pan-genome analysis, and phylogenetic identification, to depict the genetic diversity of Campylobacter genus. Afterward, we improved the tetranucleotide usage pattern-based naïve Bayesian classifier to identify the abnormal composition fragments (ACFs, fragments with significantly different tetranucleotide frequency profiles from its genomic tetranucleotide frequency profiles) including horizontal gene transfers (HGTs) to explore the mechanisms for the genetic diversity of this organism. Finally, we analyzed the HGTs transferred via bacteriophage transductions. To our knowledge, this study is the first to use single nucleotide polymorphism information to construct liable microevolution phylogeny of 21 Campylobacter jejuni strains. Combined with the phylogeny of all the collected Campylobacter species based on genome-wide core gene information, comprehensive phylogenetic inference of all 34 Campylobacter organisms was determined. It was found that C. jejuni harbors a high fraction of ACFs possibly through intraspecies recombination, whereas other Campylobacter members possess numerous ACFs possibly via intragenus recombination. Furthermore, some Campylobacter strains have undergone significant ancient viral integration during their evolution process. The improved method is a powerful tool for bacterial genomic analysis. Moreover, the findings would provide useful information for future research on Campylobacter genus.

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“…Symptoms of reactive arthritis usually occur around 14 days after infection (range, 3 days to 6 weeks). Some investigations revealed that the percentage of patients with confirmed C. jejuni infection who develop ReA range from 0.7%, (1.8%, 2.0%, 2.6%, 7%,) to 30% (Ristić, 2010). A population study in southern Finland found that 7% of the participants developed ReA and 1% developed reactive tendinitis, enthesopathy or bursitis (Hannu et al, 2002).…”

Section: Clinical Presentations Of Campylobacter Infectionsmentioning

confidence: 99%

Campylobacter and helicobacter in the etiology of gastrointestinal diseases

Miljković-Selimović¹,

Kocić²,

Babić³

2012

ARCH BIOL SCI BELGRA

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The order Campylobacterales comprises two genera: Campylobacter and Helicobacter, with a widespread distribution in both humans and animals. They are Gram-negative, spiral, helical and microaerophilic bacteria, with an optimal growth temperature of 37°C for H. pylori and 42°C for C. jejuni strains. While Helicobacter pylori are restricted to humans, other helicobacter species can be found in different mammals and occasionally in humans. Several Campylobacter species are recognized as human pathogens, while distinct species are pathogenic only occasionally, in children, the elderly and immunocompromised patients. Campylobacters and helicobacters are well adapted to the living conditions inside the gastrointestinal tract, where they can cause diseases as a consequence of inflammation. In addition, they are related to certain extraintestinal diseases, post-infectious sequels, malignancy and autoimmunity. Different clinical presentations of human disorders may be the consequences of the diversity in host immune response, bacterial genome, endotoxin activity as well as specific bacterial virulence factors

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Enteritis caused by Campylobacter jejuni followed by acute motor axonal neuropathy: a case report

Cited by 7 publications

References 15 publications

Role ofCampylobacter jejuniInfection in the Pathogenesis of Guillain-Barré Syndrome: An Update

Role ofCampylobacter jejuniInfection in the Pathogenesis of Guillain-Barré Syndrome: An Update

Comprehensive Genomic Characterization of Campylobacter Genus Reveals Some Underlying Mechanisms for its Genomic Diversification

Campylobacter and helicobacter in the etiology of gastrointestinal diseases

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