Entering Adolescence: Resistance to Peer Influence, Risky Behavior, and Neural Changes in Emotion Reactivity

Pfeifer, Jennifer H.; Masten, Carrie L.; Moore, W. E. C.; Oswald, Tasha M.; Mazziotta, John C.; Iacoboni, Marco; Dapretto, Mirella

doi:10.1016/j.neuron.2011.02.019

Cited by 246 publications

(229 citation statements)

References 56 publications

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“…Interestingly, we did not observe any change in TH, the enzyme associated with dopamine production, suggesting that there is no compensatory enhancement in the production of dopamine. The cortical areas that provide excitatory drive on the mesolimbic system are not fully developed at the time of the caffeine exposure (Pfeifer et al, 2011). It is possible that caffeine consumption alters the connectivity between the prefrontal cortex and the ventral tegmental area and/or the striatal areas.…”

Section: Discussionmentioning

confidence: 99%

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

O’Neill

Levis

Schreiner

et al. 2014

Neuropsychopharmacol

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Caffeine is the most commonly used psychoactive substance, and consumption by adolescents has risen markedly in recent years. We identified the effects of adolescent caffeine consumption on cocaine sensitivity and determined neurobiological changes within the nucleus accumbens (NAc) that may underlie caffeine-induced hypersensitivity to cocaine. Male Sprague-Dawley rats consumed caffeine (0.3 g/l) or water for 28 days during adolescence (postnatal day 28-55; P28-P55) or adulthood (P67-P94). Testing occurred in the absence of caffeine during adulthood (P62-82 or P101-121). Cocaine-induced and quinpirole (D 2 receptor agonist)-induced locomotion was enhanced in rats that consumed caffeine during adolescence. Adolescent consumption of caffeine also enhanced the development of a conditioned place preference at a sub-threshold dose of cocaine (7.5 mg/kg, i.p.). These behavioral changes were not observed in adults consuming caffeine for an equivalent period of time. Sucrose preferences were not altered in rats that consumed caffeine during adolescence, suggesting there are no differences in natural reward. Caffeine consumption during adolescence reduced basal dopamine levels and augmented dopamine release in the NAc in response to cocaine (5 mg/kg, i.p.). Caffeine consumption during adolescence also increased the expression of the dopamine D 2 receptor, dopamine transporter, and adenosine A 1 receptor and decreased adenosine A 2A receptor expression in the NAc. Consumption of caffeine during adulthood increased adenosine A 1 receptor expression in the NAc, but no other protein expression changes were observed. Together these findings suggest that caffeine consumption during adolescence produced changes in the NAc that are evident in adulthood and may contribute to increases in cocaine-mediated behaviors.

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Section: Discussionmentioning

confidence: 99%

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

O’Neill

Levis

Schreiner

et al. 2014

Neuropsychopharmacol

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“…These findings suggest that the amygdala may highlight the salience of social expressions during a developmental period when monitoring emotional experiences of peers is highly relevant for development. 22, 61 …”

Section: The Role Of the Amygdalamentioning

confidence: 99%

Growing pains and pleasures: how emotional learning guides development

Nelson

Lau

Jarcho

2014

Trends in Cognitive Sciences

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SUMMARY The nervous system promotes adaptive responding to myriad environmental stimuli by ascribing emotion to specific stimulus domains. This affects the salience of different stimuli, facilitates learning, and likely involves the amygdala. Recent studies suggest a strong homology between adaptive responses that result from learning and those that emerge during development. As in motivated learning, developmental studies have found the salience of different classes of stimuli (eg peers) undergoes marked fluctuation across maturation and may involve differential amygdala engagement. We suggest that variability in amygdala response to different stimulus domains may play an active and functional role in shaping emerging cortical circuits across development by highlighting the importance of particular stimulus categories during sensitive periods of development.

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“…Amongst the sparse number of such studies one found increasing activity from age 10 to 13 in the temporal pole for attending emotional versus neutral faces unconstrained (i.e. passive viewing; Pfeifer et al, 2011). Paulsen et al (2015) studied how incentives, age, and performance modulate brain activity during inhibitory control in a longitudinal design including 10-to 22-year-olds.…”

Section: Introductionmentioning

confidence: 99%

Mid-adolescent neurocognitive development of ignoring and attending emotional stimuli

Vetter

Pilhatsch

Weigelt

et al. 2015

Developmental Cognitive Neuroscience

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Appropriate reactions toward emotional stimuli depend on the distribution of prefrontal attentional resources. In mid-adolescence, prefrontal top-down control systems are less engaged, while subcortical bottom-up emotional systems are more engaged. We used functional magnetic resonance imaging to follow the neural development of attentional distribution, i.e. attending versus ignoring emotional stimuli, in adolescence. 144 healthy adolescents were studied longitudinally at age 14 and 16 while performing a perceptual discrimination task. Participants viewed two pairs of stimuli--one emotional, one abstract--and reported on one pair whether the items were the same or different, while ignoring the other pair. Hence, two experimental conditions were created: "attending emotion/ignoring abstract" and "ignoring emotion/attending abstract". Emotional valence varied between negative, positive, and neutral. Across conditions, reaction times and error rates decreased and activation in the anterior cingulate and inferior frontal gyrus increased from age 14 to 16. In contrast, subcortical regions showed no developmental effect. Activation of the anterior insula increased across ages for attending positive and ignoring negative emotions. Results suggest an ongoing development of prefrontal top-down resources elicited by emotional attention from age 14 to 16 while activity of subcortical regions representing bottom-up processing remains stable.

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Entering Adolescence: Resistance to Peer Influence, Risky Behavior, and Neural Changes in Emotion Reactivity

Cited by 246 publications

References 56 publications

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

Effects of Adolescent Caffeine Consumption on Cocaine Sensitivity

Growing pains and pleasures: how emotional learning guides development

Mid-adolescent neurocognitive development of ignoring and attending emotional stimuli

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